“…The guidelines were funded and/or developed by professional associations or societies (n = 5), academic institutions (n = 2), international organizations (n = 2), specialty/expert groups (n = 7), a combination of a specialty/expert body and a government agency (n = 1), a combination of a specialty/expert group and an international organization (n = 1), and a specialty/expert group and an academic body (n = 1). CAM recommendations were made in 16 guidelines [52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67] and included the following therapies: St. John's Wort (Hypercium perforatum) (n = 9), SAMe (S-adenosyl-L-methionine) (n = 4), exercise/physical activity (n = 12), yoga (n = 1), acupuncture (n = 3), specialized forms of acupuncture including electro-acupuncture, scalp acupuncture, filiform needle acupuncture, body acupuncture involving regulating mind and soothing the 'Gan', scalp electro-acupuncture (n = 1), ear (pressure) therapy/ pressing of ear points with herbal seeds (n = 1), relaxation training/therapy (n = 1), (bright) light therapy (n = 5), (guided) self-help/self-management (n = 5), bibliotherapy (n = 3), mindfulness based therapy/mindfulness based cognitive therapy (MBT/MCBT) (n = 6), acceptance and commitment therapy (ACT) (n = 2), sleep deprivation/wake therapy (n = 2), saffron (Crocus sativus) (n = 1), omega-3/ polyunsaturated fatty acids (n = 4), vitamin D (n = 1), folate/L-methylfolate (n = 3), inositol (n = 1), dehydroepiandrosterone (DHEA) (n = 1), tryptophan (n = 1), acetyl-Lcarnitine (ALC) (n = 1), lavender (Lavendula) (n = 1), and rose root (Rhodiola rosea) (n = 1). The aforementioned characteristics of these 16 guidelines are described in Table 1 and a summary of the CAM recommendations in these eligible guidelines are presented in Fig.…”