Guidelines of care for the management of psoriasis and psoriatic arthritis

Menter, Alan; Korman, Neil J.; Elmets, Craig A.; Feldman, Steven R.; Gelfand, Joel M.; Gordon, Kenneth B.; Gottlieb, Alice B.; Koo, John; Lebwohl, Mark; Lim, Henry W.; Voorhees, Abby S. Van; Beutner, Karl R.; Bhushan, Reva

doi:10.1016/j.jaad.2008.12.032

Cited by 433 publications

(215 citation statements)

References 77 publications

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“…Future work focusing on serial sampling and longitudinal studying of skin microbiome populations it PV patients, may provide information on its potential applicability as biomarker, Table 2. From a clinical perspective, we know that antimicrobial and antifungal agents are not successful in the treatment of psoriasis, which suggests that it is less attractive to explore 75, 76. However, since immune dysregulation is the key of psoriasis and recent investigations describe the extensive cross talk between the immune system and the microbiome, there may still be potential that should be explored 77.…”

Section: Discussionmentioning

confidence: 99%

A systematic literature review of the human skin microbiome as biomarker for dermatological drug development

Kolk

Wall

Balmforth

et al. 2018

Brit J Clinical Pharma

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AimsTo explore the potential of the skin microbiome as biomarker in six dermatological conditions: atopic dermatitis (AD), acne vulgaris (AV), psoriasis vulgaris (PV), hidradenitis suppurativa (HS), seborrhoeic dermatitis/pityriasis capitis (SD/PC) and ulcus cruris (UC).MethodsA systematic literature review was conducted according to the PRISMA guidelines. Two investigators independently reviewed the included studies and ranked the suitability microbiome implementation for early phase clinical studies in an adapted GRADE method.ResultsIn total, 841 papers were identified and after screening of titles and abstracts for eligibility we identified 42 manuscripts that could be included in the review. Eleven studies were included for AD, five for AV, 10 for PV, two for HS, four for SD and 10 for UC. For AD and AV, multiple studies report the relationship between the skin microbiome, disease severity and clinical response to treatment. This is currently lacking for the remaining conditions.ConclusionFor two indications – AD and AV – there is preliminary evidence to support implementation of the skin microbiome as biomarkers in early phase clinical trials. For PV, UC, SD and HS there is insufficient evidence from the literature. More microbiome‐directed prospective studies studying the effect of current treatments on the microbiome with special attention for patient meta‐data, sampling methods and analysis methods are needed to draw more substantial conclusions.

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Section: Discussionmentioning

confidence: 99%

A systematic literature review of the human skin microbiome as biomarker for dermatological drug development

Kolk

Wall

Balmforth

et al. 2018

Brit J Clinical Pharma

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“…It is characterized by periods of spontaneous regression of variable length. Topical and systemic therapies are recommended, according to international clinical guidelines [4,5]. Maintenance therapy is often the rule, in order to avoid relapse.…”

Section: Discussionmentioning

confidence: 99%

Palmar and plantar psoriasis and homeopathy – Case reports

Nwabudike¹

2017

Our Dermatol Online

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“…This finding is supported by various other studies. [10][11][12] Some studies show that this disease is equal or more common in female. 13 This may be a likely scenario even in our place due to limited access to health care facilities in case of female.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Epidemiological Features of Psoriasis in Patients Visiting Lumbini Medical College

Mikrani

Shrestha

2014

J Lumbini Med Coll

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ABSTRACT:Background: Psoriasis is a worldwide disease and varies in its clinical profile and epidemiology in different regions of the world. The disease is common and few epidemiological data are available in our country. Objective: The purpose of this study was to evaluate the epidemiologic and clinical features of Psoriasis in Lumbini Medical College. Methods: A retrospective investigation of a total of 240 patients visiting Out Patient Department (OPD) of Dermatology and Venereology of Lumbini Medical College with Psoriasis was done. The parameters included were age at onset of disease, age at first treatment, current age, sex, type of disease and distribution of lesions. Data and statistical analysis was done with SPSS 17.0. Results: The mean age of patients at onset of disease was 26.4 (SD = 14.3) years. M:F ratio was 1.16. Psoriasis vulgaris (PV) was the most common variety of the disease. Extensor surface of the body was most commonly involved. Conclusion: Psoriasis is a common dermatological disease accounting 2.9% of all dermatology patients in our center. PV is the most common clinical subtype. The disease is more frequent in the third decade of life and has a male predominance in our region. Treatment compliance has been found to be poor.

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Guidelines of care for the management of psoriasis and psoriatic arthritis

Cited by 433 publications

References 77 publications

A systematic literature review of the human skin microbiome as biomarker for dermatological drug development

A systematic literature review of the human skin microbiome as biomarker for dermatological drug development

Palmar and plantar psoriasis and homeopathy – Case reports

Clinical and Epidemiological Features of Psoriasis in Patients Visiting Lumbini Medical College

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