Gut Enterobacteriaceae and uraemic toxins - Perpetrators for ageing

Boopathi, Seenivasan; Priya, P. Snega; Haridevamuthu, B.; Nayak, S P Ramya Ranjan; Laura, Chulenbayeva; Kushugulova, Аlmagul; Arockiaraj, Jesu

doi:10.1016/j.exger.2023.112088

Cited by 22 publications

(5 citation statements)

References 94 publications

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“…[49] Interestingly, we have also found the low abundance of Enterobacteriaceae and Tannerellaceae families in the gut microbiome of our few study subjects of both the groups, which have been known to be increased during ageing and promote the occurrence of inflammation. [50,51] But the higher coverage of other preoccupied healthy gut microbiome could improve the immune cell functions by reducing Enterobacteriaceae and Tannerellaceae mediated inflammations. For example, Akkermansiaceae is associated with a healthier metabolic status and better clinical outcomes including facilitating the growth of butyrate producers, prevention of cellular senescence, reducing inflammation and the risk of cardiometabolic disease in humans with overweight or obesity.…”

Section: Discussionmentioning

confidence: 99%

Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome

Azhar,

Verma,

Robeson

et al. 2024

Molecular Nutrition Food Res

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Scope: Dietary proteins and essential amino acids (EAAs) are the major nutritional supplements that support the growth and activity of gut microbes contributing to the wellbeing of their host. This study hypothesizes that daily supplementation of the diet with either EAAs or whey protein for 12 weeks would improve the gut microbiome of older adults.Methods and results: The stool samples are processed and subjected to Illumina‐based 16S ribosomal ribonucleic acid (rRNA) gene amplicon sequencing. In both groups, the most abundant families are found in order of relative abundance included: Bacteroidaceae, Lachnospiraceae, Ruminococcaceae, Prevotellaceae, Rikenellaceae, Enterobacteriaceae, Oscillospiraceae, Tannerellaceae, and Akkermansiaceae, which indicate that these subjects are able to maintain a same healthy microbial diversity in their guts. A significant finding is a reduction of proinflammatory cytokine, interleukin‐18 (IL‐18) in the EAAs group. It also uses the standard 6‐min walking test (6MWT) as a measure of cardiopulmonary fitness. At the end of the study, the subjects in the EAAs group perform significantly better in the 6MWT as compared to the whey group.Conclusion: It seems plausible that the improved physical performance and reduced proinflammatory cytokine, IL‐18 seen in the EAAs group, are independent of changes in gut microbiota.

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Section: Discussionmentioning

confidence: 99%

Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome

Azhar,

Verma,

Robeson

et al. 2024

Molecular Nutrition Food Res

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show abstract

“…Aging [73][74][75][76] Microbiome status affects disease burden, sleep quality, Copyright© Rodney R Dietert about probiotic foods and the origins of chloroplasts to robust, vetted concepts of 2023 concerning microbes as fully cognitive beings that are supreme information gatherers making full use of quantum-based tools as they navigate the extremes of Earth and as well as our own body.…”

Section: Control Of Offspring Maladies [52-54]mentioning

confidence: 99%

The Embodied Microbiome

Dietert

2023

AJBSR

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Microbes are the most prevalent and widely distributed life form on planet Earth. They are also cognitive organisms with memory and superior problem-solving skills that use quantum phase transitions during their remarkably effective gathering and dissemination of information. This narrative review explores the biological ramifications of human holobionts physically embodying the human microbiome and connecting to the Internet of Microbes (IOM) beyond our body. Within the narrative review, we consider:the ways in which our microbial co-partners exerted control over our ancestors and continue to influence our current human generation. 2)how they mold virtually every key aspect of our life and even remain with our body in death 3) how inward-looking contemplative tools such as meditation and embodied cognition provide an ideal opportunity to connect to the vast microbial network and tap the full range of human holobiont capabilities.

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“…On Enterobacteria, its particle size distribution was detected mainly ≥ 7.1 µm near the enclosures of sheep rearing and the particle size distribution of Enterobacteria was detected mainly between 2.1 and 4.7 µm near the enclosures of cattle and pigs, while the particle size distribution of chicken was relatively small, mainly concentrated in 0.65 to 1.1 µm, accounting for approximately 78%, requiring close attention to risk prevention and control measures to avert infection. It has been found that Enterobacteria can accelerate cellular senescence, activate in ammation in vivo, and damage mitochondria thereby accelerating the aging process 34 .…”

Section: Particle Size Distribution Of Airborne Bacteria Fungi and En...mentioning

confidence: 99%

“…Total bacteria and fungi were collected using the Nutrient medium and Sabouraud medium, respectively, and incubated at 36 ± 1°C for 24-48 h and 20°C for 48-72 h 70,71 . In addition to total bacteria and fungi, more focus was on Enterobacteria, which increase with age and are consistently observed in patients with metabolic diseases 34 . Enterobacteria were collected using the McConkey medium and incubated at 36 ± 1°C for 24-48 h 68,72 .…”

Section: Bioaerosols Collectedmentioning

confidence: 99%

Distribution characteristics and potential risks of bioaerosols during scattered farming

Han

Liu

et al. 2023

Preprint

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In most economically underdeveloped areas, scattered farming and cohabitation of humans and livestock are still common. However, the production and harm of bioaerosol in these areas have not received considerable attention. In this study, bioaerosol characteristics were analyzed in scattered farming in rural areas of Northwest China. The results showed that the highest concentrations of bacteria, fungi, and Enterobacteria were 125609 ± 467 CFU/m³, 25175 ± 10305 CFU/m³, and 4167 ± 592 CFU/m³, respectively; most of the bioaerosols had particle sizes larger than 3.3 µm. 71 bacterial genera and 16 fungal genera of the potential pathogen were identified, and some zoonotic potential pathogenic genera such as Bacillus, Campylobacter, Alternaria, Aspergillus, and Penicillium were found among them. The potential exposure risk was estimated using the average daily dose rate assessment method. While the risk values are higher for adults, the potential exposure risks may be higher for left-behind children and the elderly. Moreover, our findings showed that the scattered farming pattern of human-animal coexistence can affect the indoor air environment in the surrounding area, leading to chronic respiratory diseases in the occupants. Therefore, the corresponding government departments and farmers should enhance their awareness of bioaerosol risks to reduce the incidence of infection.

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Gut Enterobacteriaceae and uraemic toxins - Perpetrators for ageing

Cited by 22 publications

References 94 publications

Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome

Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome

The Embodied Microbiome

Distribution characteristics and potential risks of bioaerosols during scattered farming

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