Gut eradication of VIM-1 producing ST9 Klebsiella oxytoca after fecal microbiota transplantation for diarrhea caused by a Clostridium difficile hypervirulent R027 strain

García‐Fernández, Sergio; Morosini, Marı́a-Isabel; Cobo, M.; Foruny, José Ramón; López-Sanromán, Antonio; Cobo, Javier; Romero, J. Zamora; Campo, Rosa del

doi:10.1016/j.diagmicrobio.2016.09.004

Cited by 26 publications

(11 citation statements)

References 14 publications

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“…Therefore, one might question the efficacy of fecal transplantation in patients with a normal microbiota diversity. The disturbed microbiota and its recovery after FMT might explain the positive results of MDR eradication in patients with recurrent CDI [8, 9]. It is interesting to note that a recent paper showed that infusion of fecal microbiota in patients with recurrent CDI decreased the number and diversity of antimicrobial resistance genes, particularly by restoring dysbiosis and reducing the number of Proteobacteria [10].…”

Section: Discussionmentioning

confidence: 99%

Fecal Microbiota Transfer for Multidrug-Resistant Gram-Negatives: A Clinical Success Combined With Microbiological Failure

Stalenhoef¹,

Terveer

Knetsch

et al. 2017

Open Forum Infectious Diseases

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Section: Discussionmentioning

confidence: 99%

Fecal Microbiota Transfer for Multidrug-Resistant Gram-Negatives: A Clinical Success Combined With Microbiological Failure

Stalenhoef¹,

Terveer

Knetsch

et al. 2017

Open Forum Infectious Diseases

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“…88 In another case involving KPC colonization, an elderly patient with recurrent CDI was found to have eradication of VIM-1 producing Klebsiella oxytoca . 89 …”

Section: Introductionmentioning

confidence: 99%

The Use of Microbiome Restoration Therapeutics to Eliminate Intestinal Colonization With Multidrug-Resistant Organisms

Gopalsamy

Woodworth

Wang

et al. 2018

The American Journal of the Medical Sciences

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Antibiotic resistance (AR) has been identified by the World Health Organization as an “increasingly serious threat to global public health.” Many mechanisms of AR have become widespread due to global selective pressures as widespread antibiotic use and/or chemotherapy. The intestine has become the primary reservoir for many resulting multidrug resistant organisms (MDROs), leading to the intestinal microbiome being dubbed the “resistome.” Intestinal decolonization has been explored as a strategy to eradicate MDROs with selective digestive tract decontamination and probiotics being notable examples with mixed results. This review focuses on fecal microbiota transplantation (FMT) and the early evidence suggesting its efficacy in decolonizing MDROs and potential mechanisms of action to reduce AR genes. Current evidence suggests FMT may have promise in restoring healthy microbial diversity and reducing AR, and clinical trials are underway to better characterize its safety and efficacy.

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“…Faecal microbiota transplant success in the context of C. difficile has led to the reporting of many small case studies assessing the efficacy of FMT for decolonization of other ARB. To date, 18 studies with a total of 101 patients have been published that use FMT to decolonize some of the most concerning ARB (Freedman, 2014;Jang et al, 2014;Singh et al, 2014;Lagier et al, 2015;Lombardo, 2015;Nancy et al, 2015;Stripling et al, 2015;Wei et al, 2015;Bili nski et al, 2016;Dubberke et al, 2016;Garc ıa-Fern andez et al, 2016;Jouhten et al, 2016;Millan et al, 2016;Smith, 2016;Sohn et al, 2016;Bilinski et al, 2017;Davido et al, 2017;Ponte et al, 2017). A pooled analysis of these data shows that 82% of patients were found to be decolonized or have a significantly reduced ARB load after FMT (Table 1).…”

Section: Microbiome Restoration Inhibits Arb Growth and Transmissionmentioning

confidence: 99%

Microbial approaches for targeting antibiotic‐resistant bacteria

Wong

Santiago

2017

Microbial Biotechnology

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SummaryAntibiotic resistant bacterial infections are a global public health challenge that has been increasing in severity and scope for the last few decades. Without creative solutions to this problem, treatment of injuries and infections will become progressively more challenging. A better understanding of the human microbiome has led to a new appreciation for the role commensal microbes play in protecting us from pathogens, especially in the gut. Antibiotics lead to disruption of the gut microbial ecosystem, enabling colonization by antibiotic resistant bacterial pathogens. Many different lines of research have identified specific bacterial taxa and mechanisms that play a role in colonization resistance, and these lines of research may one day lead to microbial therapeutics targeting antibiotic resistant bacteria. Here, we discuss a few of these strategies and the challenges they will need to overcome in order to become an effective therapeutic.

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Gut eradication of VIM-1 producing ST9 Klebsiella oxytoca after fecal microbiota transplantation for diarrhea caused by a Clostridium difficile hypervirulent R027 strain

Cited by 26 publications

References 14 publications

Fecal Microbiota Transfer for Multidrug-Resistant Gram-Negatives: A Clinical Success Combined With Microbiological Failure

Fecal Microbiota Transfer for Multidrug-Resistant Gram-Negatives: A Clinical Success Combined With Microbiological Failure

The Use of Microbiome Restoration Therapeutics to Eliminate Intestinal Colonization With Multidrug-Resistant Organisms

Microbial approaches for targeting antibiotic‐resistant bacteria

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