Gum based 3D composite scaffolds for bone tissue engineering applications

Anandan, Dhivyaa; Madhumathi, G.; Nambiraj, N. Arunai; Jaiswal, Akhilesh

doi:10.1016/j.carbpol.2019.03.020

Cited by 35 publications

(12 citation statements)

References 37 publications

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“…Anandan et al studied the effect of adding HaP to a gum-based scaffold. Results showed that addition of HaP was porous with increased scaffold mechanical strength and capable of inhibiting nutrients, water, other essential materials required for cell and tissue growth . Selective layer sintering (SLS) developed PLLA and 2-carboxyethylphosphonic acid (CEPA) treated HaP scaffolds were also reported.…”

Section: Materials Involvedmentioning

confidence: 99%

“…Results showed that addition of HaP was porous with increased scaffold mechanical strength and capable of inhibiting nutrients, water, other essential materials required for cell and tissue growth. 79 Selective layer sintering (SLS) developed PLLA and 2-carboxyethylphosphonic acid (CEPA) treated HaP scaffolds were also reported. It has also been reported that even distribution of HaP nanoparticles in the PLLA matrix was achieved upon modifying HaP with CEPA.…”

Section: Materials Involvedmentioning

confidence: 99%

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Comprehensive Review on Design and Manufacturing of Bio-scaffolds for Bone Reconstruction

Ravoor

Thangavel

Elsen

2021

ACS Appl. Bio Mater.

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Bio-scaffolds are synthetic entities widely employed in bone and soft-tissue regeneration applications. These bio-scaffolds are applied to the defect site to provide support and favor cell attachment and growth, thereby enhancing the regeneration of the defective site. The progressive research in bio-scaffold fabrication has led to identification of biocompatible and mechanically stable materials. The difficulties in obtaining grafts and expenditure incurred in the transplantation procedures have also been overcome by the implantation of bio-scaffolds. Drugs, cells, growth factors, and biomolecules can be embedded with bio-scaffolds to provide localized treatments. The right choice of materials and fabrication approaches can help in developing bio-scaffolds with required properties. This review mostly focuses on the available materials and bio-scaffold techniques for bone and soft-tissue regeneration application. The first part of this review gives insight into the various classes of biomaterials involved in bio-scaffold fabrication followed by design and simulation techniques. The latter discusses the various additive, subtractive, hybrid, and other improved techniques involved in the development of bio-scaffolds for bone regeneration applications. Techniques involving multimaterial printing and multidimensional printing have also been briefly discussed.

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Section: Materials Involvedmentioning

confidence: 99%

Section: Materials Involvedmentioning

confidence: 99%

Comprehensive Review on Design and Manufacturing of Bio-scaffolds for Bone Reconstruction

Ravoor

Thangavel

Elsen

2021

ACS Appl. Bio Mater.

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“…69 In the current study, mouse fibroblast L929 cells and rat chondrocytes were widely used to measure the cytotoxicity of osteoarthritis treatment products. 70,71 Therefore, we selected mouse fibroblast L929 cells and rat chondrocytes as cell models for cytotoxicity testing in the articular cavity. L929 cells are chosen to simulate synovial fibroblasts in a direct culture system, while chondrocytes are cultured in a Transwell system because chondrocytes are always embedded in the cartilage matrix, which is not in touch with joint fluid directly (Fig.…”

Section: Cell Cytotoxicitymentioning

confidence: 99%

Gellan gum modified hyaluronic acid hydrogels as viscosupplements with lubrication maintenance and enzymatic resistance

Chen

Xing

et al. 2022

J. Mater. Chem. B

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“…In another study, guar gum was used together with konjac glucomannan to improve the inferior anti-washout property of injectable calcium phosphate cement [ 24 ]. As a gel-forming galactomannan, GG was mixed with gellan gum and hydroxyapatite, crosslinked with sodium trimetaphosphate, finally becoming obtainable in 3D freeze-dried scaffolds suitable for bone tissue engineering applications [ 25 ]. In a significant study published by Senthilarasan et al, the authors highlighted the antibacterial and anti-inflammatory activity of nano-hydroxyapatite/GG composites [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Polysaccharides-Calcium Phosphates Composite Beads as Bone Substitutes for Fractures Repair and Regeneration

et al. 2023

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The tendency of population aging is continuously increasing, which is directly correlated with a significative number of associated pathologies. Several metabolic bone diseases such as osteoporosis or chronic kidney disease–mineral and bone disorders involve a high risk of fractures. Due to the specific fragility, bones will not self-heal and supportive treatments are necessary. Implantable bone substitutes, a component of bone tissue engineering (BTE) strategy, proved to be an efficient solution for this issue. The aim of this study was to develop composites beads (CBs) with application in the complex field of BTE, by assembling the features of both biomaterials’ classes: biopolymers (more specific, polysaccharides: alginate and two different concentrations of guar gum/carboxymethyl guar gum) and ceramics (more specific, calcium phosphates), in a combination described for the first time in the literature. The CBs prepared by double crosslinking (ionic and physically) showed adequate physico-chemical characteristics and capabilities (morphology, chemical structure and composition, mechanical strength, and in vitro behaviour in four different acellular simulated body fluids) for bone tissue repair. Moreover, preliminary in vitro studies on cell cultures highlighted that the CBs were free of cytotoxicity and did not affect the morphology and density of cells. The results indicated that the beads based on a higher concentration of guar gum have superior properties than those with carboxymetilated guar, especially in terms of mechanical properties and behaviour in simulated body fluids.

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Gum based 3D composite scaffolds for bone tissue engineering applications

Cited by 35 publications

References 37 publications

Comprehensive Review on Design and Manufacturing of Bio-scaffolds for Bone Reconstruction

Comprehensive Review on Design and Manufacturing of Bio-scaffolds for Bone Reconstruction

Gellan gum modified hyaluronic acid hydrogels as viscosupplements with lubrication maintenance and enzymatic resistance

Polysaccharides-Calcium Phosphates Composite Beads as Bone Substitutes for Fractures Repair and Regeneration

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