Guidelines for prevention of fentanyl‐induced cough

Uvelin, A.; Rakić, Goran

doi:10.1111/j.1399-6576.2009.02041.x

Cited by 11 publications

(12 citation statements)

References 10 publications

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“… 11 - 13 Cause of opioid induced cough may be sudden adduction in vocal cord muscles caused by opioid induced muscle rigidity, supraglottic obstruction by soft tissues; or histamine release from mast cells in respiratory tract. 7 , 8 Agarwal reported reduced frequency of fentanyl induced cough in patients who use bronchodilator agents. 15 This suggests that broncho constructive or allergic mediators such as histamine may be the cause of fentanyl induced cough.…”

Section: Discussionmentioning

confidence: 99%

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Pheniramine Maleate is more effective than Lidocaine on Fentanyl Induced Cough

et al. 2016

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Objective:Fentanyl is frequently used during anesthesia induction. The use of fentanyl can cause cough through different mechanisms. Here, we aimed to investigate effects of pheniramine maleate (PM), an antihistaminic agent, and compare it with lidocaine on fentanyl induced cough.Methods:This is a randomized double-blind prospective clinical study of ASA I-II, 120 patients scheduled for elective abdominal surgery. Patients were administered drugs intravenously and randomly allocated into three groups: Group C (2 ml 0.9 % normal saline), Group L (1mg/kg lidocaine), and Group F (PM 45.5 mg). 90 seconds after administration, 2µ/kg fentanyl was applied in three seconds to all patients. Severity of cough (mild: 1-2, moderate: 3-5, severe> 5), time of the cough and vital parameters were recorded 90 seconds after fentanyl injection.Results:Eight patients (25%) in Group C had fentanyl induced cough whereas three patients (7.5%) in Group L and one patient (2.5%) in Group F experienced this phenomenon. There was statistically significant difference between Group F and Group C (p<0.05); however, differences between Group L and Group C or Group F and Group L were not statistically significant (p>0.05).Conclusions:Pheniramine Maleate 45.5 mg is better that placebo and as effective as lidocaine to prevent fentanyl induced cough.

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Section: Discussionmentioning

confidence: 99%

“…Supraglottic obstruction by soft tissue, fentanyl induced histamine release and/or sudden adduction in vocal cord muscles due to opioid induced muscle rigidity may be the mechanism of opioid induced cough. 7 , 8 …”

Section: Introductionmentioning

confidence: 99%

Pheniramine Maleate is more effective than Lidocaine on Fentanyl Induced Cough

et al. 2016

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“…Various methods have been recommended to reduce the incidence of FIC. Intravenous administration of dexmedetomidine, lidocaine, ephedrine or priming dose of fentanyl, and aerosol inhalation of salbutamol, beclomethasone or sodium chromoglycate proved to be helpful [1,2,4-6]. Prolonged injection time may also be considered [3].…”

Section: Discussionmentioning

confidence: 99%

“…Intravenous administration of fentanyl, however, can elicit reflex cough with an incidence ranging from 18 to 68% [1-6]. Fentanyl-induced cough (FIC) is not regarded as a significant anesthetic problem, as it is usually transient and benign.…”

mentioning

confidence: 99%

Aspiration pneumonia caused by fentanyl-induced cough -a case report-

Lim

Lee

et al. 2013

Korean J Anesthesiol

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“…15 Smoking is generally known to make airways hypersensitive and smoking cessation improves airway hyperresponsiveness. 16 -19 Other studies have reported a reduced cough reflex in current smokers compared with non-smokers; 18,20,21 and smoking abstinence can result in airways becoming reactive.…”

Section: Cough Incidence Ormentioning

confidence: 99%

Effects of a Priming Dose of Fentanyl during Anaesthesia on the Incidence and Severity of Fentanyl-Induced Cough in Current, Former and Non-Smokers

Jung

et al. 2011

J Int Med Res

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Fentanyl is commonly used during anaesthesia and can cause fentanyl-induced cough (FIC). This study investigated whether a priming dose of fentanyl reduced FIC, and determined the factors associated with increased risk of FIC. Subjects undergoing elective surgery under general anaesthesia ( n = 800) were randomized into four groups: group 1 received 2 μg/kg fentanyl bolus; groups 2, 3 and 4 received a priming dose of fentanyl 0.5 μg/kg followed by 1.5 μg/kg after 1, 2 or 3 min, respectively. The incidence of FIC was 17.0%, 10.0%, 12.5% and 11.5% for groups 1, 2, 3 and 4, respectively, with no significant between-group differences in FIC incidence or severity. The mean FIC onset time was 22 s. Former smokers were 2.91 times more likely than current smokers to experience cough. A fentanyl priming dose did not reduce the incidence and severity of FIC. Former smokers were hyper-reactive to fentanyl compared with current smokers.

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Guidelines for prevention of fentanyl‐induced cough

Cited by 11 publications

References 10 publications

Pheniramine Maleate is more effective than Lidocaine on Fentanyl Induced Cough

Pheniramine Maleate is more effective than Lidocaine on Fentanyl Induced Cough

Aspiration pneumonia caused by fentanyl-induced cough -a case report-

Effects of a Priming Dose of Fentanyl during Anaesthesia on the Incidence and Severity of Fentanyl-Induced Cough in Current, Former and Non-Smokers

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