Guidelines for the diagnosis and treatment of knee osteoarthritis with integrative medicine based on traditional Chinese medicine

Zeng, Lingfeng; Zhou, Guanghui; Yang, Weiyi; Liu, Jun

doi:10.3389/fmed.2023.1260943

Cited by 15 publications

(10 citation statements)

References 76 publications

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“…Thus, in our case, pain and discomfort seem not to be the major cause of alarm for patients, but rather the affectation of joint elasticity. A recent study confirmed that the incidence of pain and tenderness in the case of KOA is 36.8-60.7%, this being most often accompanied by limited activity, joint deformities, bone rub feeling, and muscle atrophy [25].…”

Section: Discussionmentioning

confidence: 86%

Analysis of the Level of Adiponectin and Selected Cytokines in Patients with Knee Osteoarthritis

Ilia,

Ciordas,

Nitusca

et al. 2024

Medicina

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Background and Objectives: Knee osteoarthritis (KOA) is a degenerative disease that is continuously targeting people of different ages, but especially the elderly population, the number of which tends to increase continuously at the global level. Apart from age, excess weight can influence the evolution of the disease, with obesity being associated with a weak inflammation stage and an imbalance between pro-inflammatory and anti-inflammatory cytokines. The present work aimed to analyze specific biomarkers, namely ACRP-30, IL-10, TNF-α, and IL-6, in knee synovial fluid, and correlate them with KOA patients’ clinical data, radiographic changes, and functional and pain scores. Materials and Methods: 24 subjects with KOA and over 50 years of age participate in the present study. Synovial fluid was harvested using ultrasound guidance from the target knees of the enrolled KOA patients, and the levels of ACRP-30, IL-10, TNF-α, and IL-6 were measured using enzyme-linked immunosorbent assays (ELISA). All patients underwent a supine X-ray at the target knee and were classified using Kellgren–Lawrence (K–L) grading. The Western Ontario and McMaster University Osteoarthritis Index (WOMAC) was used to assess self-reported physical function, pain, and stiffness. Results: The obtained results highlighted a significant correlation between age and adiponectin level (p = 0.0451, r = −0.412). Also, the IL-10 values are lower in cases where the intensity of the pain is more pronounced (p = 0.0405, r = −0.421). In addition, analyzing the data by gender, it was observed that in the case of males, stiffness is more related to age (p = 0.0079, r = 0.7993), compared to women (p = 0.0203, r = 0.6223). In the case of women, the progression of the disease tends to increase more intensively the WOMAC score’s total values (p = 0.00031, r = 0.8342), compared with men (p = 0.0289, r = 7013). Regarding interleukins and BMI, significant correlations were observed only in the case of men. Conclusions: A significant correlation between age and adiponectin, and adiponectin and IL-6, suggests that advanced age may contribute to adiponectin reduction. Comparing men with women, it was observed that men’s age is more related to rigidity, and IL-6 and IL-10 are directly correlated to BMI; in addition, women seem to be more sensitive to pain and stiffness.

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Section: Discussionmentioning

confidence: 86%

Analysis of the Level of Adiponectin and Selected Cytokines in Patients with Knee Osteoarthritis

Ilia,

Ciordas,

Nitusca

et al. 2024

Medicina

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“…Notably, during stair ascent, there was a decrease in overall stair gait velocity compared to stair descent (F (1,24) =30.411, P<0.001). Additionally, step width was greater during stair descent compared to ascent (F (1, 24) =4.013, P=0.039), while no significant differences were observed for step length (F (1, 24) =0.792, P=0.318) and stride length (F (1, 24) =0.344, P=0.571) between the two directions.…”

Section: Resultsmentioning

confidence: 99%

“…In terms of stair descending, the KOA group displayed distinct stair gait characteristics compared to the control group. They exhibited shorter step length (F (1, 24) =6.002, P=0.019), wider step width (F (1, 24) =4.623, P=0.029), shorter stride length (F (1,24) =6.098, P=0.022), reduced time in single-support time (F (1, 24) =5.551, P=0.011), increased time in doublesupport time (F (1, 24) =7.875, P=0.009), prolonged total support time (F (1, 24) =9.862, P=0.003), and lower veloc-ity (F (1, 24) =18.509, P<0.001). Similarly, during stair ascending, the KOA group also demonstrated significant differences compared to the control group.…”

Section: Resultsmentioning

confidence: 99%

“…nee osteoarthritis (KOA) is a prevalent orthopedic illness that has a significant impact on the overall well-being of patients. Its primary manifestation involves the degeneration of the articular cartilage, and it is more commonly found among middle-aged and elderly individuals [1]. KOA results in a range of difficulties, including discomfort, limited joint mobility, significant medical costs, and a heightened likelihood of disability [2].…”

Section: Introductionmentioning

confidence: 99%

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Quantifying Spatial-temporal Parameters During Stair Ascent and Descent Among Knee Osteoarthritis Populations

Ebrahimipour,

Anbarian,

Sabet

et al. 2024

PTJ

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Purpose: Knee osteoarthritis (KOA) is a prevalent orthopedic condition that significantly affects patients' well-being. This study investigates the spatial and temporal gait characteristics of patients with early-stage KOA during stair ascent and descent compared to healthy individuals.Methods: A total of 12 individuals diagnosed with KOA and 12 healthy controls participated in the study. The diagnosis of KOA was based on the clinical criteria provided by the American College of Rheumatology, and disease severity was evaluated using the Kellgren-Lawrence grading scale. A thorough inclusion and exclusion protocol ensured that the participants met specific criteria. Spatial-temporal variables were measured using a 3D motion capture system during stair negotiation. A repeated-measure multivariate analysis of covariance was used for the statistical analyses (P<0.05).Results: Significant differences in spatial and temporal gait variables were observed between individuals with KOA and the healthy control group during stair descending and ascending. The KOA group exhibited shorter step length (P=0.019), wider step width (P=0.029), shorter step time in both directions (P=0.022 for descending, P=0.031 for ascending), increased time in double support phase in both directions (P=0.009 for descending, P=0.004 for ascending), prolonged total stance time in both directions (P=0.003 for descending, P=0.009 for ascending), and lower gait velocity in both directions (P<0.001). During stair ascent, the overall gait velocity decreased (P<0.001), step width increased (P=0.039), and more time was allocated to single support (P=0.009), double support (P=0.038), and total stance (P<0.001). These findings highlight the significant differences in gait variables observed in individuals with knee osteoarthritis during stair walking compared to the control group. Conclusion:These findings provide valuable insights into how KOA impacts gait adaptations during stair climbing. The results support the need for targeted treatment and rehabilitation programs to improve the quality of life for patients. These findings provide valuable insights for healthcare professionals, enabling better diagnosis, treatment, and rehabilitation for KOA patients. They also aid in developing assistive devices and assessing disease progression for improved patient care.

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“… 18 Guidelines for the diagnosis and treatment of KOA with integrative medicine based on TCM concluded that KOA can be divided into the following syndrome types: dampness‐cold obstruction syndrome, dampness–heat obstruction syndrome, qi‐blood stagnation syndrome, deficiency in liver and kidney, and qi‐blood weakness syndrome. 108 TCM is effective in the prevention and treatment of KOA, and the adverse reactions are minimal, and patient compliance is high; compared with side effects like trauma and high cost of Western medicine treatment of KOA, TCM has many unique advantages. As a traditional treatment method, Chinese medicine compounds have shown certain efficacy in alleviating knee pain, reducing inflammation, and improving knee joint function.…”

Section: Conclusion and Prospectmentioning

confidence: 99%

Knee osteoarthritis: A review of animal models and intervention of traditional Chinese medicine

Song,

Liu,

Chen

et al. 2024

Anim Models and Exp Med

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BackgroundKnee osteoarthritis (KOA) characterized by degeneration of knee cartilage and subsequent bone hyperplasia is a prevalent joint condition primarily affecting aging adults. The pathophysiology of KOA remains poorly understood, as it involves complex mechanisms that result in the same outcome. Consequently, researchers are interested in studying KOA and require appropriate animal models for basic research. Chinese herbal compounds, which consist of multiple herbs with diverse pharmacological properties, possess characteristics such as multicomponent, multipathway, and multitarget effects. The potential benefits in the treatment of KOA continue to attract attention.PurposeThis study aims to provide a comprehensive overview of the advantages, limitations, and specific considerations in selecting different species and methods for KOA animal models. This will help researchers make informed decisions when choosing an animal model.MethodsOnline academic databases (e.g., PubMed, Google Scholar, Web of Science, and CNKI) were searched using the search terms “knee osteoarthritis,” “animal models,” “traditional Chinese medicine,” and their combinations, primarily including KOA studies published from 2010 to 2023.ResultsBased on literature retrieval, this review provides a comprehensive overview of the methods of establishing KOA animal models; introduces the current status of advantages and disadvantages of various animal models, including mice, rats, rabbits, dogs, and sheep/goats; and presents the current status of methods used to establish KOA animal models.ConclusionThis study provides a review of the animal models used in recent KOA research, discusses the common modeling methods, and emphasizes the role of traditional Chinese medicine compounds in the treatment of KOA.

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Guidelines for the diagnosis and treatment of knee osteoarthritis with integrative medicine based on traditional Chinese medicine

Cited by 15 publications

References 76 publications

Analysis of the Level of Adiponectin and Selected Cytokines in Patients with Knee Osteoarthritis

Analysis of the Level of Adiponectin and Selected Cytokines in Patients with Knee Osteoarthritis

Quantifying Spatial-temporal Parameters During Stair Ascent and Descent Among Knee Osteoarthritis Populations

Knee osteoarthritis: A review of animal models and intervention of traditional Chinese medicine

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