Guidelines for Neuropsychological Research in Multiple Sclerosis

Peyser, Janis M.; Rao, Stephen M.; LaRocca, Nicholas G.; Kaplan, Edith

doi:10.1001/archneur.1990.00530010120030

Cited by 244 publications

(104 citation statements)

References 49 publications

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“…Although a substantial proportion of respondents indicated that they received assistance with the survey, no objective way existed to confirm the veracity of responses. Furthermore, as many as 50 percent of individuals with MS experience a degree of cognitive impairment related to the disease [36][37]. The likelihood exists that the current sample included people with cognitive impairment, and cognitive impairment among nonresponders might also have affected sample composition.…”

Section: Discussionmentioning

confidence: 99%

Complementary and alternative medicine use in veterans with multiple sclerosis: Prevalence and demographic associations

Campbell

Turner

Williams

et al. 2006

JRRD

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Abstract-The present study explored complementary and alternative medicine (CAM) use in veterans with multiple sclerosis (MS). We administered self-report questionnaires to 451 veterans who received healthcare from Veterans Health Administration facilities. CAM use among veterans with MS was widespread; 37% of respondents reported current or past use. Roughly 33% of CAM users reported using multiple interventions, and 40% of respondents desired interventions that they were not already using. Logistic regression suggested that CAM use was more likely among participants with graduate-level education, poor self-reported health over the past year, and a progressive relapsing MS subtype. Participants who used traditional medical services were also more likely to use CAM, which suggests that CAM services are used in addition to, as opposed to in place of, traditional services. As others have proposed, these results suggest that care providers who work with persons with MS would be well served to understand, routinely screen for, and make use of CAM when appropriate.

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Section: Discussionmentioning

confidence: 99%

Complementary and alternative medicine use in veterans with multiple sclerosis: Prevalence and demographic associations

Campbell

Turner

Williams

et al. 2006

JRRD

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“…Fifth, when the brain is involved, the injury is usually widespread rather than focal. Finally, in both populations the incidence and nature of cognitive impairment has been debated, leading to consensus papers pertaining to cognitive disorders and recommended testing batteries (Benedict et al 2002b;Kozora et al 2004;Peyser et al 1990). The modified McDonald criteria may provide the best combination to date of sensitivity and specificity for an accurate diagnosis of MS (Polman et al 2005).…”

Section: Comparison With Msmentioning

confidence: 99%

Neuropsychological Impairment in Systemic Lupus Erythematosus: A Comparison with Multiple Sclerosis

et al. 2008

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In this manuscript, we review literature describing the neuropsychological and brain imaging characteristics of systemic lupus erythematosus (SLE) patients. The findings are compared and contrasted with multiple sclerosis (MS) studies, revealing similarities and differences of interest to clinicians and researchers. While cognitive impairment is somewhat less common in SLE than MS, the diseases share a similar cognitive profile with deficits most prominent on tests emphasizing the speed of information processing, working memory, and visual/spatial learning, and memory. In early or more mildly affected patients, diffuse white matter damage, which may not be apparent on conventional brain imaging, plays a major role in clinical presentation and cognitive testing. The causes of white matter damage are very different, however, and in later stages of the disease MS and SLE appear to give rise to different forms of cerebral pathology. MS may be characterized by increasing brain atrophy affecting especially the cortical and deep gray matter, at least after conversion to secondary progressive course. There is less evidence for neurodegenerative changes in SLE, but patients are increasingly at risk for cerebrovascular disease. We conclude by offering some suggestions for future clinical and imaging research. KeywordsSystemic lupus erythematosus; Multiple sclerosis; Cognition; Memory; Processing speed; MRI; Effect size Systemic lupus erythematosus (SLE) is a relapsing-remitting autoimmune disease with wide ranging organ involvement and clinical symptoms varying from mild and transient symptoms to death. Cognitive impairment is reported in SLE, even among those patients without documented or overt signs of central nervous system (CNS) involvement. Presumably, cognitive disorder is the result of underlying brain disease although the precise mechanisms remain to be elucidated. The prevalence and degree of cognitive impairment is also uncertain.In this article we will endeavor to evaluate the evidence for neuropsychological impairment in SLE, and to compare the findings with that of MS, another immunological disorder whose symptoms wax and wane and which affects women more than men. Unlike SLE, MS is a disease that always impacts the CNS, and the causes of cognitive disorder in MS are better understood.

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“…4 Cognitive impairment is a common clinical feature of MS at both the earlier and later stages of the disease, 5,6 with prevalence rates ranging from 43% to 70%. 7,8 MS has been shown to affect negatively various aspects of cognitive function including those associated with attention, 9,10 efficiency of information processing, 9,11 executive function, 12 processing speed, 13 new learning and memory. 8,13 Cognitive dysfunction is closely associated with functional status in MS. Rao et al 8 found that individuals with MS who were cognitively impaired participated in fewer social and vocational activities, were less likely to be employed, had greater difficulties in doing routine household tasks, and were more vulnerable to psychiatric illness than individuals with a purely physical disability.…”

Section: Introductionmentioning

confidence: 99%