Guinea Pig Vestibular Blood Flow in Response to Calcitonin-Gene Related Peptide

Burgio, Don L.; Hazra, A.; Komjathy, David A.; Quirk, Wayne S.

doi:10.3109/00016489709114207

Cited by 11 publications

(2 citation statements)

References 15 publications

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“…[4][5][6]. Infusion of 10 mg/ml pentoxifylline induced a decrease in BP of approximately 23% during the infusion period, which recovered less than 4 min following the infusion.…”

Section: Resultsmentioning

confidence: 99%

“…The test animal was then turned to a prone position and placed in a heated head holder. The right postauricular and occipital regions were infiltrated with local anesthesia to facilitate the surgical approach to the posterior semicircular [4,7]. The laser Doppler probe (Model ALF2100, Optokinetics Corp., Seattle, Wash.) mounted on a micromanipulator was then placed through the surgical opening and positioned on the posterior semicircular canal ampulla, just posterior to the round window niche.…”

Section: General Preparationsmentioning

confidence: 99%

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The effects of flunarizine and pentoxifylline on vestibular blood flow in the guinea pig

Doerr

Dziadziola

Komjathy

et al. 1998

European Archives of Oto-Rhino-Laryngology

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Several authors have proposed that complications arising from vestibular disorders are the result of compromised circulation. The purpose of the current study was to assess the ability of flunarizine and pentoxifylline to increase peripheral vestibular blood flow (VBF), since flunarizine is a selective calcium-channel entry blocker that inhibits calcium-related contraction of smooth muscle, while pentoxifylline is a xanthine derivative that promotes microcirculation by affecting red blood cell malleability. Both of these treatment strategies have received considerable attention in clinics and laboratory, but their effects on blood flow are unclear. Changes in VBF were evaluated from the posterior semicircular canal ampulla in guinea pigs using a laser Doppler flowmeter. One group of animals was infused with pentoxifylline at concentrations of 10-40 mg/ml, while a second group was treated with 0.3-1.5 mg/kg flunarizine. VBF, blood pressure (BP) and heart rate (HR) were monitored continuously. Findings showed that pentoxifylline induced a concentration-dependent increase in VBF. In contrast, no increase in VBF occurred in response to flunarizine infusions. These studies suggest that the effectiveness of pentoxifylline in the clinical treatment of vestibular disorders may be the result of improved blood flow.

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“…[4][5][6]. Infusion of 10 mg/ml pentoxifylline induced a decrease in BP of approximately 23% during the infusion period, which recovered less than 4 min following the infusion.…”

Section: Resultsmentioning

confidence: 99%

Section: General Preparationsmentioning

confidence: 99%

The effects of flunarizine and pentoxifylline on vestibular blood flow in the guinea pig

Doerr

Dziadziola

Komjathy

et al. 1998

European Archives of Oto-Rhino-Laryngology

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Local effects of nitric oxide on vestibular blood flow in the Mongolian gerbil

Arenberg

Komjathy

Seidman

et al. 1997

Eur Arch Otorhinolaryngol

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There is a paucity of studies regarding the regulation of vestibular blood flow (VBF), despite the possibility that vascular alterations may contribute to specific vestibulopathies. The current experiments used the Mongolian gerbil as an animal model since it provides easy surgical access to the vestibular end-organs and has been previously used for physiologic studies involving inner ear function. VBF changes were measured in the posterior semicircular canal using laser Doppler flowmetry following round window membrane (RWM) application of the nitric oxide donor 1, 3-propanediamine-N-[4-1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazi no] butyl (spermine NONOate; SPNO) as a vasodilator. The specificity of the responses induced was tested via pretreatment with an NO scavenger, 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazonline-1-oxyl-3-oxide (carboxy-PTIO; cPTIO). cPTIO, SPNO, vehicle (control) or cPTIO/SPNO were applied to the RWM, during which blood pressure and VBF were monitored for baseline, treatment, and recovery conditions. Results showed concentration-dependent increases in flow, probably resulting from NO's vasodilatory action on local vasculature. cPTIO pretreatment was found to attenuate SPNO-induced VBF increases. These findings support a role of NO in maintaining the vestibular microcirculation.

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