Gut Bacterial Dysbiosis in Irritable Bowel Syndrome: a Case-Control Study and a Cross-Cohort Analysis Using Publicly Available Data Sets

Kim, Gun Ha; Lee, Kihyun; Shim, Jung Ok

doi:10.1128/spectrum.02125-22

Cited by 12 publications

(12 citation statements)

References 28 publications

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“…87 Interestingly, changes in structure and composition of gut microflora occur irrespective of insulin resistance in people with PCOS, 88 contributing to the manifestations of hyperandrogenism, insulin resistance, chronic inflammation, and abnormal levels of brain-gut peptides. [89][90][91] As dysbiosis is associated with irritable bowel syndrome (IBS), 92 and IBS is reported to impact the quality of life in 21 to 27% of those diagnosed with PCOS, 93 focusing on interventions to treat dysbiosis through prebiotics, probiotics, and synbiotics is an important part of PCOS nutritional care. Probiotics are thought to stabilize the hormonal imbalance through the gut-brain axis, leading to a reduction in the LH/FSH ratio in PCOS populations.…”

Section: Lifestyle Intervention: Important With or Without Medical Th...mentioning

confidence: 99%

Diet and Exercise in the Management of Polycystic Ovary Syndrome: Practical Considerations for Person-Centered Care

Colombo,

Pirotta,

Sabag

2023

Semin Reprod Med

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Polycystic ovary syndrome (PCOS) is a complex multisystem condition associated with life-long reproductive, metabolic, and psychological symptoms. Individuals with PCOS are at an increased risk of cardiovascular disease and type 2 diabetes, with approximately 70% of all PCOS cases presenting with insulin resistance. Lifestyle interventions have historically been recommended as first-line therapies for the management of PCOS-related cardiometabolic disorders. The term “lifestyle management” incorporates a multifaceted approach to dietary, exercise, and behavioral strategies, aiming to promote a healthy lifestyle. This approach has been commonly employed in practice, in particular through exercise and dietary modulation, due to its effect on cardiometabolic outcomes as well as its tolerability. Furthermore, there is evidence to suggest that combining dietary change with exercise may yield the greatest improvements in clinical outcomes. However, such practices require careful consideration and coordination, as there are instances where certain exercise and/or dietary prescriptions may compromise the effectiveness of the respective interventions. Thus, this review aims to provide practical guidance on diet and exercise planning in the routine care of PCOS. Such recommendations include emphasizing realistic and achievable goals, as well as minimizing barriers to lifestyle changes in order to increase the long-term sustainability of this treatment strategy.

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Section: Lifestyle Intervention: Important With or Without Medical Th...mentioning

confidence: 99%

Diet and Exercise in the Management of Polycystic Ovary Syndrome: Practical Considerations for Person-Centered Care

Colombo,

Pirotta,

Sabag

2023

Semin Reprod Med

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“…However, a more recent review of 16 studies focusing on longitudinal omics studies only, showed significant heterogeneity across gut microbial characteristics in IBS cohorts across studies, concluding that defining uniform gut microbial characteristics of an IBS-related gut microbiota is challenging (Ng et al, 2023). However, while clearer characterisation of IBS-related gut microbial characteristics is needed, overall, gut microbial dysbiosis is prevalent in this cohort (Wang et al, 2020; Kim et al, 2023; Ng et al, 2023). In IBD patients, a recent meta-analysis of 13 studies showed faecal bacterial alpha diversity was lower compared to healthy controls, and this was more pronounced in CD compared to UC (Abdel-Rahman and Morgan, 2022).…”

Section: Introductionmentioning

confidence: 96%

“…While the pathogenesis of FGIDs and IBD is complex, gut microbial dysbiosis appears to be intertwined with such gastrointestinal diseases and disorders (Xavier and Podolsky, 2007; Holtmann et al, 2016). In comparison to healthy individuals, FGID and IBD cohorts have been shown to have different gut microbial characteristics (Duan et al, 2019; Pittayanon et al, 2020; Wang et al, 2020; Clooney et al, 2021; Abdel-Rahman and Morgan, 2022; Kim et al, 2023). A 2019 systematic review of 16 studies showed IBS patients had lower faecal bacterial alpha diversity, compared to healthy controls (Duan et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Similarly to studies in IBS cohorts, studies comparing gut microbial taxa of healthy cohorts to IBD cohorts also had heterogenous methods and results, although Pittayanon et al (2020) reported some notable differences in bacterial taxa between healthy, CD and UC cohorts, based on a review of 45 studies. Thus, overall, gut microbial dysbiosis is prevalent among FGID and IBD cohorts, but it should be noted that further studies are needed to determine distinctive gut microbial characteristics in such cohorts (Duan et al, 2019; Pittayanon et al, 2020; Wang et al, 2020; Clooney et al, 2021; Abdel-Rahman and Morgan, 2022; Kim et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

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The effects of dairy on the gut microbiome and symptoms in gastrointestinal disease cohorts: a systematic review

Ní Chonnacháin,

Feeney,

Gollogly

et al. 2024

Gut. Microb.

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Bovine dairy foods provide several essential nutrients. Fermented bovine dairy foods contain additional compounds, increasing their potential to benefit gastrointestinal health. This review explores the effects of dairy consumption on the gut microbiome and symptoms in gastrointestinal disease cohorts. Human subjects with common gastrointestinal diseases (functional gastrointestinal disorders and inflammatory bowel disease) or associated symptoms, and equivalent animal models were included. A systematic literature search was performed using PubMed, Embase and Web of Science. The search yielded 3014 studies in total, with 26 meeting inclusion criteria, including 15 human studies (1550 participants) and 11 animal studies (627 subjects). All test foods were fermented bovine dairy products, primarily fermented milk and yogurt. Six studies reported increases in gastrointestinal bacterial alpha diversity, with nine studies reporting increases in relative Lactobacillus and Bifidobacterium abundance. Six studies reported increases in beneficial short-chain fatty acids, while three reported decreases. Gastrointestinal symptoms, specifically gut comfort and defecation frequency, improved in 14 human studies. Five animal studies demonstrated reduced colonic damage and improved healing. This review shows fermented bovine dairy consumption may improve gut microbial characteristics and gastrointestinal symptoms in gastrointestinal disease cohorts. Further human intervention studies are needed, expanding test foods and capturing non-selfreported gastrointestinal measures.

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“…The change in this abundance will change the metabolites of the flora and threaten the health. 3 Studies have shown that the imbalance of intestinal flora is closely related to the occurrence and development of various diseases, such as irritable bowel syndrome, 4 acute anterior uveitis, 5 rheumatoid arthritis, 6 diabetes, 7 hypertension, 8 autism, 9 and colorectal cancer. 10 This article reviews the research on the correlation between intestinal flora and diseases in recent years, in order to provide new references and strategies for clinical treatment.…”

Section: Introductionmentioning

confidence: 99%

Research Progress of Intestinal Flora and Related Diseases

Sun,

Zhang,

Zhang

et al. 2023

Chinese medicine and natural products

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The intestinal tract is an important digestive organ and detoxification organ of the human body, and its circling structure is vividly called the “second brain” of the human body. There are hundreds of millions of bacterium in the intestinal tract. These bacteria live in mutual benefit with the body, provide energy and nutrients for the host and themselves through fermented food, participate in the metabolism of the body, and form a metabolic mode of cometabolism between the host and the symbiotic flora. In addition, intestinal flora can also help the body resist the invasion of pathogens, promote human health, and resist diseases. More and more studies have shown that when the body is subjected to exogenous or endogenous stimuli, the microbial flora in the intestinal will change, and the disturbance of intestinal flora is closely related to the occurrence and development of inflammatory bowel diseases, metabolic diseases, immune system diseases, mental system diseases, and tumors. This article reviews the research progress of the intestinal flora affecting the pathogenesis of various diseases, aiming to provide new references and ideas for the clinical treatment of diseases.

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Gut Bacterial Dysbiosis in Irritable Bowel Syndrome: a Case-Control Study and a Cross-Cohort Analysis Using Publicly Available Data Sets

Abstract: Research on the gut bacteria in irritable bowel syndrome (IBS) shows discordant results due to inconsistent study designs or small sample sizes. To overcome these issues, we analyzed microbiota of 567 IBS patients and 487 healthy people from 10 shared data sets using a unified method.

Cited by 12 publications

References 28 publications

Diet and Exercise in the Management of Polycystic Ovary Syndrome: Practical Considerations for Person-Centered Care

Diet and Exercise in the Management of Polycystic Ovary Syndrome: Practical Considerations for Person-Centered Care

The effects of dairy on the gut microbiome and symptoms in gastrointestinal disease cohorts: a systematic review

Research Progress of Intestinal Flora and Related Diseases

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