Gut biofilm forming bacteria in inflammatory bowel disease

Srivastava, Ankita; Gupta, Jaya; Kumar, Sunil; Kumar, Awanish

doi:10.1016/j.micpath.2017.09.041

Cited by 55 publications

(32 citation statements)

References 100 publications

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“…Techniques including fluorescent in situ hybridization and electron microscopic studies reported the presence of bacterial biofilms in the healthy colon of mice, humans and rats (Palestrant et al, 2004;Swidsinski et al, 2005;Bollinger et al, 2007;Macfarlane et al, 2011;Motta et al, 2015). Altered levels of biofilm associated bacteria such as Bacteroides fragilis, Enterobacteriaceae family were reported in Crohn's disease and inflammatory bowel disease (Masseret et al, 2001;Macfarlane and Dillon, 2007;DuPont and DuPont, 2011;Srivastava et al, 2017). Therefore, the mucus associated bacterial biofilm also could play a role in these disorders.…”

Section: Mucus Interactions With Microbesmentioning

confidence: 99%

The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders

Herath

Hosie

Bornstein

et al. 2020

Front. Cell. Infect. Microbiol.

158

119

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Mucus is integral to gut health and its properties may be affected in neurological disease. Mucus comprises a hydrated network of polymers including glycosylated mucin proteins. We propose that factors that influence the nervous system may also affect the volume, viscosity, porosity of mucus composition and subsequently, gastrointestinal (GI) microbial populations. The gut has its own intrinsic neuronal network, the enteric nervous system, which extends the length of the GI tract and innervates the mucosal epithelium. The ENS regulates gut function including mucus secretion and renewal. Both dysbiosis and gut dysfunction are commonly reported in several neurological disorders such as Parkinson's and Alzheimer's disease as well in patients with neurodevelopmental disorders including autism. Since some microbes use mucus as a prominent energy source, changes in mucus properties could alter, and even exacerbate, dysbiosis-related gut symptoms in neurological disorders. This review summarizes existing knowledge of the structure and function of the mucus of the GI tract and highlights areas to be addressed in future research to better understand how intestinal homeostasis is impacted in neurological disorders.

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Section: Mucus Interactions With Microbesmentioning

confidence: 99%

The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders

Herath

Hosie

Bornstein

et al. 2020

Front. Cell. Infect. Microbiol.

158

119

View full text Add to dashboard Cite

show abstract

“…For example, the induced alteration of the intestinal microbiota after antibiotic use could lead to metabolic disturbances, and therefore increase susceptibility to infections (e.g., fungal and Clostridium difficile infections) 21 . Gut dysbiosis may lead to a number of diseases, including gastrointestinal disorders, obesity, cardiovascular diseases, allergies and central nervous system-related diseases, through a series of alterations 22 - 24 . This alteration involves the disruption of the mucosal barrier, which impairs local immune responses.…”

Section: The Crosstalk Between the Microbiome And Immunitymentioning

confidence: 99%

The Gut-liver Axis in Immune Remodeling: New insight into Liver Diseases

Yang¹,

Lu²,

Zhuo³

et al. 2020

Int. J. Biol. Sci.

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The gut microbiota consists of a dynamic multispecies community of bacteria, fungi, archaea, and protozoans, playing a fundamental role in the induction, training, and function of the host immune system. The liver is anatomically and physiologically linked to the gut microbiota via enterohepatic circulation, specifically receiving intestine-derived blood through the portal vein. The gut microbiota is crucial for maintaining immune homeostasis of the gut-liver axis. A shift in gut microbiota composition can result in activation of the mucosal immune response causing homeostasis imbalance. This imbalance results in translocation of bacteria and migration of immune cells to the liver, which is related to inflammation-mediated liver injury and tumor progression. In this review, we outline the role of the gut microbiota in modulating host immunity and summarize novel findings and recent advances in immune-based therapeutics associated with the gut-liver axis. Moving forward, a deep understanding of the microbiome-immune-liver axis will provide insight into the basic mechanisms of gut microbiota dysbiosis affecting liver diseases.

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“…There is no satisfactory and safe treatment option for IBD. Therefore, the current research aims to disrupt biofilms in IBD and concentrates on improving the drug ( Srivastava et al , 2017 ).…”

Section: Gut Floramentioning

confidence: 99%

Bacterial biomechanics—From individual behaviors to biofilm and the gut flora

Ishikawa

Omori

2020

APL Bioengineering

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Bacteria inhabit a variety of locations and play important roles in the environment and health. Our understanding of bacterial biomechanics has improved markedly in the last decade and has revealed that biomechanics play a significant role in microbial biology. The obtained knowledge has enabled investigation of complex phenomena, such as biofilm formation and the dynamics of the gut flora. A bottom-up strategy, i.e., from the cellular to the macroscale, facilitates understanding of macroscopic bacterial phenomena. In this Review, we first cover the biomechanics of individual bacteria in the bulk liquid and on surfaces as the base of complex phenomena. The collective behaviors of bacteria in simple environments are next introduced. We then introduce recent advances in biofilm biomechanics, in which adhesion force and the flow environment play crucial roles. We also review transport phenomena in the intestine and the dynamics of the gut flora, focusing on that in zebrafish. Finally, we provide an overview of the future prospects for the field.

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Gut biofilm forming bacteria in inflammatory bowel disease

Cited by 55 publications

References 100 publications

The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders

The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders

The Gut-liver Axis in Immune Remodeling: New insight into Liver Diseases

Bacterial biomechanics—From individual behaviors to biofilm and the gut flora

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