Guidelines that use the GRADE approach often fail to provide complete economic information for recommendations: A systematic survey

Riva, John J.; Bhatt, Meha; Brunarski, David; Busse, Jason W.; Martins, Carolina Castro; Xie, Feng; Brožek, Jan

doi:10.1016/j.jclinepi.2021.04.018

Cited by 9 publications

(3 citation statements)

References 31 publications

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“…Though the quality of evidence is important, we should keep in mind that clinical recommendations may consider other parameters such as balance between desirable and undesirable effects, patient values, patient preferences, and treatment cost. Therefore, it should be noted that in addition to objective criteria for deciding on a rating, GRADE also includes some subjective parameters that may be hard to evaluate [ 61 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

Medicines for Obesity: Appraisal of Clinical Studies with Grading of Recommendations, Assessment, Development, and Evaluation Tool

et al. 2023

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We evaluated the quality of evidence from phase III/IV clinical trials of drugs against obesity using the principles of Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool. Our systematic review evaluates the quality of clinical evidence from existing clinical trials and not the pharmacological efficacy of anti-obesity therapies. A literature search using select keywords in separate was performed in PubMed and ClinicalTrials.gov databases for phase III/IV clinical trials during the last ten years. Our findings indicate that the quality of existing clinical evidence from anti-obesity trials generally ranges from low to moderate. Most trials suffered from publication bias. Less frequently, trials suffered from the risk of bias mainly due to lack of blindness in the treatment. Our work indicates that additional higher-quality clinical trials are needed to gain more confidence in the estimate of the effect of currently used anti-obesity medicines, to allow more informed clinical decisions, thus reducing the risk of implementing potentially ineffective or even harmful therapeutic strategies.

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Section: Discussionmentioning

confidence: 99%

Medicines for Obesity: Appraisal of Clinical Studies with Grading of Recommendations, Assessment, Development, and Evaluation Tool

et al. 2023

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“…Although GRADE has been widely endorsed, its use may be inconsistent with GRADE guidance and there is variation across organisations in terms of how the EtD should be adopted and applied 9 , 10 . The level of supporting evidence provided in published EtDs for core criteria such as resources required and cost effectiveness 11 , and equity 12 has also been shown to vary.…”

Section: Introductionmentioning

confidence: 99%

“…research evidence 53% versus equity 2%) 16 . Further studies have indicated that the level of supporting evidence provided in published EtDs for criteria such as resources required and cost effectiveness 11 , and equity 12 has also been shown to vary. Factors contributing to this disparity were unclear.…”

Section: Introductionmentioning

confidence: 99%

Investigating how the GRADE Evidence to Decision (EtD) framework is used in Clinical Guidelines: a scoping review protocol

Murray,

Sharp,

Razidan

et al. 2023

HRB Open Res

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Introduction: The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) evidence to decision (EtD) framework provides a structured and transparent approach for clinical guideline developers to use when formulating recommendations. Understanding how stakeholders use the EtD framework will inform how best to provide future training and support. This scoping review objective is to identify the key characteristics of how the GRADE EtD framework is used and identify studies on perception of use by those involved in developing clinical guidelines. Methods: JBI methodology for scoping reviews will be followed. This scoping review will consider both peer review published literature and grey literature. This will include empirical studies on the use of EtDs (including both quantitative, qualitative, and mixed methods primary research articles) and discussion papers/ commentaries on the experience of using the EtD. It will also include a random sample of publicly available populated EtDs identified from databases and repositories of GRADE guidelines. The search strategy will aim to locate both published and unpublished documents. First, we will conduct an exploratory search of MEDLINE and Embase (Elsevier), supplemented with citation analysis of included articles. Populated EtDs will be identified through searches of databases and repositories of GRADE guidelines. Two researchers will independently screen, select, and extract identified documents. Data will be presented in tables and summarized descriptively. Conclusion: This scoping review will identify the key characteristics of how the GRADE EtD framework is currently being used in clinical guidelines. Review findings can be used to inform future guidance and requirements for using GRADE EtD, as well as training on how to consider the criteria in developing recommendations. Results will be disseminated through publications in peer – reviewed journals and conference presentations. We will present our findings to relevant stakeholders via the networks of the co-author team at a one-day workshop.

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Standardized wording to improve efficiency and clarity of GRADE EtD frameworks in health guidelines

Piggott

Baldeh

Dietl³

et al. 2022

Journal of Clinical Epidemiology

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Guidelines that use the GRADE approach often fail to provide complete economic information for recommendations: A systematic survey

Cited by 9 publications

References 31 publications

Medicines for Obesity: Appraisal of Clinical Studies with Grading of Recommendations, Assessment, Development, and Evaluation Tool

Medicines for Obesity: Appraisal of Clinical Studies with Grading of Recommendations, Assessment, Development, and Evaluation Tool

Investigating how the GRADE Evidence to Decision (EtD) framework is used in Clinical Guidelines: a scoping review protocol

Standardized wording to improve efficiency and clarity of GRADE EtD frameworks in health guidelines

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