Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids

Liu, Chang; Du, Meng-Xuan; Xie, Li-Sheng; Wang, Wen-Zhao; Chen, Bao-Song; Yun, Chu-Yu; Sun, Xin-Wei; Luo, Xi; Jiang, Yu; Wang, Kai; Jiang, Min-Zhi; Qiao, Shan-Shan; Sun, Min; Cui, Bao-Juan; Huang, Hao-Jie; Qu, Shu-Ping; Li, Chang-Kun; Wu, Dalei; Wang, Lu-Shan; Jiang, Changtao; Liu, Hong-Wei; Liu, Shuang-Jiang

doi:10.1038/s41564-023-01570-0

Nat Microbiol

2024

DOI: 10.1038/s41564-023-01570-0

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Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids

Chang Liu,

Meng-Xuan Du,

Li-Sheng Xie

et al.

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Cited by 24 publications

References 67 publications

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The rheumatoid arthritis gut microbial biobank reveals core microbial species that associate and effect on host inflammation and autoimmune responses

Huang,

Liu,

Sun

et al. 2024

iMeta

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Gut microbiota dysbiosis has been implicated in rheumatoid arthritis (RA) and influences disease progression. Although molecular and culture‐independent studies revealed RA patients harbored a core microbiome and had characteristic bacterial species, the lack of cultured bacterial strains had limited investigations on their functions. This study aimed to establish an RA‐originated gut microbial biobank (RAGMB) that covers and further to correlates and validates core microbial species on clinically used and diagnostic inflammation and immune indices. We obtained 3200 bacterial isolates from fecal samples of 20 RA patients with seven improved and 11 traditional bacterial cultivation methods. These isolates were phylogenetically identified and selected for RAGMB. The RAGMB harbored 601 bacterial strains that represented 280 species (including 43 novel species) of seven bacterial phyla. The RAGMB covered 93.2% at species level of medium‐ and high‐abundant (relative abundances ≥0.2%) RA gut microbes, and included four rare species of the phylum Synergistota. The RA core gut microbiome was defined and composed of 20 bacterial species. Among these, Mediterraneibacter tenuis and Eubacterium rectale were two species that statistically and significantly correlated with clinically used diagnostic indices such as erythrocyte sedimentation rate (ESR) and IL‐10. Thus, M. tenuis and E. rectale were selected for experimental validation using DSS‐treated and not DSS‐treated mice model. Results demonstrated both M. tenuis and E. rectale exacerbated host inflammatory responses, including shortened colon length and increased spleen weight, decreased IL‐10 and increased IL‐17A levels in plasma. Overall, we established the RAGMB, defined the RA core microbiome, correlated and demonstrated core microbial species effected on host inflammatory and immune responses. This work provides diverse gut microbial resources for future studies on RA etiology and potential new targets for new biomedical practices.

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The rheumatoid arthritis gut microbial biobank reveals core microbial species that associate and effect on host inflammation and autoimmune responses

Huang,

Liu,

Sun

et al. 2024

iMeta

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Novel microbial modifications of bile acids and their functional implications

Zheng,

Zhang,

Zheng

et al. 2024

iMeta

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iMeta Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health

Wang,

Hou,

Luo

et al. 2024

iMeta

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The iMeta Conference 2024, held from October 11 to 13, 2024, at the Nanshan District People's Hospital in Shenzhen, China, attracted over 400 leading scientists, researchers, and industry professionals from around the world (File S1). Organized by the editorial team of iMeta, a top-tier interdisciplinary journal in biotechnology, microbiome, and bioinformatics, this conference has been emerging as a premier platform for cutting-edge research in these fields. The iMeta journal, led by Chief Editors Prof. Shuangjiang Liu and Prof. Jingyuan Fu, has an impressive impact factor of 23.8, within the top 0.5% of journals worldwide (107 out of 21,848), and 11th in mainland China. Additionally, iMetaOmics, a subjournal co-edited by Prof. Fangqing Zhao and Prof. Jun Yu, is projected to have an impact factor of over 10, positioning it as a high-level interdisciplinary journal that welcomes submissions [1].Since its inception in 2022, the iMeta journal has launched a series of conferences aimed at advancing research, fostering international collaboration, and promoting the development of the field [2]. Following successful events in Qingdao and Beijing [3], the 2024 edition marks the third event in this series that was

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Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids

Cited by 24 publications

References 67 publications

The rheumatoid arthritis gut microbial biobank reveals core microbial species that associate and effect on host inflammation and autoimmune responses

The rheumatoid arthritis gut microbial biobank reveals core microbial species that associate and effect on host inflammation and autoimmune responses

Novel microbial modifications of bile acids and their functional implications

iMeta Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health

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