Neurodegenerative disorders (NDDs) are multifaceted complex disorders that have put a
great health and economic burden around the globe nowadays. The multi-factorial nature of
NDDs has presented a great challenge in drug discovery and continuous efforts are in
progress in search of suitable therapeutic candidates. Nature has a great wealth of active
principles in its lap that has cured the human population since ancient times. Natural products
have revealed several benefits over conventional synthetic medications and scientists have
shifted their vision towards exploring the therapeutic potentials of natural products in the past
few years. The structural mimicking of natural compounds to endogenous ligands has
presented them as a potential therapeutic candidate to prevent the development of NDDs. In
the presented review, authors have summarized demographical facts about various NDDs
including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD)
and various types of sclerosis in the brain. The significant findings of new active principles of
natural origin along with their therapeutic potentials on NDDs have been included. Also, a
description of clinical trials and patents on natural products has been enlisted in this
compilation. Although natural products have shown promising success in drug discovery
against NDDs, still their use is associated with several ethical issues which need to be solved
in the upcoming time.