2024
DOI: 10.1186/s13054-024-05006-x
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Gut-derived immune cells and the gut-lung axis in ARDS

Mairi Ziaka,
Aristomenis Exadaktylos

Abstract: The gut serves as a vital immunological organ orchestrating immune responses and influencing distant mucosal sites, notably the respiratory mucosa. It is increasingly recognized as a central driver of critical illnesses, with intestinal hyperpermeability facilitating bacterial translocation, systemic inflammation, and organ damage. The “gut-lung” axis emerges as a pivotal pathway, where gut-derived injurious factors trigger acute lung injury (ALI) through the systemic circulation. Direct and indirect effects o… Show more

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Cited by 3 publications
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