2011
DOI: 10.1016/j.jaad.2010.11.055
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Guidelines of care for the management of psoriasis and psoriatic arthritis

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Cited by 395 publications
(128 citation statements)
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References 193 publications
(209 reference statements)
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“…An international consensus report as well as the USA, Europe, and Japan guidelines describe that a short overlap period (e.g. 2–8 weeks) between CyA and biological therapy can be considered in order to reduce the risk of relapse 5, 6, 7, 8, 9. However, co‐administration of CyA and biologics is not recommended because of undesirable immune suppression 6…”
Section: Introductionmentioning
confidence: 99%
“…An international consensus report as well as the USA, Europe, and Japan guidelines describe that a short overlap period (e.g. 2–8 weeks) between CyA and biological therapy can be considered in order to reduce the risk of relapse 5, 6, 7, 8, 9. However, co‐administration of CyA and biologics is not recommended because of undesirable immune suppression 6…”
Section: Introductionmentioning
confidence: 99%
“…However, the I 2 statistic8 of placebo effects (which describes the percentage of variance that is related to between‐study differences) was estimated to be 82%, suggesting that the parameterization for study‐specific placebo effect in the landmark model may have helped to adequately control for any potential study‐related heterogeneity in the dataset. A similar approach (estimating study‐specific placebo effects) was also attempted in the longitudinal model, but the results were inconclusive due to overparameterization.…”
Section: Discussionmentioning
confidence: 99%
“…Long‐term (e.g., >10 years) methotrexate therapy can be effective for many patients with moderate‐to‐severe psoriasis 18; however, only an estimated 50–60% of patients who tolerate oral methotrexate doses of 15–20 mg/week will achieve marked improvement, leaving 40–50% of patients without an effective therapy 27. In addition, side effects of methotrexate are common, and regular safety monitoring is required 18.…”
Section: Considerations For Switching Therapymentioning
confidence: 99%
“…In addition, side effects of methotrexate are common, and regular safety monitoring is required 18. Up to 30% of patients discontinue methotrexate treatment due to adverse events including gastrointestinal intolerability, hepatotoxicity, bone marrow suppression, acute pneumonitis, and pulmonary fibrosis 27. Risk factors that can result in hepatotoxicity are coexisting hepatitis B or C, alcohol consumption, obesity, and type 2 diabetes mellitus.…”
Section: Considerations For Switching Therapymentioning
confidence: 99%
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