Gut hormones and reproduction

Izzi‐Engbeaya, Chioma; Dhillo, Waljit S.

doi:10.1016/j.ando.2022.06.003

Cited by 4 publications

(4 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various mediators enable interactions between the reproductive and metabolic axis including neuroendocrine hormones like kisspeptin 3,18,19 . Metabolic hormones specifically secreted by enteroendocrine cells of the gastrointestinal tract interact directly or indirectly with the reproductive axis 3,19,62 . Although recent studies have recognized their prominence, evidence for their role in reproduction is scarce.…”

Section: Gut Hormones In Infertilitymentioning

confidence: 99%

“…3,18,19 Metabolic hormones specifically secreted by enteroendocrine cells of the gastrointestinal tract interact directly or indirectly with the reproductive axis. 3,19,62 Although recent studies have recognized their prominence, evidence for their role in reproduction is scarce. Receptors of NPY, ghrelin, GLP-1 and GIP among other gut hormones are present in the hypothalamus, pituitary, adrenal glands or ovaries of women.…”

Section: Infertilitymentioning

confidence: 99%

See 1 more Smart Citation

The impact of diabetes and obesity on fertility and the potential role of gut hormones as treatment

Sridhar,

Khan,

Moffett

2023

Diabet Med

View full text Add to dashboard Cite

Obesity poses an enormous threat to life expectancy and quality of life in people with associated metabolic comorbidities. Alongside its metabolic implications, obesity and associated diabetes impair female reproductive function, causing infertility and polycystic ovarian syndrome (PCOS). Recently, gut hormones and their receptors have been identified in various reproductive organs indicating their potential regulatory effects on reproductive function. This review focuses on modifications during obesity, diabetes and related infertility with an emphasis on gut hormones and their therapeutic potential. Evidence suggests that bariatric surgery has positive effects on fertility and PCOS where major alterations in metabolism occurs through restoration of gut hormone levels. This is thought to be due to the indirect effect weight loss and regulation of blood glucose has on the hypothalamic‐pituitary‐ovarian and hypothalamic‐pituitary‐adrenal axis influencing reproduction. Further research is required to elucidate the cellular mechanisms involved in the direct effects of gut hormone receptor activation on reproductive tissues. Current observations suggest a therapeutic role for gut hormones in infertility/PCOS associated with metabolic pathophysiology.

show abstract

Section: Gut Hormones In Infertilitymentioning

confidence: 99%

Section: Infertilitymentioning

confidence: 99%

The impact of diabetes and obesity on fertility and the potential role of gut hormones as treatment

Sridhar,

Khan,

Moffett

2023

Diabet Med

View full text Add to dashboard Cite

show abstract

“…GIH can physiologically affect the secretion of sex hormones such as luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T), and affect the blood-testis barrier (BTB) to regulate spermatogenesis and can pathologically cause vascular inflammation, leading to erectile dysfunction (ED) [3,4]. In addition, gut microbiota (GM) can also regulate the release and function of GIH, and there may be an interaction between them [3,5,6].…”

Section: Introductionmentioning

confidence: 99%

Testis–Gut-Reproduction Axis: The Key to Reproductive Health

Zou,

Chen,

et al. 2024

Andrologia

View full text Add to dashboard Cite

Reproductive health is an important issue for humanity. In the context of the increasing incidence rate of male infertility, it is essential to find the factors that affect male reproductive health. Gastrointestinal health is closely related to reproductive health. Gastrointestinal hormones (GIH) and gut microbiota (GM), as important material foundations for gastrointestinal function, can promote or inhibit testicular reproductive function, including spermatogenesis, sperm maturation, androgen synthesis, and even broader male diseases such as sexual function, prostate cancer, etc. On the contrary, the functional health of the testes is also of great significance for the stability of gastrointestinal function. This review mainly discusses the important regulatory effects of GIH and GM on male reproductive function.

show abstract

“…5 Interestingly, accumulating evidence suggests that GLP-1 and its analogues may have potential implications in the regulation of reproductive function, opening new avenues for fertility treatment. 6 GLP-1 and its receptor, GLP-1R, have been identified in various reproductive tissues, including the hypothalamus, pituitary, ovary, and testis. 7 GLP-1R activation has been linked to the modulation of the hypothalamic-pituitary-gonadal (HPG) axis, which plays a pivotal role in the regulation of reproductive function.…”

Section: Introductionmentioning

confidence: 99%

GLP-1 analogue as a novel approach for fertility treatment: unravelling the therapeutic potential: A narrative review

Lindenberg DVM PhD,

Ulsø Bsc.med PhD,

Almind MD PhD

et al. 2023

OGIJ

View full text Add to dashboard Cite

Glucagon-like peptide-1 (GLP-1) analogues have emerged as promising therapeutic agents for the treatment of type 2 diabetes. Recent studies have suggested a potential role of GLP-1 in reproductive functions, offering new avenues for fertility treatment. This paper aims to review the current understanding of GLP-1 analogues to human reproduction, focusing on their potential application in fertility treatment, and discussing the molecular mechanisms and signalling pathways involved. Further, we highlight the challenges and future directions in the application of GLP-1 analogues for fertility treatment.

show abstract

Gut hormones and reproduction

Cited by 4 publications

References 45 publications

The impact of diabetes and obesity on fertility and the potential role of gut hormones as treatment

The impact of diabetes and obesity on fertility and the potential role of gut hormones as treatment

Testis–Gut-Reproduction Axis: The Key to Reproductive Health

GLP-1 analogue as a novel approach for fertility treatment: unravelling the therapeutic potential: A narrative review

Contact Info

Product

Resources

About