Guillain-Barré syndrome associated with high titers of anti-GM1 antibodies

Development of an Immunoassay for Rapid Detection of Ganglioside GM 1 Mimicry in Campylobacter jejuni Strains

“…Gangliosides have been extensively studied as possible host antigens for autoimmune disease, since serum antibodies against gangliosides, especially GM 1 , are found in GBS sera, particularly when preceded by C. jejuni infection (15,35,44,59,60,63). Molecular mimicry of gangliosides by core OSs of certain C. jejuni serotypes associated with GBS has been established (5,7,8,10,29,31,32,56,61), but LPSs from only a few C. jejuni GBS or MFS isolates have been studied at the molecular level.…”

“…In a Japanese study, 81% of C. jejuni isolates from GBS patients belonged to serotype O:19 (20), and, other studies have shown an association with other serotypes (19,31,33,37,45,48,58). Autoreactive antibodies to gangliosides, especially GM 1 , are found in 30% of GBS patient sera, particularly after C. jejuni infection (15,19,26,35,36,49,58,59,63). Thus, it is currently hypothesized that antiganglioside antibodies may be induced as a result of molecular mimicry of peripheral nerve gangliosides by structurally similar C. jejuni LPSs (49,59).…”

Application of Liposome Immune Lysis Assay for Studies on Anti-Ganglioside Antibodies.

“…[15]. Our study showed that the incidence of positive cases by ELISA was significantly higher in patients with GBS than in normal controls.…”

Campylobacter jejuni bacteremia and Guillain-Barré syndrome in a renal transplant recipient

“…In GBS patients with C. jejuni infection, certain serotypes, such as PEN 19 or Lior 11, are greatly overrepresented compared to controls without neurological disease [lo, 111. Antibodies antiganglioside GM1 have been detected in patients with GBS [8,19,31,36]. It is of interest that about 50% of patients with anti-GM1 antibodies have evidence of preceding C. jejuni infection [12, 311.…”