Guidelines for the diagnosis and management of cow's milk protein allergy in infants

Vandenplas, Yvan; Brueton, M. J.; Dupont, Christophe; Hill, David; Isolauri, Erika; Koletzko, Sibylle; Oranje, Arnold P.; Staiano, Annamaria

doi:10.1136/adc.2006.110999

Cited by 345 publications

(397 citation statements)

References 36 publications

Supporting

Mentioning

335

Contrasting

Unclassified

Order By: Relevance

“…OFC being performed after 6 months of age only, physicians were asked to collect AEs and identify those that have been shown to be associated with the development of allergy during the first months of life (PAAEs) (Vandenplas et al, 2007;Host et al, 2008;Kvenshagen et al, 2008) (Figure 1). PAAEs were grouped into three categories: (i) cutaneous symptoms included atopic dermatitis, urticaria, angioedema, eczema, dry skin when associated to another symptom, rash and pruritus, (ii) digestive symptoms included upper digestive symptoms (vomiting and gastroesophageal reflux), lower digestive symptoms (acute diarrhea, colitis, abdominal pain, constipation, abdominal distension and rectal bleeding) and general symptoms associated (fainting or transient hypotonia and failure to thrive) and (iii) respiratory symptoms included wheezing, wheezing bronchitis and spastic bronchitis.…”

Section: Outcomes Measurementmentioning

confidence: 99%

A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy

et al. 2010

View full text Add to dashboard Cite

Background/Objectives: To determine the impact of a not hydrolyzed fermented infant formula containing heat-killed Bifidobacterium breve C50 and Streptococcus thermophilus 065 (HKBBST) on the incidence of allergy-like events during the first 2 years of life in children at high risk of atopy. Subjects/Methods: This multicenter, randomized, double-blind, controlled study included infants at high risk of atopy. Infants used HKBBST or a standard infant formula (SIF) since birth until 1 year of age, and were followed at 4, 12 and 24 months after birth. Skin prick tests (SPTs) for six foods and six aeroallergens were systematically performed and adverse events (AEs) were recorded. In case of potentially allergic AE (PAAE), allergy could be further tested by SPT, patch tests and quantification of specific IgEs. If cow's milk allergy (CMA) was suspected, an oral challenge could also be performed. Results: The study included 129 children, 63 were randomized to SIF, 66 to HKBBST. The use of HKBBST milk did not alter the proportion of CMA but decreased the proportion of positive SPT to cow's milk (1.7 vs 12.5%, P ¼ 0.03), and the incidence of digestive (39 vs 63%, P ¼ 0.01) and respiratory potentially allergic AEs (7 vs 21%, P ¼ 0.03) at 12 months, and that of respiratory PAAEs at 24 months (13 vs 35%, P ¼ 0.01). Conclusions: HKBBST decreased the incidence of PAAEs in children with family history of atopy, during the first months of life and after the formula was stopped. Oral tolerance to cow's milk in infants at high risk of atopy may therefore be improved using not hydrolyzed fermented formulae.

show abstract

Section: Outcomes Measurementmentioning

confidence: 99%

A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy

et al. 2010

View full text Add to dashboard Cite

show abstract

“…The diet should be balanced, providing adequate amounts of calcium and vitamin D, either by using the correct substitute foods or by supplementation (Grimshaw, 2006;Vandenplas et al, 2007). By asking parents about the level of the elimination, adherence to a therapeutic elimination diet in children has been assessed in three previous studies (Eggesbo et al, 2001;Vlieg-Boerstra et al, 2006;Allen et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Cow's milk allergy in children: adherence to a therapeutic elimination diet and reintroduction of milk into the diet

et al. 2010

View full text Add to dashboard Cite

Background/Objectives: The basic treatment for cow's milk allergy (CMA) is the elimination of all cow's milk proteins (CMP) from the diet. This study aimed at characterizing the diet of children with a diagnosis of CMA, to assess the degree of adherence to the elimination diet and to evaluate the factors associated with the adherence and age of recovery. Subjects/Methods: From a birth cohort study, food records of 267 children diagnosed with CMA were studied to define how strictly the elimination diet was adhered to. Subsequent food records were studied to assess the age at reintroduction of milk products in the child's diet. Results: The families adhered to the elimination diet of the child with extreme accuracy in 85% of the cases. Older and monosensitized children had more often small amounts of CMP in their diet, possibly because of the absence of nutritional information by a dietitian/nutritionist. Adherence to the diet was neither related to any other sociodemographic factor studied nor to the age at reintroduction of milk products into the diet. Conclusions: The therapeutic elimination diet of children diagnosed with CMA was well adhered to. Low intakes of vitamin D, calcium, and riboflavin are of concern in children who follow or have followed a cow's milk-free diet.

show abstract

“…3 In Europe, extensively hydrolysed formulas (EHF) are the first-line substitution formulas for CMA, especially recommended for infants under 6 months of age with non-anaphylactic reactions. 4,5 AABF are recommended for children with EHF allergy and, according to some authors, can be the best option for infants with suspected multiple food allergy (MFA), previous anaphylaxis or eosinophilic oesophagitis. 5,6 Regarding allergenic potential, it is now evident that EHF can induce adverse reactions in a substantial number of infants with cow's milk allergy.…”

Section: Allergy To Extensively Hydrolysed Formulasmentioning

confidence: 99%

“…3 Greater weights are less safe as they have higher antigenic potential. [3][4][5] Allergy to EHF has been reported as rare and some authors suggest intolerance rates of approximately 10% among CMA patients. 6 We report six children, attended at Hospital Dona Estefania's Immunoallergy Department, for IgE mediated CMA and hypersensitivity to EHF, from the years 2005 to 2008 (Table 1).…”

Section: Allergy To Extensively Hydrolysed Formulasmentioning

confidence: 99%

“…2 Food hypersensitivity is associated with the presence of atopic dermatitis, gastrointestinal diseases and asthma. Various authors have found a high prevalence of food sensitisation in infants with atopic dermatitis 3,4 and Aboudiab et al determined that cow's milk proteins suppression could improve the symptoms of children with asthma and cow's milk hypersensitivity. 5 In a recent review by the Cochrane Group they concluded that the use of hydrolysed formulas and other measures in infants with a high risk of atopy could reduce the risk of asthma in the first year of life.…”

Section: To the Editormentioning

confidence: 99%

See 1 more Smart Citation

Allergy to extensively hydrolysed formulas

Antunes¹,

Borrego²,

Queiroz³

et al. 2009

Allergologia et Immunopathologia

View full text Add to dashboard Cite

Guidelines for the diagnosis and management of cow's milk protein allergy in infants

Cited by 345 publications

References 36 publications

A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy

A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy

Cow's milk allergy in children: adherence to a therapeutic elimination diet and reintroduction of milk into the diet

Allergy to extensively hydrolysed formulas

Contact Info

Product

Resources

About