Gut hormones, adipokines, and pro- and anti-inflammatory cytokines/markers in loss of control eating: A scoping review

Yu, Yang; Fernandez, I. Diana; Meng, Ying; Zhao, Wenjuan; Groth, Susan W.

doi:10.1016/j.appet.2021.105442

Cited by 22 publications

(17 citation statements)

References 138 publications

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“…To date, there is a scarcity of studies on neuroendocrinological alterations in BED as well as in other forms of overeating such as grazing. However, in populations suffering from loss of control eating, which is also a characteristic of BED, dysregulated peptide hormone functioning has been reported, including lower levels of fasting ghrelin and higher levels of leptin, dysregulated post-meal ghrelin concentrations as well as alterations regarding CCK, and peptide YY 60 . Such alterations could suggest a resistance to satiety signalling in individuals suffering from binge eating that can be a risk factor to trigger uncontrolled food intake.…”

Section: [H2] Food Intake Regulation Pathwaysmentioning

confidence: 99%

Binge eating disorder

Giel¹,

Bulik

Fernández‐Aranda

et al. 2022

Nat Rev Dis Primers

132

101

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Primer articlesNature Reviews publishes timely, authoritative articles that are of broad interest and exceptional quality. Thank you for taking the time to help us to ensure that our articles meet these high standards.Primer articles in Nature Reviews provide an overview of a disease or disorder. Primers are intended to provide an authoritative, global perspective for the benefit of biomedical scientists, putting current clinical and translational challenges into context. These overview articles are meant to be introductory and cover all aspects from epidemiology to disease mechanisms, diagnosis and treatment.Please submit your report in narrative form and provide detailed justifications for all statements. Confidential comments to the editor are welcome, but it is helpful if the main points are stated in the comments for transmission to the authors.Please note that all Primer articles follow the same set organization of the main headings. Additionally, Nature Reviews articles will be thoroughly edited before publication and all figures will be redrawn by our in-house art editors. We therefore request that you concentrate on the scientific content of the article and display items, rather than the 'order' of the content or any minor errors in language or grammar that might be present in the draft version. Please consider and comment on the following points when reviewing this manuscript:• Is the article written for a broad audience, including biomedical scientists, translational researchers, medical students and clinicians?• Is the global perspective well represented?• Does the article present the current state of the art in the disease, without much emphasis on historical aspects?• Are the open research questions outlines and comprehensive?• Does the length of the article seem appropriate?• Are the ideas logically presented and discussed?• Does the article provide a balanced overview of the literature? Please bear in mind that it may not be possible to cover all aspects of a field within such a concise article.• Is the discussion fair and accurate? Although our authors are encouraged to be opinionated, they should not ignore alternative points of view. • Do the figures, boxes and tables provide clear and accurate information? Are there any additional or alternative display items that you think that the authors should include?• Are the references appropriate and up-to-date? Do they reflect the scope of the article?• Are you aware of any undeclared conflicts of interest that might affect the balance, or perceived balance, of the article?

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Section: [H2] Food Intake Regulation Pathwaysmentioning

confidence: 99%

Binge eating disorder

Giel¹,

Bulik

Fernández‐Aranda

et al. 2022

Nat Rev Dis Primers

132

101

View full text Add to dashboard Cite

show abstract

“…Despite its stimulating appetite role, ghrelin has been described as a hedonic neural reinforcer for natural (e.g., food) and non-natural rewards (e.g., drugs) by its interaction with dopamine signaling in the mesolimbic circuit and other neuroendocrine pathways (e.g., linked to stress, appetite, and metabolic processing) [ 12 ]. Ghrelin has been extensively studied in different addictive-related disorders, such as binge eating disorder (BED) and obesity [ 13 , 14 ], as well as in SUDs [ 15 ], especially involving alcohol [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…A single study exploring leptin concentrations in GD did not find significant differences compared with those in HCs [ 35 ]. Despite there are fewer studies related to adiponectin and addictions, decreased serum concentrations have been reported in obesity with and without eating disorders and in opioid use disorder [ 14 , 36 ]. Adiponectin has also been proposed as a biomarker of craving, like ghrelin, in alcohol use disorder [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

Are Signals Regulating Energy Homeostasis Related to Neuropsychological and Clinical Features of Gambling Disorder? A Case–Control Study

et al. 2022

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Gambling disorder (GD) is a modestly prevalent and severe condition for which neurobiology is not yet fully understood. Although alterations in signals involved in energy homeostasis have been studied in substance use disorders, they have yet to be examined in detail in GD. The aims of the present study were to compare different endocrine and neuropsychological factors between individuals with GD and healthy controls (HC) and to explore endocrine interactions with neuropsychological and clinical variables. A case–control design was performed in 297 individuals with GD and 41 individuals without (healthy controls; HCs), assessed through a semi-structured clinical interview and a psychometric battery. For the evaluation of endocrine and anthropometric variables, 38 HCs were added to the 41 HCs initially evaluated. Individuals with GD presented higher fasting plasma ghrelin (p < 0.001) and lower LEAP2 and adiponectin concentrations (p < 0.001) than HCs, after adjusting for body mass index (BMI). The GD group reported higher cognitive impairment regarding cognitive flexibility and decision-making strategies, a worse psychological state, higher impulsivity levels, and a more dysfunctional personality profile. Despite failing to find significant associations between endocrine factors and either neuropsychological or clinical aspects in the GD group, some impaired cognitive dimensions (i.e., WAIS Vocabulary test and WCST Perseverative errors) and lower LEAP2 concentrations statistically predicted GD presence. The findings from the present study suggest that distinctive neuropsychological and endocrine dysfunctions may operate in individuals with GD and predict GD presence. Further exploration of endophenotypic vulnerability pathways in GD appear warranted, especially with respect to etiological and therapeutic potentials.

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“…They potentiate insulin secretion by acting directly on β-cells in a glucose-dependent manner ( 70 ). Meanwhile, GLP-1 and CCK act on hypothalamus to inhibit food intake, which is a negative feedback mechanism for metabolic regulation ( 71 ). They also act on adipocytes.…”

Section: Gpr40 and Glucose Metabolismmentioning

confidence: 99%

Free fatty acid receptors in the endocrine regulation of glucose metabolism: Insight from gastrointestinal-pancreatic-adipose interactions

Zhao

2022

Front. Endocrinol.

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Glucose metabolism is primarily controlled by pancreatic hormones, with the coordinated assistance of the hormones from gastrointestine and adipose tissue. Studies have unfolded a sophisticated hormonal gastrointestinal-pancreatic-adipose interaction network, which essentially maintains glucose homeostasis in response to the changes in substrates and nutrients. Free fatty acids (FFAs) are the important substrates that are involved in glucose metabolism. FFAs are able to activate the G-protein coupled membrane receptors including GPR40, GPR120, GPR41 and GPR43, which are specifically expressed in pancreatic islet cells, enteroendocrine cells as well as adipocytes. The activation of FFA receptors regulates the secretion of hormones from pancreas, gastrointestine and adipose tissue to influence glucose metabolism. This review presents the effects of the FFA receptors on glucose metabolism via the hormonal gastrointestinal-pancreatic-adipose interactions and the underlying intracellular mechanisms. Furthermore, the development of therapeutic drugs targeting FFA receptors for the treatment of abnormal glucose metabolism such as type 2 diabetes mellitus is summarized.

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Gut hormones, adipokines, and pro- and anti-inflammatory cytokines/markers in loss of control eating: A scoping review

Cited by 22 publications

References 138 publications

Binge eating disorder

Binge eating disorder

Are Signals Regulating Energy Homeostasis Related to Neuropsychological and Clinical Features of Gambling Disorder? A Case–Control Study

Free fatty acid receptors in the endocrine regulation of glucose metabolism: Insight from gastrointestinal-pancreatic-adipose interactions

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