Gut bacteria-derived 3-phenylpropionylglycine mitigates adipocyte differentiation of 3T3-L1 cells by inhibiting adiponectin-PPAR pathway

Jung, Hae Rim; Oh, Yumi; Jang, Dongjun; Shin, Seungjae; Lee, Soo Jin; Kim, Jiwon; Lee, Sang Eun; Oh, Jaeik; Jang, Giyong; Kwon, Obin; Lee, Yeonmi; Lee, Hui Young; Cho, Sung-Yup

doi:10.1007/s13258-022-01332-y

Genes Genom

2022

DOI: 10.1007/s13258-022-01332-y

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Gut bacteria-derived 3-phenylpropionylglycine mitigates adipocyte differentiation of 3T3-L1 cells by inhibiting adiponectin-PPAR pathway

Hae Rim Jung

Yumi Oh

Dongjun Jang

et al.

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2024

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Ionizing Radiation Dose Differentially Affects the Host–Microbe Relationship over Time

Chakraborty,

Hoke,

Campbell

et al. 2024

Microorganisms

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Microorganisms that colonize in or on a host play significant roles in regulating the host’s immunological fitness and bioenergy production, thus controlling the host’s stress responses. Radiation elicits a pro-inflammatory and bioenergy-expensive state, which could influence the gut microbial compositions and, therefore, the host–microbe bidirectional relationship. To test this hypothesis, young adult mice were exposed to total body irradiation (TBI) at doses of 9.5 Gy and 11 Gy, respectively. The irradiated mice were euthanized on days 1, 3, and 9 post TBI, and their descending colon contents (DCCs) were collected. The 16S ribosomal RNAs from the DCCs were screened to find the differentially enriched bacterial taxa due to TBI. Subsequently, these data were analyzed to identify the metagenome-specific biofunctions. The bacterial community of the DCCs showed increased levels of diversity as time progressed following TBI. The abundance profile was the most divergent at day 9 post 11 Gy TBI. For instance, an anti-inflammatory and energy-harvesting bacterium, namely, Firmicutes, became highly abundant and co-expressed in the DCC with pro-inflammatory Deferribacteres at day 9 post 11 Gy TBI. A systems evaluation found a diverging trend in the regulation profiles of the functional networks that were linked to the bacteria and metabolites of the DCCs, respectively. Additionally, the network clusters associated with lipid metabolism and bioenergy synthesis were found to be activated in the DCC bacteria but inhibited in the metabolite space at day 9 post 11 Gy. Taking these results together, the present analysis indicated a disrupted mouse–bacteria symbiotic relationship as time progressed after lethal irradiation. This information can help develop precise interventions to ameliorate the symptoms triggered by TBI.

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Ionizing Radiation Dose Differentially Affects the Host–Microbe Relationship over Time

Chakraborty,

Hoke,

Campbell

et al. 2024

Microorganisms

View full text Add to dashboard Cite

show abstract

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Gut bacteria-derived 3-phenylpropionylglycine mitigates adipocyte differentiation of 3T3-L1 cells by inhibiting adiponectin-PPAR pathway

Cited by 1 publication

References 40 publications

Ionizing Radiation Dose Differentially Affects the Host–Microbe Relationship over Time

Ionizing Radiation Dose Differentially Affects the Host–Microbe Relationship over Time

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