Guidelines for the Management of Atopic Dermatitis in Children: A Systematic Review

Wang, Qi; Liu, Lamei; Su, Shaoyu

doi:10.1159/000527007

Cited by 10 publications

(4 citation statements)

References 48 publications

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“…With more than five thousand dedicated articles indexed in PubMed in the last 5 years, AD (synonym: atopic eczema) is certainly one of most studied skin diseases. The accumulated knowledge on AD exceeds the scope of the present article by far; therefore, the reader is referred to state-of-the art reviews covering general aspects [ 23 , 24 ], the newest treatment options [ 25 , 26 , 27 ], comorbidities [ 28 , 29 ], the role of skin microbiota [ 30 , 31 ] and a systematic review of expert guidelines on the diagnosis and management of AD [ 32 ] to name just a few recent examples. This section will focus only on the possible application of “omics” sciences in the improvement of the diagnostic criteria and differential diagnosis of AD versus other diseases from the SoDE.…”

Section: An Overview Of Diseases From the Spectrummentioning

confidence: 99%

Diseases from the Spectrum of Dermatitis and Eczema: Can “Omics” Sciences Help with Better Systematics and More Accurate Differential Diagnosis?

Śpiewak

2023

IJMS

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Researchers active in the field of inflammatory skin diseases from the spectrum of dermatitis and eczema are well aware of a considerable overlap in the clinical pictures and proposed sets of diagnostic criteria for these diseases, which can hardly be overcome through the clinical or epidemiological research. In effect, patients are included in studies based on vague and overlapping criteria, while heterogeneous study populations may, in turn, lead to non-representative outcomes and continued confusion. In this narrative review, a systematics of diseases from the spectrum of dermatitis and eczema is proposed based on the origins of causative factors and the pathomechanisms involved. Difficulties in differentiating between these diseases are discussed, and the extent to which advances in the “omics” sciences might help to overcome them is considered. Of all the “omics” research in this field, more than 90% of the published papers were devoted to atopic dermatitis, with a striking underrepresentation of other diseases from the spectrum of dermatitis and eczema, conditions which collectively exceed the rates of atopic dermatitis by far. A greater “omics” research effort is urgently needed to tackle other dermatitides, like allergic, irritant and protein contact dermatitis, as well as radiation, seborrheic, stasis or autoimmune dermatitis. Atopic dermatitis findings should be validated not only against healthy donors but also other dermatitides. A clinic-oriented approach is proposed for future “omics” studies in the field of dermatitis and eczema.

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Section: An Overview Of Diseases From the Spectrummentioning

confidence: 99%

Diseases from the Spectrum of Dermatitis and Eczema: Can “Omics” Sciences Help with Better Systematics and More Accurate Differential Diagnosis?

Śpiewak

2023

IJMS

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“…Based on the pathological role of skin barrier function and immune abnormalities in AD, standard treatments include topical steroids, calcineurin inhibitors, JAK inhibitors, PDE4 inhibitors, and systemic therapies such as ultraviolet irradiation, cyclosporine, biologic agents, and oral JAK inhibitors [40]. These control the pathogenesis of AD by suppressing the signaling pathway of the type 2 immune response.…”

Section: Atopic Dermatitis (Ad)mentioning

confidence: 99%

Regulatory Mechanism of the IL-33–IL-37 Axis via Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis

Tsuji,

Yamamura,

Kawamura

et al. 2023

IJMS

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Interleukin (IL)-33 and IL-37 have been identified as novel cytokines involved in various inflammatory diseases. However, their specific roles remain largely unknown. Recent studies have shown that IL-33, which triggers inflammation, and IL-37, which suppresses it, cooperatively regulate the balance between inflammation and anti-inflammation. IL-33 and IL-37 are also deeply involved in the pathogenesis of inflammatory skin diseases such as atopic dermatitis (AD) and psoriasis. Furthermore, a signaling pathway by which aryl hydrocarbon receptor (AHR), a receptor for dioxins, regulates the expression of IL-33 and IL-37 has been revealed. Here, we outline recent findings on the mechanisms regulating IL-33 and IL-37 expression in AD and psoriasis. IL-33 expression is partially dependent on mitogen-activated protein kinase (MAPK) activation, and IL-37 has a role in suppressing MAPK in human keratinocytes. Furthermore, IL-33 downregulates skin barrier function proteins including filaggrin and loricrin, thereby downregulating the expression of IL-37, which colocalizes with these proteins. This leads to an imbalance of the IL-33–IL-37 axis, involving increased IL-33 and decreased IL-37, which may be associated with the pathogenesis of AD and psoriasis. Therefore, AHR-mediated regulation of the IL-33–IL-37 axis may lead to new therapeutic strategies for the treatment of AD and psoriasis.

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“…Por lo general afectan la cara, las manos y los extensores, pero también pueden afectar el cuero cabelludo, el cuello y el tronco 6,7 . Existen varios criterios diagnósticos desarrollados desde 1980 por Hanifn and Rajka hasta la actualidad por la Academia Americana de Dermatología o por la Asociación Japones de Dermatología 4,6,16 . Los criterios diagnósticos se basan en tres elementos básicos: a) prurito, b) morfología y distribución típicas del eczema; y c) curso crónico o con recaídas 4,16 (tabla 1).…”

Section: Diagnósticounclassified

Diagnóstico y Tratamiento de la Dermatitis Atópica en Niños: Una Revisión Integral de las Estrategias Clínicas

Andrango Catota,

Gutiérrez Ramírez,

Cabrera Cabrera

et al. 2023

Tesla rev. cient.

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Introducción: La dermatitis atópica (DA) es una enfermedad inflamatoria más frecuente de la piel; que tiene un impacto sustancial en la calidad de vida de los pacientes. Sin pruebas diagnósticas claras, el cuadro clínico y la historia natural de la enfermedad y con la evaluación médica es el Gold Standartd para su diagnóstico. Desarrollo: Se realizó un artículo de revisión de los documentos de las sociedades científicas dedicadas al cuidado de la dermatitis atópica en niños, así como de revisiones sistemáticas y estudios científicos actuales por medio de los buscadores SCOPUS, WOS y Pubmed y Google Scholar tanto en español como en inglés. Aplicaciones prácticas: En los últimos años, han salido nuevos tratamientos al mercado para su uso en DA en niños. Además, se describen muchos agentes emergentes tópicos y sístemicos. que se están investigando en la actualizada Conclusiones: La dermatitis atópica es una enfermedad dermatológica común en la infancia a nivel mundial. El uso de criterios diagnósticos permite determinar el grado de afectación y la pauta de tratamiento para esta enfermedad. Para el tratamiento los corticoesteroides y tacrolimus son el pilar fundamental.

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Guidelines for the Management of Atopic Dermatitis in Children: A Systematic Review

Cited by 10 publications

References 48 publications

Diseases from the Spectrum of Dermatitis and Eczema: Can “Omics” Sciences Help with Better Systematics and More Accurate Differential Diagnosis?

Diseases from the Spectrum of Dermatitis and Eczema: Can “Omics” Sciences Help with Better Systematics and More Accurate Differential Diagnosis?

Regulatory Mechanism of the IL-33–IL-37 Axis via Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis

Diagnóstico y Tratamiento de la Dermatitis Atópica en Niños: Una Revisión Integral de las Estrategias Clínicas

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