Guillain–Barré syndrome–like–onset neurosarcoidosis positive for immunoglobulin G anti-N-acetylgalactosaminyl-GD1a antibody

Chatani, H.; Tanaka, Masami; Nagata, Takuma; Araki, Takehisa; Kusunoki, Susumu

doi:10.1016/j.jocn.2013.01.015

Cited by 8 publications

(8 citation statements)

References 5 publications

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“…Since GalNAc-GD1a-containing cells have not been reported in the past, even neural tissue-derived cells, this is a first report of GalNAc-GD1a-containing cells. GalNAc-GD1a was characterized as a target antigen as to antibodies generated by infection with enterocolitis-associated bacteria such as Campylobacter jejuni, and with cytomegalovirus as a trigger on the onset of autoimmune neuropathies, such as the Guillain-Barré and Tolosa-hunt syndromes [18,[25][26][27][28]. Since GM2 determinant was also detected in the lipooligosaccharides from C. jejuni [29], it was revealed to exhibit a strong immunogenicity in the gut-associated immune system to yield anti-GM2 antibodies, and the resulting antibodies were thought to react with GalNAc-GD1a more strongly than with GM2 in neural tissues to disturb the neural functions through antibody-induced inflammation, leading to neuropathies.…”

Section: Discussionmentioning

confidence: 99%

“…Since GM2 determinant was also detected in the lipooligosaccharides from C. jejuni [29], it was revealed to exhibit a strong immunogenicity in the gut-associated immune system to yield anti-GM2 antibodies, and the resulting antibodies were thought to react with GalNAc-GD1a more strongly than with GM2 in neural tissues to disturb the neural functions through antibody-induced inflammation, leading to neuropathies. Detection of antibodies against GalNAc-GD1a was useful as a diagnostic marker for autoimmune neuropathies [18,[26][27][28][29], and Boku, OMC-4 and HCA-1 cells would be applicable as sources for preparation of GalNAc-GD1a and as target cells for the detection of anti-GalNAc-GD1a antibodies in sera of patients with autoimmune neuropathies. In fact, in our preliminary experiment, anti-GalNAc-GD1a IgG antibodies could be detected on immunohistochemical staining of Boku cells with sera of patients suffering from chronic motor axonal neuropathy [30].…”

Section: Discussionmentioning

confidence: 99%

“…To further explore transformation-related changes in glycolipids of gynecological carcinomas, we subsequently determined them in tissues and cells of cervical carcinomas, whose onset was due to infection with papilloma virus, and found that all cells established from different types, i.e., squamous cell carcinomas, adenocarcinomas, adenosquamous carcinomas and small cell carcinomas, commonly expressed unique glycolipids with GM2-carbohydrate determinant belonging to ganglio-series, i.e., GM2, GalNAc-GM1b and GalNAc-GD1a. In particular, GalNAc-GD1a with GM2-determinant, which is a minor constituent in the human brain and is an antigen of autoimmune peripheral neuropathies [18,19], was detected in relatively high amounts in three out of seven cell lines. Since elevated amounts of GM2 have been previously reported as an event after SV-40 virus-dependent transformation of human fibroblasts and neural cells, the expression of unique gangliosides with GM2 determinant in cervical carcinoma-derived cell lines is probably a papilloma virus-related phenomenon, which is not observed in endometrial and ovarian carcinomas-derived cell lines [20].…”

Section: Introductionmentioning

confidence: 99%

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Enhanced expression of unique gangliosides with GM2-determinant in human uterine cervical carcinoma-derived cell lines

et al. 2016

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Monoclonal antibody YHD-06 generated by immunization with GM2 reacted with gangliosides with GM2-determinant, i.e., GM2, GalNAc-GM1b and GalNAc-GD1a, among which GalNAc-GD1a was characterized as an antigen of autoimmune peripheral neuropathies including Guillain-Barré syndrome. When glycolipids were examined by TLC-immunostaining with YHD-06 in seven human cervical carcinoma-derived cell lines, GM2 was found in all cell lines, amounting to 15.5 % to 57.5 % of total gangliosides. Whereas GalNAc-GD1a was present in three cell lines, amounting to 5.4-17.5 % of total gangliosides, and GalNAc-GM1b in four cell lines in amounts of less than 2 %. The elevated amounts of gangliosides with GM2 determinant were closely correlated with the relative intensities of gene expression of GalNAc transferase, this being characteristic of cervical carcinoma-derived cells. However, in tissues from patients with several histological types of cervical carcinomas, GM3 was ubiquitously expressed in amounts of more than 66 % of total gangliosides, GM2 was expressed in only five of 15 tissues, and both GalNAc-GM1b and GalNAc-GD1a were not even detected in trace amounts. Since GM1 was detected in all tissues in amounts of less than 0.06 μg/mg dried tissue, all cervical carcinoma tissues were revealed to exhibit GM2 synthesis, indicating that enhanced synthesis of gangliosides with GM2 determinant is a characteristic of cultivated cells in vitro. Similarly, although I(3)SO3-GalCer was not present in the squamous cell carcinoma (SCC) tissues, SCC-derived cells selectively expressed II(3)SO3-LacCer. Since enhanced synthesis of GM2 has been reported in SV-40 virus-transfected fibroblasts, papilloma virus might be involved in the expression of GM2 in cervical carcinoma-derived cells.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhanced expression of unique gangliosides with GM2-determinant in human uterine cervical carcinoma-derived cell lines

et al. 2016

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“…In the majority of previous studies, anti-ganglioside antibodies have been found in autoimmune neuropathies, particularly GBS (33,34). It was hypothesized that different sub-types of anti-ganglioside antibodies are associated with different GBS subtypes (35).…”

Section: Discussionmentioning

confidence: 99%

Toll-like receptor 2 and -4 are involved in the pathogenesis of the Guillain-Barré syndrome

Zhang

et al. 2015

Molecular Medicine Reports

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Abstract. Guillain-Barré syndrome (GBS) is an autoimmune disorder of the peripheral nervous system characterized by weakness in the limbs. To date, numerous hypotheses have been suggested to explain the pathogenesis of GBS; however, the pathogenesis of GBS remains to be elucidated. The aim of the present study was to investigate the association between Toll-like receptor (TLR) 2, TLR4 and GBS. Therefore, the mRNA of TLR2, TLR4, myeloid differentiation factor (MyD)88 and nuclear factor (NF)-κB of peripheral blood mononuclear cells (PBMCs) in patients with GBS and healthy controls was assessed. To confirm the function of TLR2 and TLR4 in the pathogenesis of GBS, PBMCs derived from patients with GBS and healthy controls were cultured with various TLR agonists. The levels of tumor necrosis factor (TNF)-α and interleukin (IL)-1β were measured in the culture supernatant and fasting serum was obtained for the detection of anti-ganglioside antibodies. The results revealed that the mRNA levels of TLR2, TLR4, MyD88 and NF-κB were significantly increased in patients with GBS compared with those in healthy controls (P=0.003, 0.017, 0.032 and 0.015, respectively). PBMCs from patients with GBS secreted higher levels of TNF-α and IL-1β than those from control subjects. The positive rate of immunoglobulin (Ig)G and IgM anti-ganglioside antibodies in patients with severe GBS was 42.86%, which was markedly higher than rates found in patients with mild GBS (9.09 and 18.18%, respectively). The results of the present study demonstrated that TLR2 and TLR4 are involved in the pathogenesis of GBS and that they and their associated signaling pathways may be targets for the treatment of GBS.

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“…These results suggest that our case had bilateral vagal nerve involvement that led to the bilateral vocal cord paralysis. We were able to rule out the possibility of GuillainBarré-like neuropathy of sarcoidosis in our case because the patient did not have the symptoms of an antecedent infection, a weakness of the extremities, a sensory disturbance or an albuminocytologic dissociation (23).…”

Section: Discussionmentioning

confidence: 89%

Sarcoidosis Presenting as Bilateral Vocal Cord Paralysis due to Bilateral Vagal Nerve Involvement

et al. 2016

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We herein report a rare case of sarcoidosis presenting as bilateral vocal cord paralysis due to bilateral vagal nerve involvement. A 72-year-old woman with uveitis of the left eye complained of hoarseness and aspiration due to bilateral vocal cord paralysis. An endobronchial needle aspiration biopsy specimen of the mediastinal lymph nodes showed non-caseating epithelioid cell granuloma. Total protein and cell concentrations in the cerebrospinal fluid were increased. We diagnosed her to have sarcoidosis with bilateral vagal nerve involvement. Corticosteroid therapy improved her symptoms of hoarseness and aspiration. Sarcoidosis should therefore be taken into consideration as a potential cause of bilateral vocal cord paralysis.

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Guillain–Barré syndrome–like–onset neurosarcoidosis positive for immunoglobulin G anti-N-acetylgalactosaminyl-GD1a antibody

Cited by 8 publications

References 5 publications

Enhanced expression of unique gangliosides with GM2-determinant in human uterine cervical carcinoma-derived cell lines

Enhanced expression of unique gangliosides with GM2-determinant in human uterine cervical carcinoma-derived cell lines

Toll-like receptor 2 and -4 are involved in the pathogenesis of the Guillain-Barré syndrome

Sarcoidosis Presenting as Bilateral Vocal Cord Paralysis due to Bilateral Vagal Nerve Involvement

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