Guillain-Barré syndrome, tuberculosis and inflammatory bowel disease: a multiple association

Abstract

Guillain-Barré syndrome (GBS) has been associated with both infective or non-infective aetiologies. GBS is usually preceded by acute respiratory or gastrointestinal infection but its association with tuberculosis has been exceptionally reported. Inflammatory bowel disease (IBD) is associated with clinical manifestations involving the neurological system, peripheral neuropathy is known to be related to IBD and, either demyelinating or axonal involvement of peripheral nerves have been described. We report an unusual case of GBS associated with lymph node tuberculosis and ulcerative colitis.

Concomitant Guillain–Barré Syndrome in a young Sri Lankan male with severe ulcerative colitis

“…The neurologic manifestations documented were in the form of myelopathy, myopathy,myasthenia gravis and cerebrovascular disorders[ 8 ]. Peripheral neuropathies related to IBD seems to be more frequent in Ulcerative Colitis, with a reported incidence of 1.9% but it seems that it is associated with a lower rate of demyelinating forms as compared to Crohn’s Disease [ 9 ].…”

Does Zika Really Have the Capacity to Affect the Nervous System and Cause Microcephaly or Intracranial Calcifications?

“…Not only has the association of GBS and TB been repeatedly reported [20]- [29], but in addition the tuberculosis bacilli has actually been demonstrated in the nerve roots at necropsy in patients with the salient features of the Guillain-Barre syndrome [30]. This led de la Torre, Morís, Martinez and Montez to conclude the need to consider TB in all patients with GBS [31].…”

Peripheral neuropathy: An underreported neurologic manifestation of inflammatory bowel disease

“…Studies have described demyelinating or axonal involvement of peripheral nerves in IBD, and both types of neuropathies may be acute or chronic (Table 2) [12][13][14][15][16][17][18][19][20][21][22].…”