Guillain-Barré syndrome during the Zika virus outbreak in Sucre, Colombia, 2016

Villamil-Gómez, Wilmer E.; Sánchez-Herrera, Álvaro Rosendo; Hernández, Hugo Orlando; Hernández-Iriarte, Jayder; Díaz-Ricardo, Kelly; Castellanos, Jaime E.; Villamil-Macareno, Wilmer de Jesús; Rodríguez‐Morales, Alfonso J.

doi:10.1016/j.tmaid.2017.03.012

Cited by 25 publications

(17 citation statements)

References 6 publications

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“…http://dx.doi.org/10.1101/186155 doi: bioRxiv preprint first posted online Sep. 8, 2017; studied here displayed any of the hallmark symptoms (e.g., fever, maculopapular rash, 250 conjunctivitis, etc.) that have been associated with overt Zika fever or those that have been 251 associated with neurologic disease in adults in rare instances (e.g., Guillain-Barré 252 syndrome 38,39 , encephalitis, meningoencephalitis, and myelitis 40 ); therefore, outcomes observed 253 here may more closely parallel what has been reported during adult human infections. 254…”

Section: Cc-by-nc-nd 40 International License Peer-reviewed) Is the mentioning

confidence: 59%

Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques

Lalli

et al. 2017

Preprint

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For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics. Mouse and nonhuman primate models now serve as useful platforms to study Zika virus (ZIKV) pathogenesis, candidate therapies, and vaccines, but they rely on needle inoculation of virus: the effects of mosquito-borne infection on disease outcome have not been explored in these models. To model vector-borne transmission of ZIKV in nonhuman primates, we infected Aedes aegypti mosquitoes with ZIKV and allowed them to feed on four ZIKV-naive rhesus macaques. We compared ZIKV replication kinetics and tissue distribution between animals that were subcutaneously inoculated with 104 plaque-forming units of ZIKV and those that were exposed via mosquito bite. Here, we show that infection via mosquito bite delays ZIKV replication to peak viral loads in rhesus macaques. Importantly, in mosquito-infected animals ZIKV tissue distribution was limited to hemolymphatic tissues, female reproductive tract tissues, kidney, and liver, potentially emulating key features of human ZIKV infections, most of which are characterized by mild or asymptomatic disease. This newly developed system will be valuable for studying ZIKV disease because it more closely mimics human infection by mosquito bite than needle-based inoculations.

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Section: Cc-by-nc-nd 40 International License Peer-reviewed) Is the mentioning

confidence: 59%

Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques

Lalli

et al. 2017

Preprint

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“…Although ZIKV infection is usually benign, the clinical evolution can even be fatal in non-GBS cases (Arzuza-Ortega et al, 2016;Sarmiento-Ospina et al, 2016;Rodriguez-Morales et al, 2019). In the context of GBS, countries at risk of ZIKV epidemics require adequate intensive care bed capacity for the management of severe cases (Villamil-Gomez et al, 2017;Dos Santos et al, 2016;. In fact, the GBS cases in the present study were from areas affected by ZIKV epidemics , as well as previous DENV and CHIKV (Zambrano et al, 2017).…”

mentioning

confidence: 67%

Guillain–Barré syndrome associated with Zika virus infection in Honduras, 2016–2017

Zambrano

Fuentes-Barahona

Soto-Fernández

et al. 2019

International Journal of Infectious Diseases

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“…Additionally, further work should quantify the effect that cross-border movement has on the distribution of ZIKV in Colombia and all of Latin America, to allow for the development emergency preparedness protocols in newly affected areas [5,6,14,15]. Also in the future, GIS-based maps of ZIKV congenital syndrome, ZIKV-associated Guillain-Barré syndrome and even of deaths, would be useful [19,20].…”

Section: N Discussionmentioning

confidence: 99%

Spatial distribution of Zika virus infection in northeastern Colombia

Rodríguez‐Morales

Haque

Ball

et al. 2016

Bull. World Health Organ.

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Z ika virus (ZIKV) infection is causing epidemics in Latin America [1]. Colombia has officially reported a total of 58,838 cases of ZIKV infection in the first 32 epidemic weeks (21 in 2015 and 11 in 2016) [2]. According to the Pan American Health Organization (PAHO) and the World Health Organization (WHO), Colombia has fewer cases than Brazil in terms of absolute number of infections (58,838 cases, 4% laboratory confirmed in Colombia compared to 72,596 cases, 0.74% laboratory confirmed in Brazil) [3,4]. However, Colombia has a higher per capita incidence rate (IR) than Brazil due to its smaller population size (209,157,170 pop, IR = 34.71 cases/100,000 population in Brazil; 48,747,632 population, IR=120.70 cases/100,000 population in Colombia) [4]. The ZIKV incidence rate is 3.5 times higher in Colombia than in Brazil. Thus, Colombia currently faces the greatest burden of disease for ZIKV, worldwide.

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Guillain-Barré syndrome during the Zika virus outbreak in Sucre, Colombia, 2016

Cited by 25 publications

References 6 publications

Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques

Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques

Guillain–Barré syndrome associated with Zika virus infection in Honduras, 2016–2017

Spatial distribution of Zika virus infection in northeastern Colombia

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