Guidelines for the use of platelet transfusions

Estcourt, Lise J; Birchall, Janet; Allard, Shubha; Bassey, Stephen J; Hersey, Peter; Kerr, Jonathan P.; Mumford, Andrew D; Stanworth, Simon; Tinegate, Hazel

doi:10.1111/bjh.14423

Cited by 415 publications

(409 citation statements)

References 184 publications

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“…In fact, anti-D produces the most severe form of immune hemolysis in fetuses and newborns. Therefore, some guidelines such as the American Society of Clinical Oncology or the British Guidelines state that anti-D prophylaxis should be considered for RhD-negative children and for women of childbearing age [2,4]. This seems reasonable for immunocompetent patients.…”

Section: Discussionmentioning

confidence: 99%

“…Whenever possible and as outlined in most transfusion guidelines, PC should match the ABO and RhD group [2,3,4]. However, RhD-negative PC inventories are often not able to fully support RhD-negative patients who require chronic transfusion support.…”

Section: Introductionmentioning

confidence: 99%

“…On the contrary, politics regarding immunization prophylaxis in patients receiving RhD-positive PC is controversial. Some guidelines limit the prophylaxis to women of childbearing age while other institutions do not administer prophylaxis at all [4,9]. Our institution does not administer anti-D prophylaxis to patients affected by malignant hematological malignancies, or to women of childbearing age.…”

Section: Introductionmentioning

confidence: 99%

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Anti-D Alloimmunization after RhD-Positive Platelet Transfusion in RhD-Negative Women under 55 Years Diagnosed with Acute Leukemia: Results of a Retrospective Study

Villalba

Santiago

Freiria

et al. 2018

Transfus Med Hemother

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Background: Anti-D alloimmunization can occur when platelets from RhD-positive donors are transfused to RhD-negative patients, due to red blood cell residues in the platelet concentrates. Methods: Our objective was to analyze the anti-D alloimmunization rate in a selected group of women under 55 years of age diagnosed with acute leukemia over an 18-year period. We focused the analysis on RhD-negative patients who received RhD-positive platelet transfusions. Results: From January 1998 to October 2016, 382 women under 55 years were diagnosed with acute leukemia. A total of 56 patients were RhD-negative, and 48 (85.7%) received RhD-positive platelets. The median number of platelet concentrates transfused per patient was 23, and 48% of all platelet transfusions were RhD-positive. The 48 RhD-negative patients received a total of 949 RhD-positive platelet concentrates. Two patients developed anti-D: a 36-year-old woman with M3 acute myeloblastic leukemia and a 52-year-old patient with a secondary acute myeloblastic leukemia. Conclusion: We conclude that there is a need for agreement in the transfusion guidelines on the recommendation of anti-D alloimmunization prophylaxis. We suggest a possible benefit in favor of anti-D prophylaxis in childbearing women with acute leukemia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti-D Alloimmunization after RhD-Positive Platelet Transfusion in RhD-Negative Women under 55 Years Diagnosed with Acute Leukemia: Results of a Retrospective Study

Villalba

Santiago

Freiria

et al. 2018

Transfus Med Hemother

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“…The average lifespan of a platelet is approximately 7 days, and only when new platelets are made will the effect of the drug wear off 55. As there are no specific reversal agents for antiplatelets, the treatment of bleeding requires general measures for controlling hemostasis, cessation of antiplatelet treatment and reversal of co-prescribed anticoagulant 55…”

Section: Traumatic Hemorrhage: Acute Management Of Anticoagulant and mentioning

confidence: 99%

“…In vitro studies and a case report suggest that platelet dysfunction caused by aspirin is much easier to correct with platelet transfusion compared with clopidogrel 55. The efficacy of platelet transfusion may be reduced in patients taking clopidogrel, and a higher dose of platelets may be needed.…”

Section: Traumatic Hemorrhage: Acute Management Of Anticoagulant and mentioning

confidence: 99%

Antithrombotics in trauma: management strategies in the older patients

Wong¹,

Lovett²,

Curry³

et al. 2017

JBM

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The ageing population has resulted in a change in the demographics of trauma, and older adult trauma now accounts for a growing number of trauma admissions. The management of older adult trauma can be particularly challenging, and exhibits differences to that of the younger age groups affected by trauma. Frailty syndromes are closely related with falls, which are the leading cause of major trauma in older adults. Comorbid disease and antithrombotic use are more common in the older population. Physiological changes that occur with ageing can alter the expected clinical presentation of older persons after injury and their susceptibility to injury. Following major trauma, definitive control of hemorrhage remains essential for improving outcomes. In the initial assessment of an injured patient, it is important to consider whether the patient is taking anticoagulants or antiplatelets and if measures to promote hemostasis such as reversal are indicated. After hemostasis is achieved and bleeding has stopped, longer-term decisions to recommence antithrombotic agents can be challenging, especially in older people. In this review, we discuss one aspect of management for the older trauma patients in greater detail, that is, acute and longer-term management of antithrombotic therapy. As we consider the health needs of an ageing population, rise in elderly trauma and increasing use of antithrombotic therapy, the need for research in this area becomes more pressing to establish best practice and evidence-based care.

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B ernard‐ S oulier Syndrome

Almomani

Mangla

2004

Encyclopedic Dictionary of Genetics, Genomics and Proteomics

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Guidelines for the use of platelet transfusions

Cited by 415 publications

References 184 publications

Anti-D Alloimmunization after RhD-Positive Platelet Transfusion in RhD-Negative Women under 55 Years Diagnosed with Acute Leukemia: Results of a Retrospective Study

Anti-D Alloimmunization after RhD-Positive Platelet Transfusion in RhD-Negative Women under 55 Years Diagnosed with Acute Leukemia: Results of a Retrospective Study

Antithrombotics in trauma: management strategies in the older patients

B ernard‐ S oulier Syndrome

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