Guillain–Barre Syndrome

Malek, Elia; Salameh, Johnny

doi:10.1055/s-0039-1693005

Cited by 70 publications

(90 citation statements)

References 81 publications

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“…Treatment, including IVIG or plasma exchange, should be started promptly before irreversible nerve damage occurs. 3,4 In our case, the patient's course can be explained by delayed detection of GBS and involvement of the gastrointestinal, autonomic, and respiratory systems. There was further evolution of bacterial translocation and concomitant systemic invasive infection.…”

Section: Discussionmentioning

confidence: 71%

“…3 Findings in our case are instructive in that early recognition of any atypical symptoms of GBS and prompt immunotherapy are critical for reducing morbidity and mortality. 3,4,7 List of abbreviations GBS, Guillain-Barr e syndrome. CT, computed tomography.…”

Section: Resultsmentioning

confidence: 99%

“…2,3 GBS is thought to be caused by aberrant immune responses triggered by antigenic stimuli shortly after antecedent infections (often mild respiratory or gastrointestinal illness) or vaccination. 4 This aberrant response generates autoimmune antibodies against peripheral nerves, thereby resulting in demyelination or axonal damage with subsequent conduction blockage. Diagnosis of GBS is based on the clinical picture, cytoalbuminic dissociation in cerebrospinal fluid, and electrophysiological abnormalities.…”

Section: Discussionmentioning

confidence: 99%

“…Diagnosis of GBS is based on the clinical picture, cytoalbuminic dissociation in cerebrospinal fluid, and electrophysiological abnormalities. 3,4 Generally, approximately 65% of patients with GBS show dysautonomia, which commonly occurs in advanced stages. This condition can lead to broad systemic consequences, and can manifest as cardiac dysrhythmias, fluctuation in blood pressure, or vasomotor or gastrointestinal dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…This condition can lead to broad systemic consequences, and can manifest as cardiac dysrhythmias, fluctuation in blood pressure, or vasomotor or gastrointestinal dysfunction. 3,4 Ileus refers to complete or partial disruption in intestinal transit either by functional (adynamic or paralytic) or mechanical bowel obstruction. 1 In the present case, abdominopelvic CT excluded organic obstruction, and gastrointestinal functional examinations confirmed paralytic ileus.…”

Section: Discussionmentioning

confidence: 99%

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Paralytic ileus as the presenting symptom for Guillain–Barré syndrome: a case report

Lee

et al. 2019

J Int Med Res

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Guillain–Barré syndrome (GBS) is an acute neuroimmunological disorder characterized by rapidly ascending symmetrical limb weakness, areflexia, and sensory deficits. Approximately 65% of patients with GBS present with autonomic dysfunction, which commonly occurs in advanced stages. However, paralytic ileus, a sign of gastrointestinal dysautonomia, is rare as the presenting feature in GBS before motor weakness becomes evident. We report the case of a 54-year-old man admitted to the Emergency Department with paralytic ileus as the prodromal feature in early-stage GBS. Total parenteral feeding and prokinetic use were initiated, but no clinical improvement was observed. The patient showed rapid progression to quadriplegia, which was ultimately determined to be respiratory muscle failure requiring mechanical ventilation and intensive care unit admission. He underwent 5 days of intravenous immunoglobulin therapy and muscle strength was partially improved thereafter. However, the patient’s enteral nutritional support was undesirable because of persistent poor gastric emptying complicated by fungemia and profound sepsis throughout the hospital course. Finally, he died 1 month after admission. Ignorance of this unusual prodrome to GBS could result in delayed treatment, along with potential progression to life-threatening events. Early recognition of GBS and prompt immunotherapy are critical for reducing morbidity and mortality.

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Section: Discussionmentioning

confidence: 71%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Paralytic ileus as the presenting symptom for Guillain–Barré syndrome: a case report

Lee

et al. 2019

J Int Med Res

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About a rare association: Guillain–Barré Syndrome and polymyositis

Chabchoub

Snoussi

Ammar

et al. 2022

Clinical Case Reports

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Guillain-Barré syndrome (GBS) and polymyositis (PM) are two rare autoimmune diseases, one of which affects the peripheral nervous system and other the muscle. We report the case of a young woman with no previous medical history who was hospitalized with an ascending paralysis associated with acute respiratory failure due to a GBS. The patient was treated with plasmapheresis with unfavorable outcome and permanent proximal muscular disability. The diagnosis of an associated PM was retained based on biological myolysis and the results of electromyography and muscular biopsy. To our knowledge, this association of GBS and PM has been reported only once in the literature. The search for syndromic associations in the presence of an autoimmune helps to avoid diagnostic errors.

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Patients' attitude towards vaccination after Guillain Barré syndrome

Holtz

Grimm²,

Axer

2021

Health Science Reports

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Background and Aims Guillain Barré syndrome (GBS) could be triggered by an infectious disease but by vaccination as well. Thus, suffering GBS may influence patients' attitudes towards vaccination. Methods An anonymous questionnaire consisting of the Overall Neuropathy Limitations Score (ONLS), the short form‐36 health survey (SF‐36), and questions addressing patients' attitude towards vaccination was sent to members of a German GBS support group and to patients with GBS diagnosis who were treated at Jena University Hospital. Results Ninety‐seven questionnaires clearly stated GBS as a diagnosis and were included in the analysis. Although 19.6% of the GBS patients reported having no disability in the long‐time follow‐up, a considerable number of patients still had persistent neurological symptoms; 74.2% of the GBS patients reported being able to walk at least 10 m independently. However, 5.2% were restricted to wheelchair. The patients reached lower scores in all domains of quality of life compared to German controls. Moreover, patients showed a more critical attitude towards vaccination compared to a German representative survey. Fewer patients (58.8%) received a vaccination after suffering from GBS than before (77.3%). Every tenth patient believed that vaccination was the trigger for the GBS. 32% of the patients did not receive a vaccination in the last 5 years mainly because of the fear of adverse effects (32%) or disadvise of the general practitioners (25.8%). Discussion Although the risk of relapse following immunization may be rather low, uncertainties and fears still impair the counseling of these patients by their medical practitioner.

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Guillain–Barre Syndrome

Cited by 70 publications

References 81 publications

Paralytic ileus as the presenting symptom for Guillain–Barré syndrome: a case report

Paralytic ileus as the presenting symptom for Guillain–Barré syndrome: a case report

About a rare association: Guillain–Barré Syndrome and polymyositis

Patients' attitude towards vaccination after Guillain Barré syndrome

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