Guillain-Barré syndrome associated with H1N1 vaccination

Marin, Luís Fabiano; Abrahão, Ayessandro; Carvalho, Flávia Chiva; Santos, William Adolfo Celso dos; Dallalba, Cleber C.; Barcelos, Lorena Broseghini; Silva, Gisele Sampaio; Oliveira, Acary Souza Bullé

doi:10.1590/s0004-282x2010000600029

Cited by 6 publications

(6 citation statements)

References 4 publications

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“…The association between GBS and influenza vaccination was again revitalized in 2009 during the “swine flu” influenza A (H1N1) virus pandemic and the subsequent launch of mass immunization campaigns in several countries. Since then several cases of GBS and Miller Fisher syndrome after influenza vaccination have been reported (Marin et al, ; Tremblay et al, ; Shoamanesh et al, ) . However, epidemiological studies and analysis of passive surveillance databanks could not find an increased risk for the occurrence of GBS after A/H1N1/2009 vaccination so far.…”

Section: Epidemiologymentioning

confidence: 99%

Recent developments and future directions in Guillain‐Barré syndrome

Lehmann

Hughes

Kieseier

et al. 2012

J Peripheral Nervous Sys

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Guillain-Barré syndrome (GBS) encompasses a spectrum of acquired neuropathic conditions characterized by inflammatory demyelinating or axonal peripheral neuropathy with acute onset. Clinical and experimental studies in the past years have led to substantial progress in epidemiology, pathogenesis of GBS variants, and identification of prognostic factors relevant to treatment. In this review we provide an overview and critical assessment of the most recent developments and future directions in GBS research.

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Section: Epidemiologymentioning

confidence: 99%

Recent developments and future directions in Guillain‐Barré syndrome

Lehmann

Hughes

Kieseier

et al. 2012

J Peripheral Nervous Sys

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“…The Institute of Medicine stated in 2011 that "an association cannot be confidently ruled out, particularly for future vaccine strains" [7]. Indeed, several cases describing a possible association have previously been reported [8,9], and their conclusions are consistent with a number of recent studies [10][11][12] and meta-analysis [13], which suggest the presence of a very small but quantifiable attributable risk (approximately 1 -2 excess cases per one million vaccinated individuals).…”

Section: Discussionmentioning

confidence: 81%

Guillain-Barre Syndrome Following Seasonal Influenza Vaccination

Mak¹

2017

J Neurol Res

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A 77-year-old man with a background of intracranial hemorrhage and hemophilic arthropathy presented with progressive weakness of all four limbs. His symptoms started acutely 8 days after a seasonal influenza vaccination. Physical examination revealed symmetrical proximal muscle weakness and generalized areflexia. Common infectious triggers of Guillain-Barre syndrome (GBS) were ruled out. Neurophysiological studies demonstrated features consistent with GBS. The patient's hospital stay was extensive and complicated by various comorbidities. Despite intravenous immunoglobulin (IVIG) treatment, the symptoms progressed to involve respiratory muscles and the patient was admitted to the intensive care unit. The patient's condition gradually improved after a further course of IVIG, and he was discharged 15 weeks post-admission with ongoing community rehabilitation. The temporal relationship between influenza vaccination and GBS development in this case was suggestive of a vaccineinduced cause, and the clinical implications of this association warrant further research.

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“…En todos los países en que se utilizó las vacunas monovalentes A(H1N1) 2009, la relación riesgo-beneficio continuó a favor de las vacunas; de otro modo no hubieran sido empleadas. Sin embargo, se presentaron algunas RAM severas o graves por vacunas A(H1N1) 2009 en Corea, donde resultaron 29 personas con G-B semanas después de la administración (21) y lo mismo en dos adultos en Sao Paulo (22) , así como neuritis óptica bilateral y encefalomielitis en un niño sano con dos dosis de dicha vacuna (23) . En Francia, las vacunaciones se iniciaron en octubre de 2009 para los trabajadores de salud de un hospital, pero durante la primera semana solo acudieron 129 trabajadores, de 1870 (24) .…”

Section: Discussionunclassified

Reacciones adversas a la vacuna contra influenza A (H1N1) en trabajadores de salud de una institución pública peruana

Álvarez-Falconí

Sánchez-Hurtado

2013

An Fac med

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Introducción: En abril de 2009 se produjo un brote de influenza en la frontera de México y EE UU por el nuevo virus A(H1N1) 2009. La pandemia no fue severa y la vacuna aplicada en diversos países produjo diversas reacciones adversas a medicamentos (RAM). Objetivos: Evaluar la posible relación entre las RAM notificadas espontáneamente y la vacunación en trabajadores de salud de un instituto. Así mismo, identificar tópicos afines a las RAM por dicha vacuna. Diseño: Estudio prospectivo y descriptivo basado en la notificación espontánea. Institución: Local central del Instituto Nacional de Salud en Lima. Participantes: Trabajadores de salud. Metodología: Las RAM notificadas espontáneamente fueron registradas en Hojas RAM. Se aplicó un algoritmo para buscar una relación causa-efecto. Principales medidas de resultados: Reacciones adversas a la vacuna influenza A(H1N1). Resultados: Hubo tres notificaciones espontáneas entre 148 trabajadores de salud vacunados (2%) contra la influenza A(H1N1) 2009. La relación causa-efecto fue ‘cierta’ para fiebre y fatiga y ‘posible’ para afecciones respiratorias en tres mujeres (faringitis aguda, catarro nasal agudo, bronquitis catarral). Conclusiones: Entre los pocos trabajadores de salud que presentaron RAM, las afecciones respiratorias con una relación considerada ‘posible’ podría interpretarse que las mujeres serían más sensibles para esa RAM comparadas con los varones. Las RAM fiebre y fatiga alcanzaron una relación considerada ‘cierta’. La menor cantidad de infectados en personas de tercera edad en el país y en otros podría explicarse por la presencia de ‘anticuerpos protectores’ en ellos.

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Guillain-Barré syndrome associated with H1N1 vaccination

Cited by 6 publications

References 4 publications

Recent developments and future directions in Guillain‐Barré syndrome

Recent developments and future directions in Guillain‐Barré syndrome

Guillain-Barre Syndrome Following Seasonal Influenza Vaccination

Reacciones adversas a la vacuna contra influenza A (H1N1) en trabajadores de salud de una institución pública peruana

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