Guinea pig infection with the intracellular pathogen Rhodococcus equi

Bordin, Angela I.; Gressler, Letícia Trevisan; Alexander, Ellen Ruth; Sule, Preeti; Cirillo, Jeffrey D.; Edwards, John F.; Cohen, Noah D.

doi:10.1016/j.vetmic.2017.11.019

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…The possibility of post-viral immunosuppression after early herpes infection being connected with increased susceptibility to clinical rhodococcosis is worth considering. Other species, including humans, significantly less affected by environmental Rhodococcus, suffer from the disease mostly when immunologically deficient [4,10,[41][42][43][44][45]. What is more, susceptibility often occurs simultaneously with the highest exposure to a significant number of clinical and subclinical foals confirmed to have increased faecal shedding [36].…”

Section: Discussionmentioning

confidence: 99%

Less Typical Courses of Rhodococcus equi Infections in Foals

Rakowska

Marciniak-Karcz²,

Bereznowski

et al. 2022

Veterinary Sciences

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This article aims to present several interesting and less typical courses of Rhodococcus equi infections in foals, collected during the 2019–2021 foaling seasons in some Polish studs. The study was conducted by the Division of Veterinary Epidemiology and Economics, Warsaw University of Life Sciences—SGGW, and concentrated on ultrasonographic contribution to diagnostics and treatment of the disease. Among many standard cases of rhodococcal pneumonia, some rare ones occurred. The aforementioned issues include the potential contribution of rhodococcal infection to a grave outcome in a prematurely born filly, lost as a yearling, so-called “extrapulmonary disorders” (EPD), a hypothesis of inherited immunodeficiency with grave outcome in a breeding dam line from one stud, and macrolide-induced anhidrosis. The main benefit of this report would be to supplement the general picture of clinical rhodococcosis.

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Section: Discussionmentioning

confidence: 99%

Less Typical Courses of Rhodococcus equi Infections in Foals

Rakowska

Marciniak-Karcz²,

Bereznowski

et al. 2022

Veterinary Sciences

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“…In experimental airway infection with R. equi , guinea pigs, rats, and mice clear infection in a few days and do not develop pneumonia. [126][127][128] Despite being resistant toR. equi pneumonia and the absence of typical lung macroscopic lesions observed in foals, intravenous infections of mice are widely used as an experimental model because strains that are virulent in foals produce higher tissue concentrations in liver and spleen and greater lethality.…”

Section: Host Susceptibilitymentioning

confidence: 99%

Protective immune responses against Rhodococcus equi : an innate immunity-focused review

Bordin,

Silveira,

Cohen

et al. 2024

Preprint

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Rhodococcus equi causes pyogranulomatous pneumonia in foals and immunocompromised people. Despite decades of research efforts, no vaccine is available against this common cause of disease and death in foals. The purpose of this narrative review was to summarize the current understanding of interactions between R. equi and the host innate immune system, to describe features of the immune response that are associated with resistance or susceptibility to R. equi infection, and help guide strategies for developing novel approaches for preventing R. equi infections. Virulence of R. equi in foals has been attributed to the virulence associated protein A which allows intracellular survival in macrophages by preventing acidification of R. equi-containing vacuole. Additionally, foal susceptibility to R. equi infection is associated with immaturity and naivety of innate and adaptive immune systems, while adult horses with fully functional immune system are resistant to pneumonia. Specific interaction between R. equi and innate immune cells can result in bacterial survival or death; learning how to manipulate these responses to control infection is critical to prevent pneumonia in foals. Administration of live vaccines and stimulation of innate immune responses appears to improve foals’ immune response and has the potential to overcome the challenges of foal active vaccination and elicit protection against pneumonia.

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Rhodococcus equi–What is New This Decade?

Sanz¹

2023

Veterinary Clinics of North America: Equine Practice

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Guinea pig infection with the intracellular pathogen Rhodococcus equi

Cited by 5 publications

References 26 publications

Less Typical Courses of Rhodococcus equi Infections in Foals

Less Typical Courses of Rhodococcus equi Infections in Foals

Protective immune responses against Rhodococcus equi : an innate immunity-focused review

Rhodococcus equi–What is New This Decade?

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