Gut dysbiosis-derived β-glucuronidase promotes the development of endometriosis

Wei, Yajing; Tan, Hao; Yang, Ruyu; Yang, Fan; Liu, Duo; Huang, Bei; Ouyang, Luo; Lei, Shijun; Wang, Zehai; Jiang, Shun-Yuan; Cai, H.; Xie, Xiaofei; Yao, Shuzhong; Liang, Y. Daniel

doi:10.1016/j.fertnstert.2023.03.032

Cited by 20 publications

(13 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the liver, estrogen combines with its metabolites resulting in conjugated estrogen, which is then metabolized into water-soluble molecules that are excreted in the urine and feces. Gut flora imbalance produces beta-glucuronidase, which prevents the combination of estrogen and glucuronic acid to reduce the inactivation of estrogen and to increase the level of circulating estrogen through the enterohepatic circulation thereby significantly stimulating the growth of ectopic lesions and participating in the pathological process of periodic bleeding of endometriosis ( Plottel and Blaser, 2011 ; Flores et al, 2012 ; Shen et al, 2012 ; Baker et al, 2017 ; Wei et al, 2023 ). Previous studies have reported that Clostridia and Ruminococcacaeae spp.…”

Section: The Possible Mechanism Of Gut Microbiota Involved In the End...mentioning

confidence: 99%

Role of the gut microbiota in the pathogenesis of endometriosis: a review

Guo,

Zhang

2024

Front. Microbiol.

View full text Add to dashboard Cite

Endometriosis is classically defined as a chronic inflammatory heterogeneous disorder occurring in any part of the body, characterized by estrogen-driven periodic bleeding, proliferation, and fibrosis of ectopic endometrial glands and stroma outside the uterus. Endometriosis can take overwhelmingly serious damage to the structure and function of multi-organ, even impair whole-body systems, resulting in severe dysmenorrhea, chronic pelvic pain, infertility, fatigue and depression in 5–10% women of reproductive age. Precisely because of a huge deficiency of cognition about underlying etiology and complex pathogenesis of the debilitating disease, early diagnosis and treatment modalities with relatively minor side effects become bottlenecks in endometriosis. Thus, endometriosis warrants deeper exploration and expanded investigation in pathogenesis. The gut microbiota plays a significant role in chronic diseases in humans by acting as an important participant and regulator in the metabolism and immunity of the body. Increasingly, studies have shown that the gut microbiota is closely related to inflammation, estrogen metabolism, and immunity resulting in the development and progression of endometriosis. In this review, we discuss the diverse mechanisms of endometriosis closely related to the gut microbiota in order to provide new approaches for deeper exploration and expanded investigation for endometriosis on prevention, early diagnosis and treatment.

show abstract

Section: The Possible Mechanism Of Gut Microbiota Involved In the End...mentioning

confidence: 99%

Role of the gut microbiota in the pathogenesis of endometriosis: a review

Guo,

Zhang

2024

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Escherichia coliderived endotoxin-induced macrophage-and TLR4-mediated higher pro-inflammatory reactions in the pelvis of women with endometriosis (Khan et al, 2010). Gut dysbiosis may lead to abnormal b-glucuronidase secretion, promoting M0 to M2 polarization affecting endometrial stromal cell proliferation, invasion, and migration, as well as induced macrophage infiltration and development of endometriotic lesions in the EMs mouse model (Wei et al, 2023).…”

Section: Macrophagesmentioning

confidence: 99%

Unraveling the microbial puzzle: exploring the intricate role of gut microbiota in endometriosis pathogenesis

Tang,

Deng,

et al. 2024

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Endometriosis (EMs) is a prevalent gynecological disorder characterized by the growth of uterine tissue outside the uterine cavity, causing debilitating symptoms and infertility. Despite its prevalence, the exact mechanisms behind EMs development remain incompletely understood. This article presents a comprehensive overview of the relationship between gut microbiota imbalance and EMs pathogenesis. Recent research indicates that gut microbiota plays a pivotal role in various aspects of EMs, including immune regulation, generation of inflammatory factors, angiopoietin release, hormonal regulation, and endotoxin production. Dysbiosis of gut microbiota can disrupt immune responses, leading to inflammation and impaired immune clearance of endometrial fragments, resulting in the development of endometriotic lesions. The dysregulated microbiota can contribute to the release of lipopolysaccharide (LPS), triggering chronic inflammation and promoting ectopic endometrial adhesion, invasion, and angiogenesis. Furthermore, gut microbiota involvement in estrogen metabolism affects estrogen levels, which are directly related to EMs development. The review also highlights the potential of gut microbiota as a diagnostic tool and therapeutic target for EMs. Interventions such as fecal microbiota transplantation (FMT) and the use of gut microbiota preparations have demonstrated promising effects in reducing EMs symptoms. Despite the progress made, further research is needed to unravel the intricate interactions between gut microbiota and EMs, paving the way for more effective prevention and treatment strategies for this challenging condition.

show abstract

“…The enhanced levels of β-glucuronidase expression observed in endometriosis lesions compared to the normal endometrium promote endometriosis progression by stimulating the proliferation and migration of endometrial stromal cells. This effect is mediated both directly and indirectly through macrophage M0 to M2 polarization, leading to an immune imbalance in vitro model from human samples and in mice models [ 175 ].…”

Section: Microbiota In Endometriosismentioning

confidence: 99%

Microbiota in Irritable Bowel Syndrome and Endometriosis: Birds of a Feather Flock Together—A Review

Salmeri,

Sinagra,

Dolci

et al. 2023

Microorganisms

View full text Add to dashboard Cite

Endometriosis and irritable bowel syndrome (IBS) are chronic conditions affecting up to 10% of the global population, imposing significant burdens on healthcare systems and patient quality of life. Interestingly, around 20% of endometriosis patients also present with symptoms indicative of IBS. The pathogenesis of both these multifactorial conditions remains to be fully elucidated, but connections to gut microbiota are becoming more apparent. Emerging research underscores significant differences in the gut microbiota composition between healthy individuals and those suffering from either endometriosis or IBS. Intestinal dysbiosis appears pivotal in both conditions, exerting an influence via similar mechanisms. It impacts intestinal permeability, triggers inflammatory reactions, and initiates immune responses. Furthermore, it is entwined in a bidirectional relationship with the brain, as part of the gut–brain axis, whereby dysbiosis influences and is influenced by mental health and pain perception. Recent years have witnessed the development of microbiota-focused therapies, such as low FODMAP diets, prebiotics, probiotics, antibiotics, and fecal microbiota transplantation, designed to tackle dysbiosis and relieve symptoms. While promising, these treatments present inconsistent data, highlighting the need for further research. This review explores the evidence of gut dysbiosis in IBS and endometriosis, underscoring the similar role of microbiota in both conditions. A deeper understanding of this common mechanism may enable enhanced diagnostics and therapeutic advancements.

show abstract

Gut dysbiosis-derived β-glucuronidase promotes the development of endometriosis

Cited by 20 publications

References 47 publications

Role of the gut microbiota in the pathogenesis of endometriosis: a review

Role of the gut microbiota in the pathogenesis of endometriosis: a review

Unraveling the microbial puzzle: exploring the intricate role of gut microbiota in endometriosis pathogenesis

Microbiota in Irritable Bowel Syndrome and Endometriosis: Birds of a Feather Flock Together—A Review

Contact Info

Product

Resources

About