Gum ghatti mediated, one pot green synthesis of optimized gold nanoparticles: Investigation of process-variables impact using Box-Behnken based statistical design

Alam, Md Sabir; Garg, Arun; Pottoo, Faheem Hyder; Saifullah, Mohammad Khalid; Tareq, Abu Izneid; Manzoor, Ovais; Mohsin, Mohd; Javed, Nazir

doi:10.1016/j.ijbiomac.2017.05.129

Cited by 58 publications

(35 citation statements)

References 9 publications

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“…Presence of significant curvature in responses 3‐D‐Response surface graph (Figure and Figure ) established impact and effects of Quadratic terms i.e., their contribution towards the final responses while overlapping the performance area of individual factors of each response optimized levels of each factor . In ANOVA analysis, impact of significant model terms were expressed as coefficients, positive coefficients terms favouring the response, while negative term inversely related to the response, to generate polynomial mathematical equations which determined Hydrodynamic size, PDI and zeta potential …”

Section: Resultsmentioning

confidence: 99%

“…Preformulation studies of microwave assisted synthesis of gold nanoparticles suggested that water insoluble or water swellable gums such as gum Karaya, gum Xanthan, and gum Tragacanth may possess improper mixing of reactants and adversely affects mobility of synthesized nanoparticles . Hence, these nanoparticles of undesired attributes with significant variations due to high bias and errors terms, in their performances characteristics; hence limiting industrial suitability .…”

Section: Discussionmentioning

confidence: 99%

“…Here, stock gum solution (2–4 ml) and 0.1 M gold solution (20–40 μL) were selected as CPPs (Critical process parameters) while, at power of 490 (70% of 700) watts of microwave the reaction cut‐off temperature (70–90 °C) was selected as CMA (critical material attributes) …”

Section: Methodsmentioning

confidence: 99%

“…Here, Y refers to CQAs (hydrodynamic size, PDI and zeta potential), k refers to number of independent variables (volume of gum, volume of gold and temperature), while β signifies regression coefficient, ℇ signifies residual error, X ı signifies real and dimensionless value of independent variables, X 0 signifies central point of independent variables and Δ X ı is steep change value. Furthermore, different set of ANOVA type‐I and type‐III statistical tests, and their parameters such as p‐value and f‐value (test of significance), were estimated to signify contribution of independent variables in terms of variance . Furthermore, polynomial mathematical relationship with coefficients of main and interactions effect, were established based on significance values of p and F test…”

Section: Methodsmentioning

confidence: 99%

“…So, in above perspective; one step and one pot microwave assisted and industrial applicable facile synthesis process were investigated to green synthesis of gold nanoparticles using GRAS (Generally‐regarded‐as‐safe) enlisted Anogeissus latifolia i.e., gum Ghatti (USFDA Food Code:184.1333) biopolymer; owing to presence of desired aldehyde functional groups as well as its well established role as stabilizer in emulsions, suspensions and syrups …”

Section: Introductionmentioning

confidence: 99%

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QbD approached comparison of reaction mechanism in microwave synthesized gold nanoparticles and their superior catalytic role against hazardous nirto‐dye

Alam

Javed

Pottoo

et al. 2019

Applied Organom Chemis

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Microwave irradiation (MI) process characteristically enables extremely rapid “in‐core” heating of dipoles and ions, in comparison to conventional thermal (conductance) process of heat transfer. During the process of nanoparticles synthesis, MI both modulates functionality behaviors as well as dynamic of reaction in favorable direction. So, MI providing a facile, favorable and alternative approach during nanoparticles synthesis nanoparticles with enhanced catalytic performances. Although, conventionally used reducing and capping reagents of synthetic origin, are usually environmentally hazardous and toxic for living organism. But, in absence of suitable capping agent; stability, shelf life and catalytic activity of metallic nanoparticles adversely affected. However, polymeric templates which emerged as suitable choice of agent for both reducing and capping purposes; bearing additional advantages in terms of catalyst free one step green synthesis process with high degree of biosafety and efficiency. Another aspect of current works was to understand role of process variables in growth mechanism and catalytic performances of microwave processed metallic nanoparticles, as well as comparison of these parameters with conventional heating method. However, due to poor prediction ability with previously published architect OFAT (One factor at a time) design with these nanoparticles as well as random selection of process variables with their different levels, such comparison couldn't be possible. Hence, using gum Ghatti (Anogeissus latifolia) as a model bio‐template and under simulated reaction conditions; architect of QbD design systems were integrated in microwave processed nanoparticles to establish mechanistic role these variables. Furthermore, in comparison to conventional heating; we reported well validated mathematical modeling of process variables on characteristic of nanoparticles as well as synthesized gold nanoparticles of desired and identical dimensions, in both thermal and microwave‐based processes. Interestingly, despite of identical dimension, MI processed gold nanoparticles bearing higher efficiency (kinetic rate) against remediation of hazardous nitro dye (4‐nitrophenol), into safer amino (4‐aminophenol) analogues.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

QbD approached comparison of reaction mechanism in microwave synthesized gold nanoparticles and their superior catalytic role against hazardous nirto‐dye

Alam

Javed

Pottoo

et al. 2019

Applied Organom Chemis

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Plant and Tree Gums as Renewable Feedstocks for the Phytosynthesis of Nanoparticles: A Green Chemistry Approach

Kora

2018

Green Metal Nanoparticles

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Injectable sustained‐release poly(lactic‐co‐glycolic acid) (PLGA) microspheres of exenatide prepared by supercritical fluid extraction of emulsion process based on a design of experiment approach

Park

Kim

et al. 2023

Bioengineering & Transla Med

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This study aimed to develop an improved sustained‐release (SR) PLGA microsphere of exenatide using supercritical fluid extraction of emulsions (SFEE). As a translational research, we investigated the effect of various process parameters on the fabrication of exenatide‐loaded PLGA microspheres by SFEE (ELPM_SFEE) using the Box–Behnken design (BBD), a design of experiment approach. Further, ELPM obtained under optimized conditions and satisfying all the response criteria were compared with PLGA microspheres prepared using the conventional solvent evaporation (ELPM_SE) method through various solid‐state characterizations and in vitro and in vivo evaluations. The four process parameters selected as independent variables were pressure (X1), temperature (X2), stirring rate (X3), and flow ratio (X4). The effects of these independent variables on five responses, namely the particle size, its distribution (SPAN value), encapsulation efficiency (EE), initial drug burst release (IBR), and residual organic solvent, were evaluated using BBD. Based on the experimental results, a desirable range of combinations of various variables in the SFEE process was determined by graphical optimization. Solid‐state characterization and in vitro evaluation revealed that ELPM_SFEE improved properties, including a smaller particle size and SPAN value, higher EE, lower IBR, and lower residual solvent. Furthermore, the pharmacokinetic and pharmacodynamic study results indicated better in vivo efficacy with desirable SR properties, including a reduction in blood glucose levels, weight gain, and food intake, for ELPM_SFEE than those generated using SE. Therefore, the potential drawback of conventional technologies such as the SE for the preparation of injectable SR PLGA microspheres could be improved by optimizing the SFEE process.

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Gum ghatti mediated, one pot green synthesis of optimized gold nanoparticles: Investigation of process-variables impact using Box-Behnken based statistical design

Cited by 58 publications

References 9 publications

QbD approached comparison of reaction mechanism in microwave synthesized gold nanoparticles and their superior catalytic role against hazardous nirto‐dye

QbD approached comparison of reaction mechanism in microwave synthesized gold nanoparticles and their superior catalytic role against hazardous nirto‐dye

Plant and Tree Gums as Renewable Feedstocks for the Phytosynthesis of Nanoparticles: A Green Chemistry Approach

Injectable sustained‐release poly(lactic‐co‐glycolic acid) (PLGA) microspheres of exenatide prepared by supercritical fluid extraction of emulsion process based on a design of experiment approach

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