Guidelines for Seizure Prophylaxis in Adults Hospitalized with Moderate–Severe Traumatic Brain Injury: A Clinical Practice Guideline for Health Care Professionals from the Neurocritical Care Society

Frontera, Jennifer A.; Gilmore, Emily J.; Johnson, Emily L.; Olson, DaiWai; Rayi, Appaji; Tesoro, Eljim; Ullman, Jamie; Yuan, Yuhong; Zafar, Sahar F.; Rowe, Shaun

doi:10.1007/s12028-023-01907-x

Cited by 7 publications

(1 citation statement)

References 47 publications

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“…18,45 In addition, numerous guidelines and consensus statements, including those from the American Clinical Neurophysiology Society, the American Heart Association, the European Society of Intensive Care Medicine, and the Neurocritical Care Society, have emphasized the importance of EEG monitoring in the critically ill patient population to detect and treat seizures. [46][47][48][49] Although patients on ECPR are briefly mentioned in a few of these guidelines related to cardiac arrest, there are currently no universally standardized protocols for the detection of seizures in patients specifically receiving ECMO support. Gaps in knowledge currently include detailed indications and criteria for EEG monitoring across each ECMO type, optimal timing and length of EEG monitoring, and underlying mechanisms of seizures in patients on ECMO support.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Seizures and Association With Mortality in Adult Patients Undergoing ECMO

Hwang,

Akbar,

Premraj

et al. 2024

Neurology

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Background and ObjectivesExtracorporeal membrane oxygenation (ECMO) provides lifesaving support to patients with cardiopulmonary failure. Although seizures increase mortality risks among critically ill patients broadly, studies specific to adult ECMO patients have largely been limited to single-center studies. Thus, we aimed to perform a systematic review and meta-analyses of seizure prevalence, mortality, and their associations in adult ECMO patients. MethodsPubMed, EMBASE, Cochrane trial registry, Web of Science, and SCOPUS were searched on August 5, 2023. Following the Preferred Reporting Items for Systematic Reviews and Metaanalyses guidelines, we included studies of adults undergoing venovenous ECMO (VV-ECMO), venoarterial ECMO (VA-ECMO), or extracorporeal cardiopulmonary resuscitation (ECPR) that reported seizures during ECMO. The extracted data included study characteristics, patient demographics, ECMO support, EEG monitoring, and seizures, organized by ECMO types. Forest plot and meta-regression analyses were performed. Bias assessment was performed with the Egger test and Newcastle-Ottawa Scale.

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