Gummatous lesions in men infected with human immunodeficiency virus and syphilis.

Hay, Phillip; Tam, Frederick W.K.; Kitchen, V. S.; Horner, Stacy M.; Bridger, Janice C.; Weber, J

doi:10.1136/sti.66.5.374

Cited by 14 publications

(18 citation statements)

References 24 publications

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“…Numerous case reports indicate that syphilis can present in highly atypical and aggressive forms in HIV-positive persons; however, the frequency of such atypical presentations is unclear. HIV-positive patients with syphilis may be more likely than HIV-negative persons to present with persistent chancres [12], ulcerative skin lesions [13,14], gummatous disease [15,16], and early ocular involvement [17]. In a prospective study that included 101 HIV-positive and 440 HIV-negative patients with syphilis, Rolfs et al [18] noted that HIV-positive patients were more likely to have multiple chancres and to experience Jarisch-Herxheimer reactions than were HIV-negative patients (22% vs. 12%, respectively;…”

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confidence: 99%

The Clinical Manifestations and Treatment of Sexually Transmitted Diseases in Human Immunodeficiency Virus-Positive Men

Collis

Celum

2001

Clinical Infectious Diseases

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Sexually transmitted diseases (STDs) occur commonly in sexually active human immunodeficiency virus (HIV)-positive men. STDs may have atypical presentations, can cause significant morbidity in persons with HIV infection, and may increase the risk of HIV transmission. Thus, the appropriate diagnosis and treatment of STDs in this population are extremely important. The clinical manifestations and treatment of several common STDs in HIV-positive men are reviewed. Further research is needed to define effective management and screening strategies for STDs in men with HIV infection.

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confidence: 99%

The Clinical Manifestations and Treatment of Sexually Transmitted Diseases in Human Immunodeficiency Virus-Positive Men

Collis

Celum

2001

Clinical Infectious Diseases

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“…The formation of gumma may be because of a hypersensitivity reaction caused either by a reactivation of infection with T. pallidum or by reinfection. 11 The pathogenic mechanism is delayed allergy induced by some antigen of T. pallidum, which is related to cell-mediated immune response. 12 Despite the prolonged alteration of the immune response in HIV-positive patient, gumma can still form.…”

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confidence: 99%

Cerebral Syphilitic Gumma Mimicking Glioblastoma

Wang

Zhang

Zhao

2016

Neurosurgery Quarterly

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A case of suspected glioblastoma accompanied by systemic syphilis was referred to our institute for surgery. She was a 47-year-old woman presenting with headache and vomiting. A frontal mass with ring enhancement and surrounding edema was revealed by MRI. Although neurosyphilis was considered a differential diagnosis, surgery was performed and cerebral syphilitic gumma was confirmed by histology. To reduce misdiagnosis, we reviewed the related literature and summarized pathogenesis, radiologic features, and treatment strategy of cerebral syphilitic gumma.

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“…In einigen Fällen traten Gummen und tuberoserpiginöse Syphilide sogar gleichzeitig mit den makulopapulösen Syphiliden der Sekundärsyphilis auf [1,5]. Hay et al [10] beobachteten die Entwicklung von Gummen 12 Monate nach einer adäquaten Syphilistherapie und ohne Veränderungen des posttherapeutischen VDRL-Titers.Bei mehreren HIV-Infizierten wurden zerebrale Gummen als Ursache einer Schlaganfallsymptomatik festgestellt [2].…”

Section: Syphilis Iii: Besonderheiten Bei Zellulärer Immundefizienz Uunclassified

Syphilis

Schöfer

2004

Der Hautarzt

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Syphilis is a sexually transmitted infection by Treponema pallidum. Without antibiotic treatment syphilis lasts for several decades and may develop up to 4 different clinical stages. Usually, the disease begins with a distinct painless and indurated ulcer at the contact site: the primary chancre. An indolent regional lymph node swelling is usually associated with the syphilitic chancre. After spontaneous healing of the primary lesion and several weeks of latency, the clinical symptoms of secondary syphilis occur. Treponema pallidum bacteremia leads to common symptoms like fever and malaise, but also to a generalized lymphadenopathy, and a broad variety of lesions of the skin and mucosal membranes. Non-pruritic transient exanthems often involving palms and soles, condylomata lata, and a specific angina with mucous patches of the oral cavity are prominent signs. After several relapses, which are characterized by a decreasing intensity of clinical symptoms, secondary syphilis then resolves spontaneously. A second period of latency follows, lasting 3-12 years. Then the outcome of untreated syphilis becomes apparent: spontaneous healing by elimination/inactivation of the spirochetes (75%) or transition to tertiary syphilis (25%). Two kinds of granulomatous skin reactions are typical for tertiary syphilis: superficial nodular syphilids and gummas. The bones, as well as the cardiovascular and central nervous system, may also be involved. Finally, metasyphilis with severe and sometimes lethal neurological symptoms (tabes dorsalis, progressive paralysis) occurs 10 to 30 years after primary infection. Except for irreversible tissue destruction which occurs prior to therapy, all stages of syphilis can be cured completely.

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Gummatous lesions in men infected with human immunodeficiency virus and syphilis.

Cited by 14 publications

References 24 publications

The Clinical Manifestations and Treatment of Sexually Transmitted Diseases in Human Immunodeficiency Virus-Positive Men

The Clinical Manifestations and Treatment of Sexually Transmitted Diseases in Human Immunodeficiency Virus-Positive Men

Cerebral Syphilitic Gumma Mimicking Glioblastoma

Syphilis

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