2022
DOI: 10.21203/rs.3.rs-2064240/v1
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Gut microbial GABAergic signaling imprints alveolar macrophages and pulmonary response to viral infection associated with psychological stress

Abstract: Background Epidemiological evidences reveal that populations with psychological stress have an increased likelihood of respiratory viral infection involving influenza A virus (IAV) and SARS-CoV-2, but the mechanism remains elusive. Results By exploiting a chronic restraint stress (CRS) mouse model, we demonstrated that psychiatric stress substantially increased hosts’ vulnerability to viral pneumonia, concurrent with deregulated alveolar macrophages (AMs) and disturbed gut microbiome. The central importance … Show more

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