Guillain-Barré syndrome in a patient previously diagnosed with COVID-19

Abstract

As the COVID-19 pandemic continues to progress, the medical community is rapidly trying to identify complications and patterns of disease to improve patient outcomes. In a recent systematic review, it has been reported that isolated cases of Guillain-Barre Syndrome (GBS) have occurred secondary to COVID-19 infection. GBS is defined as a rare, but potentially fatal, immune mediated disease of peripheral nerves and nerve roots that is usually triggered by infections. The incidence of GBS can therefore increase during outbreaks of infectious diseases, as was seen during the Zika virus epidemics in 2013 in French Polynesia and 2015 in Latin America. While several cases of GBS secondary to COVID-19 infection have been reported in Italy, only one case has been reported in the United States (US). The reported case in the US was a 54-year old male. We present a case of GBS secondary to a COVID-19 infection and believe this to be the first documented female case in the US and the second documented case in the US overall. The presented case aims to supplement the existing body of knowledge and to assist clinicians in managing complications of COVID-19.

A unique association of bifacial weakness, paresthesia and vestibulocochlear neuritis as post COVID 19 manifestation in pregnant women

“…The underlying mechanisms of GBS in COVID-19 are not well understood. It can be likely a postinfectious immune-mediated mechanism or infrequently a para-infectious phenomenon [ 3 ]. Hutchins et al .…”

COVID-19 infection presented as Guillain-Barre Syndrome: Report of two new cases and review of 116 reported cases and case series

“…After thorough literature review, we found a substantial number of reported cases and case series of Covid-19 infection presented with GBS. Table 1 summarizes demographic, type of relationship with Covid-19, clinical and GBS sub-types, response to specific GBS treatment, and outcome of different GBS cases who presented in concurrent with Covid 19 infection [[ [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] ],[ [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] ...…”

“…Common neurological symptoms of COVID-19 are headache, dizziness, dysgeusia/ageusia, hyposmia/anosmia, seizure, stroke, and encephalopathy [ 2 ]. There have been reported cases of Guillain-Barré Syndrome (GBS) associated with COVID-19 from different parts of the world [[ [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] ],[ [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] ,…”

Neuromuskuläre Komplikationen einer SARS-CoV-2-Infektion – Teil 1: periphere Nerven

“…Das Konzept zur Pathogenese des Guillain-Barré-Syndroms (GBS) als Prototyp einer postinfektiösen autoimmunen Neuropathie [43] sowie Fallberichte und Fallserien aus besonders von der Pandemie betroffenen Ländern wie Spanien [10], Italien [14], Indien [35] und den USA [8] Neben GBS wurden auch mehrere Fälle eines Miller Fisher-Syndroms (MFS) bei SARS-CoV-2-positiven Patienten be-richtet [4]. Auffallend ist, dass oft keine Anti-Gangliosid-Antikörper im Serum nachweisbar waren.…”