Gut dysbiosis develops before metabolic disturbance and cognitive decline in high-fat diet–induced obese condition

Saiyasit, Napatsorn; Chunchai, Titikorn; Prus, Dillon; Suparan, Kanokphong; Pittayapong, Pansa; Apaijai, Nattayaporn; Pratchayasakul, Wasana; Sripetchwandee, Jirapas; D, Nipon Chattipakorn M; Chattipakorn, Siriporn C.

doi:10.1016/j.nut.2019.110576

Cited by 79 publications

(53 citation statements)

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“…Interestingly, studies in animal models demonstrated that HFD intake is related to gut dysbiosis [29,30]. Gut dysbiosis can develop as early as 2 weeks on HFD, long before the development of MtS-related symptoms [31].…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effect of a Multistrain Synbiotic Prodefen® Plus on the Systemic and Vascular Alterations Associated with Metabolic Syndrome in Rats: The Role of the Neuronal Nitric Oxide Synthase and Protein Kinase A

et al. 2020

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A high fat diet (HFD) intake is crucial for the development and progression of metabolic syndrome (MtS). Increasing evidence links gut dysbiosis with the metabolic and vascular alterations associated with MtS. Here we studied the use of a combination of various probiotic strains together with a prebiotic (synbiotic) in a commercially available Prodefen® Plus. MtS was induced by HFD (45%) in male Wistar rats. Half of the MtS animals received Prodefen® Plus for 4 weeks. At 12 weeks, we observed an increase in body weight, together with the presence of insulin resistance, liver steatosis, hypertriglyceridemia and hypertension in MtS rats. Prodefen® Plus supplementation did not affect the body weight gain but ameliorated all the MtS-related symptoms. Moreover, the hypertension induced by HFD is caused by a diminished both nitric oxide (NO) functional role and release probably due to a diminished neuronal nitric oxide synthase (nNOS) activation by protein kinase A (PKA) pathway. Prodefen® Plus supplementation for 4 weeks recovered the NO function and release and the systolic blood pressure was returned to normotensive values as a result. Overall, supplementation with Prodefen® Plus could be considered an interesting non-pharmacological approach in MtS.

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Section: Discussionmentioning

confidence: 99%

Beneficial Effect of a Multistrain Synbiotic Prodefen® Plus on the Systemic and Vascular Alterations Associated with Metabolic Syndrome in Rats: The Role of the Neuronal Nitric Oxide Synthase and Protein Kinase A

et al. 2020

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“…An increase in Enterobacteriaceae, belonging to Proteobacteria phylum, was shown to be correlated with cognitive impairment in several studies [ 13 , 15 , 17 ]. Several animal models, including diet-induced obesity (DIO) and transgenic AD model, demonstrated a link between gut dysbiosis and cognitive impairment [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. Most of the studies reported that a high-fat diet (HFD) consumption could alter the composition of gut microbiota and lead to further pathophysiological processes in cognitive impairment in HFD-fed animals [ 18 , 19 , 20 , 21 ].…”

Section: Cognitive Correlates Of Gut Dysbiosismentioning

confidence: 99%

“…Several animal models, including diet-induced obesity (DIO) and transgenic AD model, demonstrated a link between gut dysbiosis and cognitive impairment [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. Most of the studies reported that a high-fat diet (HFD) consumption could alter the composition of gut microbiota and lead to further pathophysiological processes in cognitive impairment in HFD-fed animals [ 18 , 19 , 20 , 21 ]. The lean mice with normal cognitive function receiving gut microbiota from HFD-fed mice developed cognitive impairment and the reduction in the abundance of Akkermansia muciniphila, increased of Bilophila sp., and alteration in the composition of Clostridiales [ 18 ].…”

Section: Cognitive Correlates Of Gut Dysbiosismentioning

confidence: 99%

“…A recent study from Saiyasit and colleagues revealed that gut dysbiosis, as indicated by the increased Enterobacteriaceae/Eubacteria ratio, occurred after treating the rats with HFD for two weeks, and resulted in an increased F/B ratio after eight weeks of HFD treatment. Then, HFD-fed rats developed cognitive impairment and brain pathology after 12 weeks of HFD consumption [ 20 ]. Deshpande and colleagues also observed an increase in Firmicutes and decreased Bacteroidetes after treated Male Sprague-Dawley rats with HFD; however, the cognitive performance of the treated rats was not different from that characterizing the control group [ 21 ].…”

Section: Cognitive Correlates Of Gut Dysbiosismentioning

confidence: 99%

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Cognitive-Behavioural Correlates of Dysbiosis: A Review

Luca

Chattipakorn

Sriwichaiin

et al. 2020

IJMS

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Evidence suggests an association between an altered gut microbiota (dysbiosis), cognitive performance and behaviour. This paper provides an overview of the current literature regarding the cognitive-behavioural correlates of dysbiosis, with special attention on the clinical and biochemical mechanisms underlying the association between dysbiosis, cognition (mild cognitive impairment and dementia) and behaviour (depression, schizophrenia, addiction). After providing an overview of the evidence, the review discusses the molecular aspects that could account for the cognitive-behavioural correlates of dysbiosis. Shedding light on this topic could provide insights regarding the pathogenesis of these burdening neuropsychiatric disorders and even suggest future therapeutic strategies.

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“…Gut microbes play key roles in health and disease by regulating metabolism (12), pain (13), the pathophysiology of MS (14), and onset/progression of neurodegenerative (15) and neuropsychiatric disorders (16). Although mechanisms underlying gut−brain axis communication are still poorly understood, it is now well accepted that the gut microbiome impacts many aspects of CNS development and function, including neuroimmune cell maturation, formation of the blood−brain barrier, neurogenesis, and myelination (17 (11).…”

mentioning

confidence: 99%