Guidelines for hormone replacement therapy of Asian women during the menopausal transition and thereafter

Tan, D.; Darmasetiawan, S.; Haines, Christopher J.; Huang, Kuo Yuan; Jaisamram, U.; Limpaphayom, K; Lin, Shen; Ling, YS; Nguyen, Truong-Nam; Park, K. -H.; Subramaniam, Rathan M.; Taechakraichana, Nimit; Xing, S. M.

doi:10.1080/13697130600655852

Cited by 10 publications

(7 citation statements)

References 26 publications

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“…The study also revealed that there was lack of knowledge amongst the general public regarding the menopause and its health consequences [10]. Since then, public health activities on promotion of women's health were launched and guidelines have been issued on the prescription of HRT for Asian women as there is evidence that menopausal symptoms may vary considerably when comparing Asian women with their western counterparts [11]. These actions may have helped to increase the health awareness of postmenopausal women and the usage of HRT in Hong Kong.…”

Section: Discussionmentioning

confidence: 98%

Changing epidemiology of osteoporotic hip fracture rates in Hong Kong

2007

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Section: Discussionmentioning

confidence: 98%

Changing epidemiology of osteoporotic hip fracture rates in Hong Kong

2007

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“…However, interestingly while HT is readily available to Hispanic women living in the United States, Hispanic women are least likely to use HT to treat their menopausal symptoms, opting for more natural methods such as herbs, diet, vitamins and exercise 13. In Costa Rica, the average age at onset of menopause is 50.6 years, and Costa Rican women experience menopausal symptoms comparable to their counterparts in the United States 13,14. Similar to Hispanic women living in the United States, most Costa Rican women do not often use HT to treat menopausal symptoms, but instead opt for specific herbal medicines 13,14.…”

Section: Introductionmentioning

confidence: 99%

“…In Costa Rica, the average age at onset of menopause is 50.6 years, and Costa Rican women experience menopausal symptoms comparable to their counterparts in the United States 13,14. Similar to Hispanic women living in the United States, most Costa Rican women do not often use HT to treat menopausal symptoms, but instead opt for specific herbal medicines 13,14. While there are some limited ethnobotanical data are available for these specific herbal therapies used by Costa Rican women, many of these plant species have never been scientifically investigated for their potential use for the management of menopausal symptoms.…”

Section: Introductionmentioning

confidence: 99%

Estrogenic effects of herbal medicines from Costa Rica used for the management of menopausal symptoms

et al. 2009

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Objective-Outcomes from the Women's Health Initiative have demonstrated adverse effects associated with hormone therapy (HT), and have prioritized the need to develop new alternative treatments for the management of menopause and osteoporosis. To this end, we have been investigating natural herbal medicines used by Costa Rican women to manage menopausal symptoms.Design-Seventeen plant species were collected and extracted in Costa Rica. To establish possible mechanisms of action, and determine their potential future use for menopause or osteoporosis, the estrogenic activities of the herbal extracts were investigated in an estrogen reporter gene ERβ-CALUX® assay in U2-OS cells, and in reporter and endogenous gene assays in MCF-7 cells.Results-Six of the plant extracts bound to the estrogen receptors. Four of the six extracts stimulated reporter gene expression in the ERβ-CALUX® assay. All six extracts modulated expression of endogenous genes in MCF-7 cells, with four extracts acting as estrogen agonists and two extracts, Pimenta dioica and Smilax domingensis, acting as partial agonist/antagonists by enhancing E2-stimulated pS2 mRNA expression, but reducing E2-stimulated PR and PTGES mRNA expression. Both P. dioica and S. domingensis induced a 2ERE-luciferase reporter gene in transient transfected MCF-7 cells, which was inhibited by the ER antagonist ICI 182780.Conclusions-This work presents a plausible mechanism of action for many of the herbal medicines used by Costa Rican women to treat menopausal symptoms. However, it further suggests that studies of safety and efficacy are needed before these herbs should be used as alternative therapies to HT.

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“…In addition, an expert panel was created in 2005 for the discussion and creation of guidelines for hormone replacement therapy (HRT) of Asian women during the menopause transition and thereafter. 6 APMF conducted a consensus meeting with participation of representatives from all 14 countries on April 10 to 13, 2008, at Ho Chi Minh City, Vietnam. The group agreed on the APMF Consensus Statement on Management of Menopause, which has been published on the Web site of the APMF.…”

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confidence: 99%

Menopause Perspectives and Treatment of Asian Women

Huang

2010

Semin Reprod Med

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This review summarizes the published literature on menopausal symptoms and concerns from the perspective of Asian menopausal women, compares and contrasts common menopausal symptoms between the Asian and the Western postmenopausal populations, and highlights considerations from the perspective of clinical practice. In contrast to menopausal symptomatology described in the Western populations, musculoskeletal symptoms and sleeplessness, rather than vasomotor symptoms, dominate the clinical presentation in menopausal Asian women; decreased sexual function, although an important issue, is not commonly brought up for discussion in the context of bothersome menopausal symptoms by Asian women. The epidemiology of the common disorders of aging, such as osteoporosis, breast cancer, and cardiovascular disease, differs between the Asian and Western populations. Awareness and the use of hormone replacement therapy (HRT) are generally low and noted to vary significantly among populations from different Asian countries. The perspectives, and the spectrum of symptom burden relating to reproductive aging in the Asian menopausal women are unique; an appreciation of these distinctions will allow for better tailoring of management paradigms to accommodate the diversified cultural, customary, and religious backgrounds and the socioeconomic disparities that exist among the various Asian populations.

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Guidelines for hormone replacement therapy of Asian women during the menopausal transition and thereafter

Cited by 10 publications

References 26 publications

Changing epidemiology of osteoporotic hip fracture rates in Hong Kong

Changing epidemiology of osteoporotic hip fracture rates in Hong Kong

Estrogenic effects of herbal medicines from Costa Rica used for the management of menopausal symptoms

Menopause Perspectives and Treatment of Asian Women

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