Guidelines for the use of antiretroviral agents in pediatric HIV infection

EVIRAPINE, USED TO PREvent mother-to-child human immunodeficiency virus (HIV) transmission, selects drug-resistant viral mutations among a large proportion of HIVinfected infants 1,2 and is associated with reduced viral suppression when nonnucleoside reverse transcriptase inhibitor (NNRTI)-based antiretroviral therapy is initiated. 3 A trial comparing nevirapine-based therapy to protease inhibitor (PI)-based therapy among nevirapine-exposed infants was terminated early when reduced viral suppression was observed in the nevirapine-based therapy group, 4 consistent with an adult study. 5 Current guidelines for nevirapine-exposed infants advise that treatment be initiated with regimens based on ritonavir-boosted lopinavir. 6 There are many limitations of continuing to use PI-based regimens in-definitely in young children. These include its unpleasant taste, which poses adherence challenges for children too Author Affiliations are listed at the end of this article.

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Association Between Efavirenz-Based Compared With Nevirapine-Based Antiretroviral Regimens and Virological Failure in HIV-Infected Children

Lowenthal¹,

Ellenberg²,

Machine³

et al. 2013

JAMA

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Guidelines for the use of antiretroviral agents in pediatric HIV infection

Cited by 86 publications

References 140 publications

Risk Factors for Opportunistic Illnesses in Children With Human Immunodeficiency Virus in the Era of Highly Active Antiretroviral Therapy

Risk Factors for Opportunistic Illnesses in Children With Human Immunodeficiency Virus in the Era of Highly Active Antiretroviral Therapy

Reuse of Nevirapine in Exposed HIV-Infected Children After Protease Inhibitor–Based Viral Suppression

Association Between Efavirenz-Based Compared With Nevirapine-Based Antiretroviral Regimens and Virological Failure in HIV-Infected Children

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