Guillain–Barré syndrome complicating dengue fever: Two case reports

Boo, Yang Liang; Aris, Mohd Azman M.; Chin, Pek Woon; Sulaiman, Wan Aliaa Wan; Basri, Hamidon; Hoo, Fan Kee

doi:10.1016/j.tcmj.2015.09.007

Cited by 11 publications

(8 citation statements)

References 11 publications

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“…In the majority of cases, the electrodiagnosis was in keeping with AIDP with several authors describing prolonged distal latencies, slow conduction velocities and delayed F waves 30–34 36 37. In three cases where electrophysiology data were not provided, the authors concluded axonal subtypes of GBS (1 AMAN and 2 acute motor and sensory polyneuropathy) 35 38. Our own unpublished observation of dengue-associated GBS would support AIDP.…”

Section: Methodssupporting

confidence: 57%

Zika virus infection and Guillain-Barré syndrome: a review focused on clinical and electrophysiological subtypes

Uncini

Shahrizaila

Kuwabara

2016

J Neurol Neurosurg Psychiatry

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In 2016, we have seen a rapid emergence of Zika virusassociated Guillain-Barré syndrome (GBS) since its first description in a French-Polynesian patient in 2014. Current evidence estimates the incidence of GBS at 24 cases per 100 000 persons infected by Zika virus. This will result in a sharp rise in the number of GBS cases worldwide with the anticipated global spread of Zika virus. A better understanding of the pathogenesis of Zika-associated GBS is crucial to prepare us for the current epidemic. In this review, we evaluate the existing literature on GBS in association with Zika and other flavivirus to better define its clinical subtypes and electrophysiological characteristics, demonstrating a demyelinating subtype of GBS in most cases. We also recommend measures that will help reduce the gaps in knowledge that currently exist.

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Section: Methodssupporting

confidence: 57%

Zika virus infection and Guillain-Barré syndrome: a review focused on clinical and electrophysiological subtypes

Uncini

Shahrizaila

Kuwabara

2016

J Neurol Neurosurg Psychiatry

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“…The symptoms during dengue fever usually include high fever, severe headache, retro-orbital pain, arthralgia, myalgia, nausea, vomiting, and rash. A severe form of dengue may be lethal to individuals with symptoms including bleeding gums, restlessness, fatigue, blood in vomit, and thrombocytopenia [ 25 ]. Severe forms of DENV infection mostly occur due to antibody-dependent enhancement (ADE), where pre-existing antibodies from a primary infection bind to an infecting DENV particle during secondary infection with a different DENV serotype [ 61 ].…”

Section: Flaviviruses and Ocular Complicationsmentioning

confidence: 99%

Ocular Manifestations of Emerging Flaviviruses and the Blood-Retinal Barrier

Singh

Kumar

2018

Viruses

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Despite flaviviruses remaining the leading cause of systemic human infections worldwide, ocular manifestations of these mosquito-transmitted viruses are considered relatively uncommon in part due to under-reporting. However, recent outbreaks of Zika virus (ZIKV) implicated in causing multiple ocular abnormalities, such as conjunctivitis, retinal hemorrhages, chorioretinal atrophy, posterior uveitis, optic neuritis, and maculopathies, has rejuvenated a significant interest in understanding the pathogenesis of flaviviruses, including ZIKV, in the eye. In this review, first, we summarize the current knowledge of the major flaviviruses (Dengue, West Nile, Yellow Fever, and Japanese Encephalitis) reported to cause ocular manifestations in humans with emphasis on recent ZIKV outbreaks. Second, being an immune privilege organ, the eye is protected from systemic infections by the presence of blood-retinal barriers (BRB). Hence, we discuss how flaviviruses modulate retinal innate response and breach the protective BRB to cause ocular or retinal pathology. Finally, we describe recently identified infection signatures of ZIKV and discuss whether these system biology-predicted genes or signaling pathways (e.g., cellular metabolism) could contribute to the pathogenesis of ocular manifestations and assist in the development of ocular antiviral therapies against ZIKV and other flaviviruses.

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“…dengue-related neurological presentation had been reported due to dengue-induced myelitis [6], hypokalemia [7], Guillain-Barre syndrome [8][9][10] and dengue myositis [11]. In our case, we believe that her symptoms resulted from a combination of spinal cord oedema and haemorrhage causing cord compression with concomitant denguerelated encephalitis and transverse myelitis.…”

Section: Similarmentioning

confidence: 64%

Spontaneous Spinal Subarachnoid Haemorrhage: A Rare Complication of Dengue Fever

Sharif¹,

Misnan²,

Saidon³

et al. 2017

JCHS

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A 37-year-old woman presented with a short history of fever and bilateral lower limb weakness. She also had impaired sensory function up to T4 spine level and lax anal tone. Laboratory investigations confirmed dengue infection with mild thrombocytopenia. MRI of the spine showed a spinal subarachnoid haemorrhage from the level of T4 till T9. Despite medical and surgical interventions, her lower limb weakness persists. A high index of suspicion is needed to recognise dengue-related neurological complications. This diagnosis should be considered in any patients from dengue endemic areas presenting with acute febrile illness with atypical neurological manifestations.

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Guillain–Barré syndrome complicating dengue fever: Two case reports

Abstract: Guillain–Barré syndrome is a rare neurological manifestation associated with dengue infection. More common antecedent infections include Campylobacter jejuni and Cytomegalovirus infection. Here, we report two cases of Guillain–Barré syndrome complicating dengue infection.

Cited by 11 publications

References 11 publications

Zika virus infection and Guillain-Barré syndrome: a review focused on clinical and electrophysiological subtypes

Zika virus infection and Guillain-Barré syndrome: a review focused on clinical and electrophysiological subtypes

Ocular Manifestations of Emerging Flaviviruses and the Blood-Retinal Barrier

Spontaneous Spinal Subarachnoid Haemorrhage: A Rare Complication of Dengue Fever

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