Guinea Worm Disease: A Neglected Diseases on the Verge of Eradication

Pellegrino, Carmen; Patti, Giulia; Camporeale, Michele; Belati, Alessandra; Novara, Roberta; Papagni, Roberta; Frallonardo, Luisa; Diella, Lucia; Guido, Giacomo; Vita, Elda De; Totaro, Valentina; Segala, Francesco Vladimiro; Veronese, Nicola; Cotugno, Sergio; Bavaro, Davide Fiore; Putoto, Giovanni; Bevilacqua, Nazario; Castellani, Chiara; Nicastri, Emanuele; Saracino, Annalisa; Gennaro, Francesco Di

doi:10.3390/tropicalmed7110366

Cited by 6 publications

(4 citation statements)

References 48 publications

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“…These radiological characteristics typically lead to an aetiological diagnosis. When the worm has partially decomposed and the calcifications are amorphous, diagnostic issues can arise [6][7][8]. Ectopic locations for calcified worms include the pericardium, orbit, and central nervous system [9].…”

Section: Discussionmentioning

confidence: 99%

Guinea Worm Disease Presenting as a Subcutaneous Calcification

Athavale,

Singh,

Tiwari

et al. 2024

Cureus

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Section: Discussionmentioning

confidence: 99%

Guinea Worm Disease Presenting as a Subcutaneous Calcification

Athavale,

Singh,

Tiwari

et al. 2024

Cureus

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“…Serology is of little use in the disease diagnosis, which remains mainly clinical [28]. Conventional PCR and nematode DNA amplification have been used to some extent, but the turnaround time from the sample reception to species confirmation can be up to two weeks.…”

Section: N Pathogenicity and Host-pathogen Interactionmentioning

confidence: 99%

“…This is a lengthy process that can take hours or days. One countermeasure is to squeeze the bump to free the adult worm from the carrying larvae making the parasite thinner and easier to remove [28]. There are no oral anthelmintic or effective drugs against dracunculiasis in humans.…”

Section: N the Obstacle Of Animal Reservoirs And Epidemiology Of Anim...mentioning

confidence: 99%

The current state of knowledge on dracunculiasis: a narrative review of a rare neglected disease

2023

Infez Med

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Dracunculiasis (Guinea Worm Disease) is a chronic disease that is primarily found in the arid and poor areas of our planet where water supply systems consist of open wells. This parasitic disease is transmitted to humans not only through the consumption of water contaminated with crustaceans harbouring larvae of Dracunculus medinensis, but also through the ingestion of paratenic (frogs) or transport hosts (fish). The natural progression of the disease is caused by adult worms invading connective tissues, leading to blistering and ulceration of the extremities, approximately one year after infection. In 1986, the Guinea Worm Eradication Program (GWEP) was launched and since then, the incidence of the disease has been reduced by over 99%. Indeed, the most recent global report from 2022 shows only 13 cases of human dracunculiasis worldwide, the lowest annual incidence ever reported. The new found knowledge of potential animal reservoirs and the recent discovery of possible edible paratenic hosts could pose challenges to the future eradication of this debilitating disease. Therefore, attempts to eradicate this parasitosis should not be postponed. Intensive research is needed in this neglected area of medicine, now that the goal is within reach.

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“…It is also a parasitic disease caused by the helminth Drancuncula medinensis, which is endemic in countries of Africa [14].…”

Section: Guinea Worm Disease (Gwd) or Dracunculiasismentioning

confidence: 99%

Impact of the Implementation of Sustainable Development Goals on Neglected Tropical Diseases

Fernandez Cerna,

F. Funes

2023

Sustainable Development

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Vector-borne diseases and infectious diseases in, general, affect the health of human and animal populations. By implementing the sustainable development goals (SDGs) in neglected populations, the level of living conditions is improved thus providing better housing, improving environments in cities and other populated sites, and developing better sanitary infrastructures altogether leading to higher-quality health conditions for the said populations. Transdisciplinary approaches can make successful implementation of the SDGs to tackle simultaneously the preservation and improvement of the environment, monitoring the health of human and animal populations, and studying in-depth those interactions in nature; those components are included in the One Health approach. Non-medicalized approaches can impact the roots of health problems, reducing the vulnerability of populations to disease, poverty, and malnutrition. Different initiatives of the SDGs can be effective in educating neglected populations to prevent exposure to vector arthropods, infectious agents, and undesired encounters with snakes and their disabling and life-threatening toxins. It will be important to actualize the implementation of the SDGs as a global strategy while also prioritizing each component.

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Guinea Worm Disease: A Neglected Diseases on the Verge of Eradication

Cited by 6 publications

References 48 publications

Guinea Worm Disease Presenting as a Subcutaneous Calcification

Guinea Worm Disease Presenting as a Subcutaneous Calcification

The current state of knowledge on dracunculiasis: a narrative review of a rare neglected disease

Impact of the Implementation of Sustainable Development Goals on Neglected Tropical Diseases

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