Gums as Pharmaceutical Excipients: An Overview

Muruganantham, S.; Krishnaswami, Venkateshwaran; AnithaManikandan, D.; Aravindaraj, Nirmal; Suresh, Jeseeta; Murugesan, Mohanraj; Kandasamy, Ruckmani

doi:10.1007/978-3-030-76523-1_7-1

Cited by 1 publication

(1 citation statement)

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“…Among these systems, matrix tablet formulations have emerged as a promising strategy for achieving controlled drug release. [1] Such formulations provide a stable platform to regulate the release of therapeutic agents, optimizing their efficacy and patient compliance. Albizia procera, sourced as an exudate from the Albizia tree belonging to the Mimosaceae family, serves as a carbohydrate polymer.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Effectiveness of Carboxymethylated and Crosslinked <i>Albizia procera</i> Gum in Diltiazem Hydrochloride Matrix Tablets: A Comparative Analysis

Mukherjee,

Khanam

2024

CHEMICAL & PHARMACEUTICAL BULLETIN

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This study investigates the efficacy of modified Albizia procera gum as a release-retardant polymer in Diltiazem hydrochloride (DIL) matrix tablets. Carboxymethylated Albizia procera gum (CAP) and ionically crosslinked carboxymethylated Albizia procera gum (Ca-CAP) were utilized, with Ca-CAP synthesized via crosslinking CAP with calcium ions (Ca²⁺) using calcium chloride (CaCl2). FTIR analysis affirmed polymer compatibility, while Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) assessed thermal behavior and crystallinity, respectively. Zeta potential analysis explored surface charge and electrostatic interactions, while rheology examined flow and viscoelastic properties. Swelling and erosion kinetics provided insights into water penetration and stability. CAP's carboxymethyl groups (-CH2-COO -) heightened divalent cation reactivity, and crosslinking with CaCl2 produced Ca-CAP through -CH2-COOand Ca²⁺ interactions. Structural similarities between the polymers were revealed by FTIR, with slight differences. DSC indicated modified thermal behavior in Ca-CAP, while Zeta potential analysis showcased negative charges, with Ca-CAP exhibiting lower negativity. XRD highlighted increased crystallinity in Ca-CAP due to calcium crosslinking. Minimal impact on RBC properties was observed with both polymers compared to the positive control as water for injection (WFI). Ca-CAP exhibited improved viscosity, strength, controlled swelling, and erosion, allowing prolonged drug release compared to CAP. Stability studies confirmed consistent six-month drug release, emphasizing Ca-CAP's potential as a stable, sustained drug delivery system over CAP. Robustness and accelerated stability tests supported these findings, underscoring the promise of Ca-CAP in controlled drug release applications.

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Section: Introductionmentioning

confidence: 99%