Guillain-Barré-Syndrom nach Exposition mit Influenza

Hartung, Hans‐Peter; Keller‐Stanislawski, Brigitte; Hughes, Richard A.; Lehmann, Helmar C.

doi:10.1007/s00115-012-3479-8

Cited by 13 publications

(6 citation statements)

References 116 publications

(118 reference statements)

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“…The underlying etiology and pathophysiology of GBS are not completely understood, but it is thought to be an immune-mediated process, presumed to be initiated by infections of the respiratory or the intestinal tract [3,4,5,6,7]. A peak in incident cases occurring during late winter and early spring has been reported and might be explained by the seasonality of preceding infections triggering the development of GBS [8,9].…”

Section: Introductionmentioning

confidence: 99%

Estimation of Background Incidence Rates of Guillain-Barré Syndrome in Germany - A Retrospective Cohort Study with Electronic Healthcare Data

Hense

Schink²,

Kreisel³

et al. 2014

Neuroepidemiology

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Background: The Guillain-Barré syndrome (GBS) occurs after infections and as an adverse reaction to vaccines. No detailed information on incidence rates (IRs) in Germany is available. Methods: This retrospective cohort study estimated age- and sex-specific IRs of GBS in Germany in the years 2007-2009 based on electronic healthcare data from the German Pharmacoepidemiological Research Database (GePaRD). Two case definitions were applied. GBS cases had a main discharge diagnosis of GBS. GBS_PROCEDURE cases in addition had codes for relevant diagnostic procedures. Crude and standardized IRs (SIRs) with 95% confidence intervals were stratified by year, age group, sex, region and season. IR ratios (IRRs) for each stratification factor were calculated by multivariable Poisson regression. Results: Among 13,297,678 persons, 889 (693) incident GBS (GBS_PROCEDURE) cases were identified. Overall SIRs per 100,000 person years were 2.4 (2.2-2.5) for GBS and 1.8 (1.7-2.0) for GBS_PROCEDURE. (S)IRs increased with age, peaking in the age group 70-79 years (IR GBS: 5.5 (4.7-6.5)) and were higher in males than in females (e.g., IR GBS: IRR = 1.5 (1.3-1.7)) and in February-April, as compared to the rest of the year. No regional pattern was observed. Conclusion: (S)IRs of GBS in Germany differed by age, sex and season and were comparable to those found in other studies. Results might be used as a comparator in vaccine safety monitoring.

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Section: Introductionmentioning

confidence: 99%

Estimation of Background Incidence Rates of Guillain-Barré Syndrome in Germany - A Retrospective Cohort Study with Electronic Healthcare Data

Hense

Schink²,

Kreisel³

et al. 2014

Neuroepidemiology

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show abstract

“…The correlation between vaccination and autoimmune disease was previously suggested in diseases such as systemic sclerosis, chronic fatigue syndrome, fibromyalgia, transverse myelitis [33] systemic lupus erythematosus [44], anti-phospholipid syndrome, Guillain-Barré syndrome, Crohn's disease, macrophagic myofasciitis, vasculitis, myelitis vaccinations and etc [45][46][47][48][49][50][51]. The same association was suggested for childhood and infantile BP [19][20][21][22][23][24][25][26][27][28][29][30][31].…”

Section: Discussionmentioning

confidence: 77%

Infantile Bullous Pemphigoid Following Hepatitis B Vaccinations

Alex¹

2014

Immunome Res

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The development of infantile and childhood bullous pemphigoid following vaccination was already documented in several cases. This post-vaccination autoimmune phenomenon is part of the autoimmune/inflammatory syndrome induced by adjuvants (ASIA).A 4 months old female patient, presented with bullous skin rash, two months following her second inoculation with the hepatitis B vaccine (HBVv). In addition, during the appearance of the rash she received the second dose of hexavalent INFANRIX™-IPV/Hib vaccine (GSK), which was followed by irritability and fever. According to the clinical picture, biopsy result, direct immune fluorescent (DIF) and indirect immune fluorescent (IIF), a diagnosis of infantile bullous pemphigoid (BP) was determined. The patient was resistant to most conventional therapies.We report a case of an infantile BP, which appeared following immunization with HBVv. This case depicts a temporal association between the appearance of autoimmune diseases and vaccines. The appearance of bullous dermatoses following vaccinations was reported in 14 case reports. The physicians should be aware of the option of such link and further inquiry is warranted.

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“…Many interesting results have been obtained from the analysis of this group of vaccine-disease-vaccine associations. For example, the results from this group show that influenza vaccines and rabies vaccines have been associated with the induction of a severe adverse event, Guillain-Barré syndrome [24,25]. Guillain-Barré syndrome is a rare disorder in which a person’s own immune system damages the nerve cells, causing muscle weakness and sometimes paralysis.…”

Section: Resultsmentioning

confidence: 99%

Network-based analysis of vaccine-related associations reveals consistent knowledge with the vaccine ontology

Zhang

Tao

et al. 2013

J Biomed Sem

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BackgroundOntologies are useful in many branches of biomedical research. For instance, in the vaccine domain, the community-based Vaccine Ontology (VO) has been widely used to promote vaccine data standardization, integration, and computer-assisted reasoning. However, a major challenge in the VO has been to construct ontologies of vaccine functions, given incomplete vaccine knowledge and inconsistencies in how this knowledge is manually curated.ResultsIn this study, we show that network-based analysis of vaccine-related networks can identify underlying structural information consistent with that captured by the VO, and commonalities in the vaccine adverse events for vaccines and for diseases to produce new hypotheses about pathomechanisms involving the vaccine and the disease status. First, a vaccine-vaccine network was inferred by applying a bipartite network projection strategy to the vaccine-disease network extracted from the Semantic MEDLINE database. In total, 76 vaccines and 573 relationships were identified to construct the vaccine network. The shortest paths between all pairs of vaccines were calculated within the vaccine network. The correlation between the shortest paths of vaccine pairs and their semantic similarities in the VO was then investigated. Second, a vaccine-gene network was also constructed. In this network, 4 genes were identified as hubs interacting with at least 3 vaccines, and 4 vaccines were identified as hubs associated with at least 3 genes. These findings correlate with existing knowledge and provide new hypotheses in the fundamental interaction mechanisms involving vaccines, diseases, and genes.ConclusionsIn this study, we demonstrated that a combinatorial analysis using a literature knowledgebase, semantic technology, and ontology is able to reveal important unidentified knowledge critical to biomedical research and public health and to generate testable hypotheses for future experimental verification. As the associations from Semantic MEDLINE remain incomplete, we expect to extend this work by (1) integrating additional association databases to complement Semantic MEDLINE knowledge, (2) extending the neighbor genes of vaccine-associated genes, and (3) assigning confidence weights to different types of associations or associations from different sources.

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Guillain-Barré-Syndrom nach Exposition mit Influenza

Cited by 13 publications

References 116 publications

Estimation of Background Incidence Rates of Guillain-Barré Syndrome in Germany - A Retrospective Cohort Study with Electronic Healthcare Data

Estimation of Background Incidence Rates of Guillain-Barré Syndrome in Germany - A Retrospective Cohort Study with Electronic Healthcare Data

Infantile Bullous Pemphigoid Following Hepatitis B Vaccinations

Network-based analysis of vaccine-related associations reveals consistent knowledge with the vaccine ontology

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