1994
DOI: 10.1002/nau.1930130206
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Guinea pig as an animal model for the study of urinary bladder function in the normal and obstructed state

Abstract: The guinea pig has become an excellent model for the study of mechanical and electrical mechanisms regulating bladder function in the normal and obstructed state. Much preliminary work has been done on the in vitro behavior of the detrusor smooth muscle. The tissue has permitted electrophysiological studies by sucrose gap, microelectrode, and patch clamp technique. Excellent urodynamic studies can be performed under anesthesia. A recent model of bladder obstruction has resulted in a source of tissue which is s… Show more

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Cited by 11 publications
(7 citation statements)
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“…In order to reveal the reasons for failure we developed an animal model in order to investigate the DUG. Animal models were used to examine new treatments of urinary incontinence or to examine urodynamics [Guan et al, 1994;Mostwin et al, 1994;Grunberger, 1987;Mokhless et al, 1988;Devendra et al, 1993;Sandford et al, 19941. So far we have not found any study on urethral pressure experiments in male goats.…”
Section: Discussionmentioning
confidence: 99%
“…In order to reveal the reasons for failure we developed an animal model in order to investigate the DUG. Animal models were used to examine new treatments of urinary incontinence or to examine urodynamics [Guan et al, 1994;Mostwin et al, 1994;Grunberger, 1987;Mokhless et al, 1988;Devendra et al, 1993;Sandford et al, 19941. So far we have not found any study on urethral pressure experiments in male goats.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, hyperreflexia is a major urodynamic consequence of symptomatic BPH [16]. In general, the urodynamic symptoms and bladder dysfunction of animals that demonstrate hyperreflexia are significantly greater than those of animals that do not show hyperreflexia [16]. We believe that hyperreflexia is the functional correlate of repetitive stimulation and induces a significant reduction in the tonic response to neuronal stimulation that results in the observed severity of bladder dysfunctions.…”
Section: -mentioning
confidence: 96%
“…Additionally, hyperreflexia is a major urodynamic consequence of symptomatic BPH [16]. In general, the urodynamic symptoms and bladder dysfunction of animals that demonstrate hyperreflexia are significantly greater than those of animals that do not show hyperreflexia [16].…”
Section: -mentioning
confidence: 99%
“…Using such an approach, several groups have studied the early molecular response of experimental animal models to partial bladder outlet obstruction [2,20,28]. In summary of these studies, a variety of bladder gene products (mRNAs) are altered in response to outlet obstruction.…”
Section: Altered Expression Of Bfgf and Tgf-fl By Bladder Outlet Obstmentioning
confidence: 99%
“…Both guinea pig [20] and rat [17,24] models undergo a comparable sequelae of events in association with bladder outlet obstruction.…”
mentioning
confidence: 99%