Guidelines for Prevention and Treatment of Chronic Hepatitis B

Wang, Guiqiang; Duan, Zhongping

doi:10.14218/jcth.2021.00209

Cited by 58 publications

(117 citation statements)

References 202 publications

(311 reference statements)

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Section: Discussionmentioning

confidence: 99%

“…Globally, there are nearly 887000 deaths per year from HBV infection-related diseases, of which HBV-related HCC accounts for about 38% [ 32 ]. In China, the proportion of HCC caused by HBV is as high as 84% [ 32 ]. Research on the molecular mechanisms of HBV-related HCC development is still emerging, but there is still a lack of effective biomarkers for targeted therapy.…”

Section: Discussionmentioning

confidence: 99%

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Identification of Key Drug Targets and Molecular Mechanisms of Curcumae Rhizoma Acting on HBV-Related HCC: Weighted Correlation Network and Network Pharmacological Analyses

Zhao

Liu

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) has poor prognosis and high mortality rate. Curcumae Rhizoma, a classic Chinese medicinal herb, is often used to treat tumors. Methods. Active ingredients of Curcumae Rhizoma were extracted from the Traditional Chinese Medicine Database and Analysis Platform (TCMSP) database, and potential targets were predicted by the TCMSP database and Swiss Target Prediction database. The key drug targets were filtered by intersecting predicted targets, DEGs, and genes in important modules from WGCNA. Besides, the key drug targets were used to construct a network of “herb-active ingredient-target-disease” interactions and subjected to enrichment analysis and protein-protein interaction (PPI) analysis. The hub targets based on PPI analysis was evaluated by the KMplotter database. Results. Three active ingredients of Curcumae Rhizoma were collected with OB ≥ 30% and DL ≥ 0.18, including hederagenin, wenjine, and bisdemethoxycurcumin. The key drug targets were mainly enriched in cell cycle checkpoint, DNA integrity checkpoint, and peptidyl-serine modification. Besides, Curcumae Rhizoma treatment of HBV-related HCC mainly involved the p53 signaling pathway and arachidonic acid metabolism. Finally, ESR1 and PTGS2 were identified as hub targets from PPI analysis. ESR1 was found to be correlated with survival in liver cancer patients with hepatitis. Conclusion. Based on WGCNA and network pharmacological analysis, our results illustrated that Curcumae Rhizoma might work through regulating multitargets and multipathways in HBV-related HCC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Identification of Key Drug Targets and Molecular Mechanisms of Curcumae Rhizoma Acting on HBV-Related HCC: Weighted Correlation Network and Network Pharmacological Analyses

Zhao

Liu

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Antiviral therapy is the most routine intervention in the treatment of LCH in modern medicine [ 20 ]. Antiviral drugs can reduce hepatitis B (HBV) replication, prevent further necrosis of liver cells, improve liver function to varying degrees, promote the recovery of liver synthesis function, and increase serum albumin concentration.…”

Section: Treatment Of Lchmentioning

confidence: 99%

Research Progress and Treatment Status of Liver Cirrhosis with Hypoproteinemia

Wen

Chen

Wei

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Liver cirrhosis is the 14th leading cause of death in adults worldwide. The liver is an important organ for the metabolism of sugar, protein, and fat. Liver cirrhosis with hypoproteinemia (LCH) can lead to metabolic disorders of the nutrients such as sugar, protein, and fat, as well as insufficient protein intake, digestion and absorption disorders, and continuous leakage of plasma protein into the abdominal cavity. Severe hypoproteinemia leads to a poor prognosis in patients. For every 10 g/L decrease in peripheral blood albumin, the risk of secondary liver disease complications will increase by 89% and the mortality rate increased by 24%–56%. Therefore, it is necessary to take urgent measures to treat liver cirrhosis with hypoalbuminemia and effectively treat and reverse the deterioration of the disease caused by hypoalbuminemia, so as to reduce the burden of secondary liver disease. Emerging evidence suggests that protein balance disorders, auxin resistance, and hyperleptinemia are key steps in the development of cirrhosis and hypoproteinemia. This study comprehensively analyzed the common complications, pathogenic mechanisms, and treatment status of cirrhosis caused by hypoproteinemia and proposed research prospects for dealing with this increasingly serious problem.

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“…Participants were enrolled from October 2020 to January 2021. The inclusion criterion for the CHB group was a diagnosis of CHB following the 2019 guidelines for the prevention and treatment of CHB in China [19]. Exclusion criteria were the diagnoses of other viral hepatitis, autoimmune, immunode ciency, fatty liver, alcoholic liver diseases, current immunosuppressive or immunomodulatory drugs.…”

Section: Patientsmentioning

confidence: 99%

Aryl hydrocarbon receptor involved in Th17/Treg imbalance in chronic hepatitis B via the AhR–RORγt–FoxP3 axis

Zhang

Liu

Lin

et al. 2022

Preprint

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Objectives: To investigate the involvement of aryl hydrocarbon receptor (AhR) in the Th17/Treg imbalance of chronic hepatitis B (CHB) via the AhR–RORγt–FoxP3 axis.Methods: The proportions of Th17 and Treg cells in peripheral venous blood collected from 18 healthy controls (HCs) and 30 patients with CHB were determined by flow cytometry. AhR, retinoic acid-related orphan receptor gamma t (RORγt), and forkhead box protein 3 (FoxP3) mRNA levels were tested by RT-qPCR. Moreover, AhR, RORγt and FoxP3 protein levels were detected by western blot. Results: The proportions of Th17 and Treg cells were significantly higher in the CHB group than those in the HC group (p < 0.005). The Th17/Treg ratio was remarkably higher in the CHB group than that in the HC group (p < 0.001). Furthermore, AhR, RORγt, and FoxP3 mRNA levels were higher in the CHB group than those in the HC group (p ≤ 0.001). The expression levels of AhR, RORγt and FoxP3 protein were higher in the CHB group than those in the HC group. Moreover, there were positive correlations between AhR and RORγt mRNA (p < 0.001, r = 0.632) and between AhR and FoxP3 mRNA (p < 0.001, r = 0.798).Conclusion: The AhR–RORγt–FoxP3 axis may mediate Th17/Treg balance in CHB to influence disease development.

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Guidelines for Prevention and Treatment of Chronic Hepatitis B

Cited by 58 publications

References 202 publications

Identification of Key Drug Targets and Molecular Mechanisms of Curcumae Rhizoma Acting on HBV-Related HCC: Weighted Correlation Network and Network Pharmacological Analyses

Identification of Key Drug Targets and Molecular Mechanisms of Curcumae Rhizoma Acting on HBV-Related HCC: Weighted Correlation Network and Network Pharmacological Analyses

Research Progress and Treatment Status of Liver Cirrhosis with Hypoproteinemia

Aryl hydrocarbon receptor involved in Th17/Treg imbalance in chronic hepatitis B via the AhR–RORγt–FoxP3 axis

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