Gustatory preference-aversion profiles for saccharin, quinine and alcohol in Roman high- and low-avoidance lines

Razafimanalina, Raharinoro; Mormède, Pierre; Velley, Lydia

doi:10.1097/00008877-199601000-00008

Cited by 40 publications

(19 citation statements)

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“…In keeping with this hypothesis, reinstatement of drugseeking behavior following non-contingent cocaine injections was more robust in RHA than RLA rats. Intriguingly, previous studies on ethanol and saccharin intake using a two-bottle free choice paradigm have shown that, compared with RLA rats, RHA rats display a higher preference for both ethanol and saccharin solutions over water (Razafimanalina et al, 1996;Fernández-Teruel et al, 2002). These findings suggest that the line-related differences in the responsiveness to cocaine SA observed in the present study may also extend to the voluntary intake of other drugs of abuse or natural reinforcers, although further studies are required to establish whether the line-related behavioral differences reported herein indeed reflect a higher motivation for cocaine in RHA vs RLA rats.…”

Section: Figurementioning

confidence: 82%

The Roman High- and Low-Avoidance Rat Lines Differ in the Acquisition, Maintenance, Extinction, and Reinstatement of Intravenous Cocaine Self-Administration

Fattore

Piras

Corda

et al. 2008

Neuropsychopharmacol

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The selective breeding of Roman high-(RHA) and low-avoidance (RLA) rats for, respectively, rapid vs extremely poor acquisition of avoidant behavior in a shuttlebox has produced two phenotypes that differ in temperament traits, in mesocortical/mesolimbic dopamine system function, and in the behavioral and neurochemical responses to the acute and repeated administration of psychostimulants and opiates. The phenotypic traits of the RHA line predict higher susceptibility, compared with RLA rats, to the reinforcing properties of addictive substances like cocaine. The present study was designed to compare the acquisition, maintenance, reinstatement of drugseeking after long-term extinction, and reacquisition of intravenous cocaine self-administration (SA) behavior in the Roman lines. Compared with RLA rats, the rates of responding during cocaine SA acquisition were higher, extinction from cocaine SA was prolonged, and drug-induced reinstatement of cocaine-seeking behavior was more robust in RHA rats. Moreover, only RHA rats reacquired extinguished lever-pressing activity when a low reinforcing dose of cocaine was available. These findings are consistent with the view that subjects with genetically determined high responsiveness to the acute and chronic (ie, sensitizing) effects of psychostimulants, such as RHA rats, also display a higher propensity to self -administer cocaine. Further comparative studies in the Roman lines, using SA paradigms that distinguish mere drug-taking from the compulsive and uncontrolled drug use that characterizes addiction in humans, may eventually help to characterize the relationships among genotype, temperament traits, and neurobiological mechanisms involved in the individual vulnerability to cocaine addiction.

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Section: Figurementioning

confidence: 82%

The Roman High- and Low-Avoidance Rat Lines Differ in the Acquisition, Maintenance, Extinction, and Reinstatement of Intravenous Cocaine Self-Administration

Fattore

Piras

Corda

et al. 2008

Neuropsychopharmacol

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“…RHA rats show higher levels of exploratory behavior in tests of novelty seeking when compared to RLA rats (Escorihuela et al 1999;Fernández-Teruel et al 1997Guitart-Masip et al 2006a). Concerning animal models of divergent vulnerability to drug addiction, RHA rats have so far shown enhanced preference for alcohol and other rewarding substances (Razafimanalina et al 1996;Corda et al 2001;Fernández-Teruel et al 2002), as well as greater behavioral sensitization to morphine (Piras et al 2003), cocaine (Giorgi et al 2005b), and amphetamine (Corda et al 2005;Giorgi et al 2005a) when compared to RLA rats. We recently showed that RHA-I rats show higher D 3 receptor binding in the shell of the nucleus accumbens than RLA-I rats, whereas rats of the latter strain show higher D 3 binding in the Calleja Islands than RHA rats (Guitart-Masip et al 2006b).…”

Section: Introductionmentioning

confidence: 99%

Divergent effect of the selective D3 receptor agonist pd-128,907 on locomotor activity in Roman high- and low-avoidance rats: relationship to NGFI-A gene expression in the Calleja islands

et al. 2007

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“…In this regard, the sublines of Roman high‐ (RHA) and low‐avoidance (RLA) rats, psychogenetically selected for, respectively, rapid vs. extremely poor two‐way active avoidance acquisition (Driscoll & Bättig, 1982), appear to be a valid laboratory model of divergent novelty‐ and substance‐seeking profiles , as well as of differential central DAergic activity in a wide range of experimental situations (reviewed by Driscoll et al ., 1998). Thus, compared with RLA/Verh rats, RHA/Verh rats show: (i) higher levels of exploratory behaviour in tests of novelty seeking (Fernández‐Teruel et al ., 1992, 1997a, 2002; Escorihuela et al ., 1999); (ii) higher preference for alcohol (Driscoll et al ., 1990; Razafimanalina et al ., 1996; Corda et al ., 2001), as well as saccharin and quinine solutions (Razafimanalina et al ., 1996; Fernández‐Teruel et al ., 2002); (iii) stronger mesocortical and mesolimbic dopaminergic responses to, respectively, stress (D'Angio et al ., 1988; Giorgi et al ., 2003) and addictive substances, including EtOH (Giorgi et al ., 1997, 2005; Corda et al ., 2001). Moreover, RHA/Verh rats are less sensitive than RLA/Verh rats to the hypnotic effects of alcohol (Fernández‐Teruel et al ., 1997b).…”

Section: Introductionmentioning

confidence: 99%

Reduced ethanol response in the alcohol‐preferring RHA rats and neuropeptide mRNAs in relevant structures

Guitart-Masip

Fernández-Teruel

Cañete

et al. 2006

Eur J of Neuroscience

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Roman rat strains, genetically selected for high (RHA) or low (RLA) active avoidance acquisition in the two-way shuttle box, differ in dopaminergic activity. These two strains appear to be a valid laboratory model of divergent sensation/novelty and substance-seeking profiles. RHA rats show higher ethanol intake and preference than do RLA rats, and it was suggested that RHA rats are more tolerant than RLA to the effects of alcohol. In the hole-board test, we found that the non-alcohol-preferring RLA rats showed enhanced responsiveness to the stimulatory effects of intraperitoneal administration of 0.25 g/kg ethanol when compared with RHA rats. In situ hybridization analysis showed higher levels of preprodynorphin in the accumbens shell and higher levels of preproenkephalin in the cingulate cortex in RHA rats. RLA rats showed higher levels of enkephalin gene transcripts in restricted areas of the dorsal striatum. Finally, differences in cholecystokinin gene transcript, suggestive of a different arrangement of certain interneurons, were found in different cortical areas. The differences in peptide gene expression found between the two strains might reflect the differences in alcohol preference and sensitivity. RHA rats may have more predictive value than other rodent alcoholism models, as high initial tolerance to ethanol is a risk factor for alcoholism in humans.

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Gustatory preference-aversion profiles for saccharin, quinine and alcohol in Roman high- and low-avoidance lines

Cited by 40 publications

References 0 publications

The Roman High- and Low-Avoidance Rat Lines Differ in the Acquisition, Maintenance, Extinction, and Reinstatement of Intravenous Cocaine Self-Administration

The Roman High- and Low-Avoidance Rat Lines Differ in the Acquisition, Maintenance, Extinction, and Reinstatement of Intravenous Cocaine Self-Administration

Divergent effect of the selective D3 receptor agonist pd-128,907 on locomotor activity in Roman high- and low-avoidance rats: relationship to NGFI-A gene expression in the Calleja islands

Reduced ethanol response in the alcohol‐preferring RHA rats and neuropeptide mRNAs in relevant structures

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