Gut Escherichia coli expressing Pb2+-adsorption protein reduces lead accumulation in grass carp, Ctenopharyngodon idellus

Chen, Xiao; Yang, Jinfeng; Ling, Zhenmin; Zhou, Tuoyu; Zhou, Bojian; Wang, Haoyang; Li, Xiangkai; Liu, Pu

doi:10.1016/j.envpol.2021.116634

Cited by 10 publications

(2 citation statements)

References 42 publications

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“…The liver and small intestine tissues of mice were fixed in 4% paraformaldehyde and embedded in paraffin. Subsequently, sections of the liver and small intestine tissues were stained with hematoxylin and eosin 104 and Alcian blue and periodic acid–Schiff base 105 , respectively.…”

Section: Methodsmentioning

confidence: 99%

Human supplementation with Pediococcus acidilactici GR-1 decreases heavy metals levels through modifying the gut microbiota and metabolome

Feng

Yang

Zhao

et al. 2022

npj Biofilms Microbiomes

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Exposure to heavy metals (HMs) is a threat to human health. Although probiotics can detoxify HMs in animals, their effectiveness and mechanism of action in humans have not been studied well. Therefore, we conducted this randomized, double-blind, controlled trial on 152 occupational workers from the metal industry, an at-risk human population, to explore the effectiveness of probiotic yogurt in reducing HM levels. Participants were randomly assigned to two groups: one consumed probiotic yogurt containing the HM-resistant strain Pediococcus acidilactici GR-1 and the other consumed conventional yogurt for 12 weeks. Analysis of metal contents in the blood revealed that the consumption of probiotic yogurt resulted in a higher and faster decrease in copper (34.45%) and nickel (38.34%) levels in the blood than the consumption of conventional yogurt (16.41% and 27.57%, respectively). Metagenomic and metabolomic studies identified a close correlation between gut microbiota (GM) and host metabolism. Significantly enriched members of Blautia and Bifidobacterium correlated positively with the antioxidant capacities of GM and host. Further murine experiments confirmed the essential role of GM and protective effect of GR-1 on the antioxidative role of the intestine against copper. Thus, the use of probiotic yogurt may be an effective and affordable approach for combating toxic metal exposure through the protection of indigenous GM in humans.ClinicalTrials.gov identifier: ChiCTR2100053222

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Section: Methodsmentioning

confidence: 99%

Human supplementation with Pediococcus acidilactici GR-1 decreases heavy metals levels through modifying the gut microbiota and metabolome

Feng

Yang

Zhao

et al. 2022

npj Biofilms Microbiomes

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“…Probiotics help prevent septicemia (blood poisoning) by Aeromonas in grass carp [1022]. A recombinant strain of Escherichia coli, engineered for increased lead adsorption, used as a probiotic food additive in grass carp decreased Pb accumulation in the tissues of Pb-exposed fish [1023].…”

Section: Intestinal Microbiomementioning

confidence: 99%

A Review of Grass Carp and Related Species Literature on Diet, Behavior, Toxicology, and Physiology Focused on Informing Development of Controls for Invasive Grass Carp Populations in North America

Wildhaber,

West,

Ditter

et al. 2023

Fishes

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Grass carp (Ctenopharyngodon idella) are globally important in aquaculture and aquatic vegetation control. However, escaped grass carp have established invasive populations. A targeted keyword search was performed on a carp (order: Cypriniformes) literature database maintained by the U.S. Geological Survey to identify literature relevant to grass carp. Additional sources cited in reviewed documents and provided by numerous reviewers were also included. There were three focus areas designed to provide support for invasive grass carp management: (1) diet and behavior; (2) physiological constraints, toxicity, and biology; and (3) gut physiology. Each focus area provides information to guide development of potential pathways for invasive grass carp control. Information from other carp species was used to fill in gaps where grass carp information was lacking and provide additional, potential research directions. Diet-related information included food selection and aquacultural diet formulations. Behavioral information included stimuli and non-physical barriers to attract, repel, or stop movement. Physiological constraints, toxicology, reproductive control, and biological control provide a research review for control options. Gut physiology and related control pathways provide knowledge to improve toxin or pathogen delivery. This review provides a basis for developing approaches and research for controlling invasive grass carp populations, aquaculture, and native population management.

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Designed bacteria based on natural pbr operons for detecting and detoxifying environmental lead: A mini-review

Hui,

Ma,

Wang

et al. 2023

Ecotoxicology and Environmental Safety

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Gut Escherichia coli expressing Pb2+-adsorption protein reduces lead accumulation in grass carp, Ctenopharyngodon idellus

Cited by 10 publications

References 42 publications

Human supplementation with Pediococcus acidilactici GR-1 decreases heavy metals levels through modifying the gut microbiota and metabolome

Human supplementation with Pediococcus acidilactici GR-1 decreases heavy metals levels through modifying the gut microbiota and metabolome

A Review of Grass Carp and Related Species Literature on Diet, Behavior, Toxicology, and Physiology Focused on Informing Development of Controls for Invasive Grass Carp Populations in North America

Designed bacteria based on natural pbr operons for detecting and detoxifying environmental lead: A mini-review

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