2014
DOI: 10.1096/fj.14-259598
|View full text |Cite
|
Sign up to set email alerts
|

Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells

Abstract: Gut microbiota alterations have been described in several diseases with altered gastrointestinal (GI) motility, and awareness is increasing regarding the role of the gut microbiome in modulating GI function. Serotonin [5-hydroxytryptamine (5-HT)] is a key regulator of GI motility and secretion. To determine the relationship among gut microbes, colonic contractility, and host serotonergic gene expression, we evaluated mice that were germ-free (GF) or humanized (HM; ex-GF colonized with human gut microbiota). 5-… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

16
801
2
11

Year Published

2015
2015
2023
2023

Publication Types

Select...
5
5

Relationship

0
10

Authors

Journals

citations
Cited by 994 publications
(830 citation statements)
references
References 46 publications
(56 reference statements)
16
801
2
11
Order By: Relevance
“…Gut microbiota act on EC also through SCFA (butyrate and acetate) and increases production of 5-HT primarily in the distal gut. 130 SCFAs are able to stimulate the enteric and sympathetic nervous system 49 and increase gut transit. 8,131 In addition, changes in microbiota can alter levels of 5-HT and other neuroactive substances such as nitric oxide and substance P and probably dysregulation of peripheral 5-HT is involved in the pathogenesis of IBS.…”
Section: Gut-brain Signaling -The Gut Brain Axismentioning
confidence: 99%
“…Gut microbiota act on EC also through SCFA (butyrate and acetate) and increases production of 5-HT primarily in the distal gut. 130 SCFAs are able to stimulate the enteric and sympathetic nervous system 49 and increase gut transit. 8,131 In addition, changes in microbiota can alter levels of 5-HT and other neuroactive substances such as nitric oxide and substance P and probably dysregulation of peripheral 5-HT is involved in the pathogenesis of IBS.…”
Section: Gut-brain Signaling -The Gut Brain Axismentioning
confidence: 99%
“…The gut microbiota from ex-GF mice colonized with human gut microbiota and conventionally raised mice the colonic rate limiting for mucosal serotonin synthesis; tryptophan hydroxylase 1 mRNAs as well as the neuroendocrine secretion gene; chromogranin A with no effect on the serotonin transporter or serotonin catabolic gene; monoamine oxidase A. 85 Interestingly, the reported effects did not result from an increase in the number of the cells producing serotonin but rather through the action of SCFAs. Changes in the levels of serotonin were also linked to the pathology of GI disorders, in which modulation of serotonin secretion is proposed as a treatment given its significant role in the enteric nervous system (ENS) and gut motility.…”
mentioning
confidence: 99%
“…15 This is not surprising since key to co-metabolism of the gut-brain is a well-known finding that the microbiota produces >40 known neurotransmitters, including an approximate estimate of 50% of the dopamine and 90% of the serotonin in the body used in neurotransmission. 16 A wide mix of extrinsic and intrinsic neuropsychotropic-modulating microbes and pathogens affect these and other gut processes. Gut microbes do promote colonic serotonin production via effecting the short-chain fatty acids on enterochromaffin cells.…”
Section: The Microbiota-gut-brainneuroendocrine Axis and Psychiatric mentioning
confidence: 99%