Guillain-Barré syndrome in children – High occurrence of Miller Fisher syndrome in East Asian region

Chiu, Annie Ting Gee; Chan, Ricky Wing Ki; Yau, Maggie Lo Yee; Yuen, Angus Chi Lap; Lam, Alva King Fai; Lau, Shirley Wai Yin; Lau, Alan Ming Chung; Fung, Sharon Tsui Hang; Hung, Kam; Lau, Christine Wai Ling; Yau, Man Mut; Ko, Chun Hung; Tsui, Kwing Wan; Kwan, Che; Tai, Shuk Mui; Yau, Eric Kin Cheong; Fung, Eva; Wu, Shun Ping; Kwong, Karen L.; Chan, Sophelia Hoi Shan

doi:10.1016/j.braindev.2022.07.003

Cited by 5 publications

(3 citation statements)

References 54 publications

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“…In the paediatric population, there is less disproportion associated with the predominant gender prevalence of the disease, and is related to the pre-pubertal age of the patients [13,36]. However, most studies show no significant correlation between gender and the course, complications, and mortality of the disease [33,35].…”

Section: Discussionmentioning

confidence: 99%

“…Blood AGAs level tests are known for their limited usefulness; positive results are helpful for diagnosis, but negative results do not rule out GBS [20]. Positive results are usually found in MFS (90-100% of cases) [20,35]. Gadolinium-enhanced MRI and nerve ultrasound appear to be new, non-invasive diagnostic methods, but both require further study [21,25,26].…”

Section: Discussionmentioning

confidence: 99%

“…In 60% of cases, the results suggested acute inflammatory demyelinating polyneuropathy [23]. Typical changes for AIDP include slowed motor and sensory nerve conduction, and high F-wave latency or conduction block [24]. The average time from onset of symptoms to nerve conduction study was nine days.…”

Section: Diagnostic Processmentioning

confidence: 97%

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Guillain-Barré syndrome in childhood – what we know and where we are? A therapeutically difficult problem

Chrościńska-Krawczyk,

Ziółkiewicz,

Jartych

et al. 2024

J Pre Clin Clin Res.

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Introduction and Objective. Guillain-Barré syndrome (GBS) is a complex clinical entity with an autoimmune basis. It is considered the most common cause of acute neuromuscular paralysis in children. The incidence of GBS is approximately 0.34 per 100 000 cases annually, with a higher prevalence in the male population. The cause of the incidence is considered to be a complication of infection or vaccination. Review Methods. The studies cited in the presented review were selected from PUBMED. The key words used for the search included: 'Guillain-Barré syndrom', 'Guillain-Barré treatment', and 'Guillain-Barré therapeutic methods'. Articles not written in English, conference abstracts only and duplicated papers were excluded. Brief description of the state of knowledge. In the 19th century, abnormalities in albimuno-cytological dissection were considered to be the cause, but today diagnostic criteria have evolved. The most important element in the diagnosis of patients is the analysis of cerebrospinal fluid and nerve conduction studies. Possible pathogens that may cause symptoms of the disease include viruses such as Epstein-Barr virus, varicella, cytomegalovirus, and SARS-CoV-2. GBS manifests itself with numerous neurological and cardiovascular symptoms, including bilateral limb weakness, facial paralysis or cardiac arrhythmias. Patient treatment includes immunotherapy immediately after diagnosis. Summary. GBS is a rapidly progressive and difficult to treat clinical entity. It is important to make a timely diagnosis and immediately implement therapy to reduce the risk of death. Further clinical research is needed to find new therapeutic options for young patients.

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Section: Discussionmentioning

confidence: 99%