Guideline versus non-guideline based management of rectal cancer in octogenarians

Abstract

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Guideline- Versus Non-Guideline-Based Neoadjuvant Management of Clinical T4 Rectal Cancer

“…The NCCN and Oncology Branch of the Chinese Medical Association both recommend neoadjuvant therapy for advanced RC. Studies have also shown that hospitals with a high utilization rate of neoadjuvant therapy are associated with better survival [8][9][10]. However, in this study, only 39.55% (n = 140) of the patients received standard neoadjuvant therapy, which implies that current guidelines cannot be carried out easily for patients with clinical T4 RC.…”

“…However, previous studies have shown that receiving guideline-based neoadjuvant radiotherapy resulted in better survival benefits within 5 years. The analysis of data from two teaching hospitals in the southern part of the Netherlands between 2008 and 2015 showed that patients treated according to the guidelines had better survival 18 months after diagnosis (80 versus 56%) [10]. Eid, Y. conducted a trial in 2019 that found compliance with the relevant guidelines improved the quality of the multidisciplinary management of patients who underwent curative surgery for subperitoneal RC [9].…”

Presentation, Molecular Characteristics, Treatment, and Outcomes of Colorectal Cancer in Patients Older than 80 Years Old

“…Although somewhat higher, still only 27.5% of octogenarians with localized disease received adjuvant or neo-adjuvant chemotherapy in a series of colorectal cancer patients treated in Israel [ 14 ]. Treatment of localized rectal cancer was adherent to guidelines in only 54% of octogenarians in a retrospective series from the Netherlands [ 41 ]. Patients treated according to guidelines had an 18-month survival of 80% versus 56% for octogenarians not treated according to guidelines.…”