Guillain–Barré syndrome variant with prominent facial diplegia, limb paresthesia, and brisk reflexes

Lehmann, Helmar C.; Macht, Stephan; Jander, Sebastian; Hartung, Hans‐Peter; Methner, Axel

doi:10.1007/s00415-011-6169-8

Cited by 18 publications

(17 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Treatment of patients with variant GBS with facial diplegia and paresthesia remains controversial [18]. Patients with GBS may be treated with plasmapheresis or intravenous immunoglobulin (IVIG) [19,22–26]. However, treatment is not always needed if the patient remains mobile one week after the initial onset of symptoms [18,20].…”

Section: Discussionmentioning

confidence: 99%

“…Glucocorticoid treatment has been also reported and found to be variably effective in patients with this rare variant of GBS [22], while patients with IgM antibodies to N-acetylgalactosaminyl GD1a (GalNAc-GD1a) and other gangliosides have responded to glucocorticoids [27,28]. Therefore, glucocorticoids may be useful for improvement of facial palsy in cases of GBS with facial diplegia and paresthesia, the action of which is thought to be due to its anti-inflammatory effects, and reduction of edema [27].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Guillain-Barré Syndrome: A Variant Consisting of Facial Diplegia and Paresthesia with Left Facial Hemiplegia Associated with Antibodies to Galactocerebroside and Phosphatidic Acid

et al. 2017

View full text Add to dashboard Cite

Patient: Male, 54Final Diagnosis: Guillain-Barré syndromeSymptoms: Paresthesia of extremities • unilateral facial palsyMedication: —Clinical Procedure: —Specialty: NeurologyObjective:Unusual clinical courseBackground:A rare variant of Guillain-Barré syndrome (GBS) consists of facial diplegia and paresthesia, but an even more rare association is with facial hemiplegia, similar to Bell’s palsy. This case report is of this rare variant of GBS that was associated with IgG antibodies to galactocerebroside and phosphatidic acid.Case Report:A 54-year-old man presented with lower left facial palsy and paresthesia of his extremities, following an upper respiratory tract infection. Physical examination confirmed lower left facial palsy and paresthesia of his extremities with hyporeflexia of his lower limbs and sensory loss of all four extremities. The differential diagnosis was between a variant of GBS and Bell’s palsy. Following initial treatment with glucocorticoids followed by intravenous immunoglobulin (IVIG), his sensory abnormalities resolved. Serum IgG antibodies to galactocerebroside and phosphatidic acid were positive in this patient, but not other antibodies to glycolipids or phospholipids were found. Five months following discharge from hospital, his left facial palsy had improved.Conclusions:A case of a rare variant of GBS is presented with facial diplegia and paresthesia and with unilateral facial palsy. This rare variant of GBS may which may mimic Bell’s palsy. In this case, IgG antibodies to galactocerebroside and phosphatidic acid were detected.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Guillain-Barré Syndrome: A Variant Consisting of Facial Diplegia and Paresthesia with Left Facial Hemiplegia Associated with Antibodies to Galactocerebroside and Phosphatidic Acid

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Further, the presence of abnormal root imaging does not correlate with electrophysiological or clinical parameters (Gorson et al, 1996). Contrast enhancement can also be found in affected cranial nerves in GBS variants with prominent cranial nerve involvement (Nagaoka et al, 1996;Garcia-Rivera et al, 2001;Hosoya et al, 2001;Lehmann et al, 2011). Spinal MRI may be considered if urinary retention at the onset raises the differential diagnosis of a compressive cord lesion.…”

Section: Symptoms and Diagnosismentioning

confidence: 99%

Recent developments and future directions in Guillain‐Barré syndrome

Lehmann

Hughes

Kieseier

et al. 2012

J Peripheral Nervous Sys

Self Cite

View full text Add to dashboard Cite

Guillain-Barré syndrome (GBS) encompasses a spectrum of acquired neuropathic conditions characterized by inflammatory demyelinating or axonal peripheral neuropathy with acute onset. Clinical and experimental studies in the past years have led to substantial progress in epidemiology, pathogenesis of GBS variants, and identification of prognostic factors relevant to treatment. In this review we provide an overview and critical assessment of the most recent developments and future directions in GBS research.

show abstract

“…During the course of illness, 24-60% of GBS patients develop facial nerve paresis, and almost all show it bilaterally 7 . Also, Miller Fisher syndrome is considered a variant of GBS, and FD may be seen 8 .…”

Section: Discussionmentioning

confidence: 99%

Facial diplegia: etiology, clinical manifestations, and diagnostic evaluation

Varol

Özdemir

Akıl

et al. 2015

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Objective Facial diplegia (FD) is a rare neurological manifestation with diverse causes. This article aims to systematically evaluate the etiology, diagnostic evaluation and treatment of FD. Method The study was performed retrospectively and included 17 patients with a diagnosis of FD. Results Patients were diagnosed with Guillain-Barré syndrome (GBS) (11), Bickerstaff’s brainstem encephalitis (1), neurosarcoidosis (1), non-Hodgkin’s Lymphoma (1), tuberculous meningitis (1) herpes simplex reactivation (1) and idiopathic (1). In addition, two patients had developed FD during pregnancy. Conclusion Facial diplegia is an ominous symptom with widely varying causes that requires careful investigation.

show abstract

Guillain–Barré syndrome variant with prominent facial diplegia, limb paresthesia, and brisk reflexes

Cited by 18 publications

References 11 publications

Guillain-Barré Syndrome: A Variant Consisting of Facial Diplegia and Paresthesia with Left Facial Hemiplegia Associated with Antibodies to Galactocerebroside and Phosphatidic Acid

Guillain-Barré Syndrome: A Variant Consisting of Facial Diplegia and Paresthesia with Left Facial Hemiplegia Associated with Antibodies to Galactocerebroside and Phosphatidic Acid

Recent developments and future directions in Guillain‐Barré syndrome

Facial diplegia: etiology, clinical manifestations, and diagnostic evaluation

Contact Info

Product

Resources

About